After cycle

[BodyND]

After a 50 mcg everyday T3 cycle what are ways i can make my thyroid production go back to normal help please.

 

[lookinfit75]

I don't have an answer really but just crurious, what makes you think your thyroid is shut down and how long was your T3 run? Were you doing any other stuff along with the T3?

 

[BodyND]

I don't have an answer really but just crurious, what makes you think your thyroid is shut down and how long was your T3 run? Were you doing any other stuff along with the T3?

Cycle:
Stan : 30-40 mg a day
T3 : 50-100 mcg a day
clen : 80-140 mcg a day


Day 1 – 7 = Stan = 40mg, T3 = 50mcg, Clen = 80 mcg.
Day 8 – 14 = Stan = 40mg, T3 = 50mcg, Clen = 80mcg.
Day 15 – 21 = Stan = 40 mg, T3 = 50 mg, Clen = off
Day 22 – 28 = Stan = 40 mg , T3 = 50 mcg, Clen = off
Day 29 – 35 = T3 =50mcg , Clen = 80 mcg
Day 36 -42 = T3 =50mcg, Clen = 80mcg

4 weeks stanozlol
6 weeks cytomel
2 weeks clen
Havent started cycle yet but am concerned about after the cycle i dont want my thyroid to shut down at all.

 

[BodyND]

Help .. Please

 

[needtogetaas]

After a 50 mcg everyday T3 cycle what are ways i can make my thyroid production go back to normal help please.

I have a t-3 after product coming out soon.

right now


The 3rd proven ingredient in forged post cycle is Fenugreek

During a Designer supplement cycle it is always wise to use a liver sup (more on this later) but even after a cycle it is good to help the liver recover from the stress that you just put it threw. Your liver processes everything from Protein to estrogen. Every hormone is metabolized threw the liver. So Optamel liver function is of the utmost importance when coming off cycle. Repairing and rebuilding the liver after a harsh oral cycle is always a smart choice. Fenugreek has been proven to not only protect but (ready) repair liver damage

Alcohol Alcohol. 2006 May-Jun;41(3):267-73. Epub 2006 Mar 30. Links
Fenugreek (Trigonella foenum graecum) seed extract prevents ethanol-induced toxicity and apoptosis in Chang liver cells.Kaviarasan S, Ramamurty N, Gunasekaran P, Varalakshmi E, Anuradha CV.
Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, India.

The protective effect of a polyphenolic extract of fenugreek seeds (FPEt) against ethanol (EtOH)-induced toxicity was investigated in human Chang liver cells. Cells were incubated with either 30 mM EtOH alone or together in the presence of seed extract for 24 h. Assays were performed in treated cells to evaluate the ability of seeds to prevent the toxic effects of EtOH. EtOH treatment suppressed the growth of Chang liver cells and induced cytotoxicity, oxygen radical formation and mitochondrial dysfunction. Reduced glutathione (GSH) concentration was decreased significantly (P < 0.05) while oxidized glutathione (GSSG) concentration was significantly elevated in EtOH-treated cells as compared with normal cells. Incubation of FPEt along with EtOH significantly increased cell viability in a dose-dependent manner, caused a reduction in lactate dehydrogenase leakage and normalized GSH/GSSG ratio. The extract dose-dependently reduced thiobarbituric acid reactive substances formation. Apoptosis was observed in EtOH-treated cells while FPEt reduced apoptosis by decreasing the accumulation of sub-G1 phase cells. The cytoprotective effects of FPEt were comparable with those of a positive control silymarin, a known hepatoprotective agent. The findings suggest that the polyphenolic compounds of fenugreek seeds can be considered cytoprotective during EtOH-induced liver damage.

PMID: 16574673 [PubMed - indexed for MEDLINE]


1: Pharmazie. 2007 Apr;62(4):299-304.Links
Fenugreek (Trigonella foenum graecum) seed polyphenols protect liver from alcohol toxicity: a role on hepatic detoxification system and apoptosis.Kaviarasan S, Anuradha CV.
Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, India.

The present study investigates the hepatoprotective effect of fenugreek seed polyphenolic extract (FPEt) against ethanol-induced hepatic injury and apoptosis in rats. Chronic ethanol administration (6 g/kg/day x 60 days) caused liver damage that was manifested by the elevation of markers of liver dysfunction--aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and gamma-glutamyl transferase (GGT) in plasma and reduction in liver glycogen. The effects on alcohol metabolizing enzymes such as alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) were studied and found to be altered in the alcohol-treated group. Ethanol administration resulted in adaptive induction of the activities of cytochrome p450 (cyt-p-450) and cytochrome-b5 (cyt-b5) and reduction in cytochrome-c-reductase (cyt-c-red) and glutathione-S-tranferase (GST), a phase II enzyme. Further, ethanol reduced the viability of isolated hepatocytes (ex vivo) as assessed by the trypan blue exclusion test and increased hepatocyte apoptosis as assessed by propidium iodide staining (PI). Treatment with FPEt restored the levels of markers of liver injury and mitigated the alterations in alcohol metabolizing and detoxification enzymes and the electron transport component cytochrome-c reductase. Increased hepatocyte viability and reduced apoptotic nuclei were observed in FPEt-treated rats. These findings demonstrate that FPEt acts as a protective agent against ethanol-induced abnormalities in the liver. The effects of FPEt are comparable with those of a known hepatoprotective agent, silymarin.

