AI & Estro?

[MickyBlues]

Ok I would say Ive read quite a bit on estro and AI's and how they work in general. I know AI's duty is to bind to the aromatise enzyme making it useless and preventing Test's conversion into estrogen. But let's say you already have high estrogen levels before you start taking an AI. What happens to the existing estrogen? I guess what Im asking is does the AI just basically inhibit any future conversion of test into estro? What about ridding the body of existing estro, does the AI take care of this to, if so how?

 

[AhMadKooL]

A compoud that does that is Letro

 

[MickyBlues]

A compoud that does that is Letro

Does anyone else have first hand knowledge/experience with Letro doing this?

 

[MickyBlues]

Bump. Does anyone have any first hand experience on how to rid estro already present in the body (not being on cycle!)? I know all the AI's type I(aromasin) & II(Ldex, Letro) bind to the aromataze enzyme inhibiting "future" test conversion to estrogen. But what if Estro is already present how would one get rid of it?

 

[nydj66]

I know of no way to lower estrogen immediately. You can immediately block it at some receptors by taking a SERM like nolvadex. But if you start an AI today, you're looking at more than a week before your estrogen levels will be lowered.

 

[MickyBlues]

I know of no way to lower estrogen immediately. You can immediately block it at some receptors by taking a SERM like nolvadex. But if you start an AI today, you're looking at more than a week before your estrogen levels will be lowered.

I understand this. I know AI's take at least a week before stabelizing in the blood and being effective. What about existing estro, do AI's rid estro from the body or simply just stop conversion via the aromatase enzyme? Im still not clear on this.

 

[AhMadKooL]

I understand this. I know AI's take at least a week before stabelizing in the blood and being effective. What about existing estro, do AI's rid estro from the body or simply just stop conversion via the aromatase enzyme? Im still not clear on this.

From what i know letro brings down estrogen levels to 0

 

[MickyBlues]

From what i know letro brings down estrogen levels to 0

That's what Im starting to understand about Letro. However, I also read there is a rebound effect after discontinuing. Would anyone know how much of a rebound affect? Also would you prevent if you could such a rebound of estro?

 

[nydj66]

I understand this. I know AI's take at least a week before stabelizing in the blood and being effective. What about existing estro, do AI's rid estro from the body or simply just stop conversion via the aromatase enzyme? Im still not clear on this.

AI's lower estrogen solely by interfering the aromatization of testosterone and thererby eliminating the new supply. There is nothing I know of that will take existing estrogen out of your bloodstream. Nothing except the liver (I should say).

 

[AhMadKooL]

That's what Im starting to understand about Letro. However, I also read there is a rebound effect after discontinuing. Would anyone know how much of a rebound affect? Also would you prevent if you could such a rebound of estro?

None that i know off. This is the drugs profile:
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a698004.html

It says:
"Letrozole is in a class of drugs known as aromatase inhibitors; it prevents formation of estrogen. Although estrogen is a hormone naturally produced by the body, it can stimulate and maintain the growth of certain types of cancer. Letrozole slows or stops the growth of cancer cells by decreasing the amount of estrogen produced."

 

[Ulter]

Letro should be used as a last resort. When all else fails.
You can't get rid of your estrogen, you can only cut off the supply of new estrogen as was posted.
You should use AIFM as your aromatase inhibitor.

 

[krishna]

A compoud that does that is Letro

Letro is an AI. The best way to control existing estrogen is nolvadex.

 

[AhMadKooL]

Letro is an AI. The best way to control existing estrogen is nolvadex.

Check this link:
http://www.mesomorphosis.com/steroid-profiles/nolvadex.htm

It says:
It is not correct that Nolvadex reduces levels of estrogen: rather, it blocks estrogen from estrogen receptors and, in those tissues where it is an antagonist, causes the receptor to do nothing.

As for letro:
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a698004.html
It says:
Letrozole is in a class of drugs known as aromatase inhibitors; it prevents formation of estrogen. Although estrogen is a hormone naturally produced by the body, it can stimulate and maintain the growth of certain types of cancer. Letrozole slows or stops the growth of cancer cells by decreasing the amount of estrogen produced.