PMID: 17484288 [PubMed - indexed for MEDLINE]

1: Cell Biol Toxicol. 2007 Apr 24 [Epub ahead of print] Links
Fenugreek seed (Trigonella foenum graecum) polyphenols inhibit ethanol-induced collagen and lipid accumulation in rat liver.Kaviarasan S, Viswanathan P, Anuradha CV.
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, 608 002, India, [email protected].

Chronic alcoholism is associated with fatty liver and fibrosis characterized by collagen accumulation. Seeds of fenugreek, an annual herb, are reported to possess hepatoprotective activity. The study aims to investigate the effects of fenugreek seed polyphenol extract (FPEt) on liver lipids and collagen in experimental hepatotoxic rats. Hepatotoxicity was induced in male albino Wistar rats by administrating ethanol (6 g/kg per day) for 30 days. Control rats were given isocaloric glucose solution. FPEt was co-administered with ethanol at a dose of 200 mg/kg per day for the next 30 days. Silymarin was used as a positive control. Ethanol treatment caused increase in plasma and liver lipids, together with alterations in collagen content and properties. Administration of FPEt to alcohol-fed rats significantly improved lipid profile and reduced collagen content, crosslinking, aldehyde content and peroxidation. The effects were comparable with that of silymarin. FPEt administration had a positive influence on both lipid profile and on the quantitative and qualitative properties of collagen in alcoholic liver disease. The protective effect is presumably due to the bioactive phytochemicals in fenugreek seeds.

PMID: 17453353 [PubMed - as supplied by publisher]


1: Phytother Res. 2003 Aug;17(7):737-43. Links
Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity.Thirunavukkarasu V, Anuradha CV, Viswanathan P.
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, India.

The study investigates the effect of aqueous extract of fenugreek seeds (Trigonella foenum graecum) on lipid peroxidation and antioxidant status in experimental ethanol toxicity in rats. The ability of the seed extract to prevent iron-induced lipid peroxidation in vitro was also investigated. Ethanol feeding for 60 days resulted in significant increases in the activities of serum aspartate transaminase, alanine transaminase and alkaline phosphatase. The levels of serum lipid hydroperoxides and thiobarbituric acid reactive substances in liver and brain were also significantly elevated. Significantly lower activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase and glutathione reductase were observed in liver and brain accompanied by depletion in glutathione, ascorbic acid and alpha-tocopherol concentrations. Activity of Ca(2+) ATPase in brain was significantly lowered. Simultaneous administration of aqueous extract of fenugreek seeds with ethanol prevented the enzymatic leakage and the rise in lipid peroxidation and enhanced the antioxidant potential. The seeds exhibited appreciable antioxidant property in vitro which was comparable with that of reduced glutathione and alpha-tocopherol. Further, histopathological examination of liver and brain revealed that, aqueous extract of fenugreek seeds could offer a significant protection against ethanol toxicity. Copyright 2003 John Wiley & Sons, Ltd.

PMID: 12916070 [PubMed - indexed for MEDLINE]



healthy glucose levels and healthy sugar metabolism By
assisting the pancreas in production of insulin


the active compounds 4-hydroxyisoleucine In of fenugreek is an amino acid derivative that assists the pancreas in production of insulin. Studies have shown 4-hydroxyisoleucine reduces fasting blood sugars and improves after-meal glucose tolerance significantly. 4-hydroxyisoleucine works by two separate mechanisms: It has a direct, stimulating effect on insulin production for those who wish to increase their glucose metabolism and helps to reduce glucose resistance and the uptake of glucose, thereby reducing overall blood glucose levels. Several studies with animals and with human cell cultures demonstrate this extract’s positive effect on reducing postmeal glucose levels—with little or no increase in blood insulin concentrations— a clear indictor of improved insulin sensitivity

Several studies show that the free amino acid 4-hydroxyisoleucine plays a valuable role in insulin-promotion and glucose regulation. 4-hydroxyisoleucine stimulates insulin secretion, thereby limiting the extent to which blood glucose (the glycemic index) is elevated. Elevated blood glucose after meals leads to increased production of body fat. 4 hydroxyisoleucine promotes insulin secretion and inhibits the rise of blood glucose, thus helping to reduce body fat production. 4 -hydroxyisoleucine exhibits a specific effect on the islets of Langerhans in the pancreas. These cells are directly responsible for insulin production. Most significantly, the effect of 4-hydroxyisoleucine is glucose dependent. The higher the level of blood glucose, the greater the insulin-promoting response elicited by 4 hydroxyisoleucine. Thus 4-hydroxyisoleucine exhibits a significant regulating effect, which corresponds with the insulin needs of the body at any given time. This makes this compound “adaptogenic,” responding to the particular needs of the body at any given time

 

[Burpees]

why not run a lower dose of T3 and add T4?

 

[BodyND]

why not run a lower dose of T3 and add T4?

Is 50 mcg low enough for the t3 not to depresse my thyroid???