So as you can see you cannot get rid of existing estrogen in the blood (The liver does that) But you can see that Letro prohibits the formation of estrogen while nolva only blocks the receptor sites; Therefore Letro is much stronger than Nolva

 

[krishna]

Check this link:
http://www.mesomorphosis.com/steroid-profiles/nolvadex.htm

It says:
It is not correct that Nolvadex reduces levels of estrogen: rather, it blocks estrogen from estrogen receptors and, in those tissues where it is an antagonist, causes the receptor to do nothing.

As for letro:
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a698004.html
It says:
Letrozole is in a class of drugs known as aromatase inhibitors; it prevents formation of estrogen. Although estrogen is a hormone naturally produced by the body, it can stimulate and maintain the growth of certain types of cancer. Letrozole slows or stops the growth of cancer cells by decreasing the amount of estrogen produced.

So as you can see you cannot get rid of existing estrogen in the blood (The liver does that) But you can see that Letro prohibits the formation of estrogen while nolva only blocks the receptor sites; Therefore Letro is much stronger than Nolva

Like I just said, which your post confirmed, letro is an AI. If you have excessively high levels of estrogen, the only way to control it (like I mentioned previously) is to take nolvadex to block the estrogen receptor. I never said that nolvadex reduces estrogen, but rather that it controls its effects. Your best bet would be to take nolva and a-dex, aromasin, or AIFM together, but you rarely need letro (unless you have severe gyno symptoms), as it is too strong.

 

[AhMadKooL]

Like I just said, which your post confirmed, letro is an AI. If you have excessively high levels of estrogen, the only way to control it (like I mentioned previously) is to take nolvadex to block the estrogen receptor. I never said that nolvadex reduces estrogen, but rather that it controls its effects. Your best bet would be to take nolva and a-dex, aromasin, or AIFM together, but you rarely need letro (unless you have severe gyno symptoms), as it is too strong.

Yep i know it's an AI

Not to flame you bro but you said in your original post that the best way to control existing estrogen is nolvadex. Which is not true first off because existing estrogen in the blood is there till the liver takes care of it and the best AI is Letro

 

[krishna]

Yep i know it's an AI

Not to flame you bro but you said in your original post that the best way to control existing estrogen is nolvadex. Which is not true first off because existing estrogen in the blood is there till the liver takes care of it and the best AI is Letro

If you have high estrogen, you want to stop it from acting on the receptors right? RIGHT? When you block the receptors, you control for negative estrogen effects. This is what I meant, and this is what I said. Don't get caught up in semantics. The existing estrogen is estrogen that is already present. You said it yourself that only the liver can take care of it, not an AI like letro; letro will do nothing for existing estrogen. In the meantime, you can control its effects with nolvadex. You pretty much unknowingly debated in favor of my post, and against your own.

 

[AhMadKooL]

If you have high estrogen, you want to stop it from acting on the receptors right? RIGHT? When you block the receptors, you control for negative estrogen effects. This is what I meant, and this is what I said. Don't get caught up in semantics. The existing estrogen is estrogen that is already present. You said it yourself that only the liver can take care of it, not an AI like letro; letro will do nothing for existing estrogen. In the meantime, you can control its effects with nolvadex. You pretty much unknowingly debated in favor of my post, and against your own.

Where in any of my post did I say it controls exisiting estrogen; I only said it brings down estrogen levels to 0 by eliminating any new production of estrogen. If you look at your original post you said:

Letro is an AI. The best way to control existing estrogen is nolvadex.

Again you see you used the words BEST & EXISTING not me

The BEST (ie the most effective) AI is Letro
The EXISTING estrogen cannot be removed from the blood except by the liver

 

[krishna]

Where in any of my post did I say it controls exisiting estrogen; I only said it brings down estrogen levels to 0 by eliminating any new production of estrogen. If you look at your original post you said:



Again you see you used the words BEST & EXISTING not me

The BEST (ie the most effective) AI is Letro
The EXISTING estrogen cannot be removed from the blood except by the liver

You are one dense mother fucker!

 

[AhMadKooL]

You are one dense mother fucker!

Fuck you bitch; if you can't handle being wrong It's not my problem biatch; learn how to accept being wrong once in while you mother fucking little piece of ass wipe shit

 

[Zuperman]

To Krishna and AhmadKool!
U r both top notch guys, I like u both and Trust u both so please stop fighting and using that kind of language ya metnakeen!!

 

[AhMadKooL]

To Krishna and AhmadKool!
U r both top notch guys, I like u both and Trust u both so please stop fighting and using that kind of language ya metnakeen!!

I know, I know; But he started it ; anyways ezyak ya Zuperman! Tahya masir!

 

[krishna]

Fuck you bitch; if you can't handle being wrong It's not my problem biatch; learn how to accept being wrong once in while you mother fucking little piece of ass wipe shit

This whole post was about existing estrogen (I mentioned existing, not you). Letro will do NOTHING for existing estrogen. You said it yourself, the liver takes care of it. I was simply pointing out that if you don't want bad effects from existing estrogen, the only way to control/prevent/stop it from happening is to use a SERM (nolva). Nolva is not an AI, and for some reason, you keep pointing out that letro is. I know it is, and I know it's the strongest one. That has nothing to do with estrogen that is already present. With nolva, you can block already present estrogen from having any effect, while the liver gets rid of it. I am not wrong, and this post is doing wonders for your character

 

[AhMadKooL]

This whole post was about existing estrogen (which I mentioned, not you). Letro will do NOTHING for existing estrogen. You said it yourself, the liver takes care of it. I was simply pointing out that if you don't want bad effects from existing estrogen, the only way to control/prevent/stop it from happening is to use a SERM (nolva). Nolva is not an AI, and for some reason, you keep pointing out that letro is. I know it is, and I know it's the strongest one. I am not wrong, and this post is doing wonders for your character

Bro: speaking of character it's you who started the childish name calling; Plus you had to bomb me instead of dealing with the fact that your wrong; Thats a bit childish don't you think

 

[krishna]

Bro: speaking of character it's you who started the childish name calling; Plus you had to bomb me instead of dealing with the fact that your wrong; Thats a bit childish don't you think

I said you were dense; it's not a name, it's an adjective. You're wrong for even bringing up letro when talking about ALREADY EXISTING ESTROGEN. I know what letro is and what it does. The point is that you're just a little off track.

 

[AhMadKooL]

I said you were dense; it's not a name, it's an adjective. You're wrong for even bringing up letro when talking about ALREADY EXISTING ESTROGEN. I know what letro is and what it does. The point is that you're just a little off track.

Yep and you added the words mother fucker; which nobody likes to be called that

 

[GymIntensity]

on a side note, i could have sworn that Mr. X has suggested Letro for "existing" gyno...just my two sense..... but far as i see it letro is to "keep" estro from forming while nolva is to make current estro go away......... LOL funny post anyways.... no need to argue bros

 

[GymIntensity]

and yes i know "sense" is spelled wrong lol.

 

[Quiltie]

You guys never mentioned Exemestane.

Exemestane 25 mg daily reduced whole body aromatization (as measured by injecting
radiolabeled androstenedione) by 98% in postmenopausal women with breast cancer. After a
single dose of exemestane 25 mg, the maximal suppression of circulating estrogens occurred 2 to
3 days after dosing and persisted for 4 to 5 days.
It's a "suicidal aromatase inhibitor", and think that it works the fastest due to the fact that it deals with the existing hormone levels- not production.
Rebound is certainly possible.

 

[Mr.X]

on a side note, i could have sworn that Mr. X has suggested Letro for "existing" gyno...

Correct for the most part. If you want help with existing estrogen in the system nolvadex would be in order - it's not going to work magic, but it will help

 

[AhMadKooL]

Correct for the most part. If you want help with existing estrogen in the system nolvadex would be in order - it's not going to work magic, but it will help

Did you mean letro Mr X or Nolva?

 

[Mr.X]

Did you mean letro Mr X or Nolva?

Letro for existing gyno, and a SERM like nolva for the estrogen issue discussed in this post.

 

[krishna]

Yep and you added the words mother fucker; which nobody likes to be called that

What if I would of said you were one cool mother fucker? I bet you wouldn't of minded it then . Look, we're both just looking at this from different perspectives. Let's squash it bro. Next time you got good k comin .

 

[Mr.X]

What if I would of said you were one cool mother fucker? I bet you wouldn't of minded it then . Look, we're both just looking at this from different perspectives. Let's squash it bro. Next time you got good k comin .

good, now kiss and make up....I would cry but my clomid is done

 

[AhMadKooL]

What if I would of said you were one cool mother fucker? I bet you wouldn't of minded it then . Look, we're both just looking at this from different perspectives. Let's squash it bro. Next time you got good k comin .

Cool beans bro

 

[Mr.X]

Cool beans bro

How nice, you guys made up