Sustanon 250 is a unique blend of 4 different esters of testosterone. The principle purpose of attaching an ester to a steroid is to make it more lipophillic, so that when injected intra-muscularly it can remain in the adipose tissue longer and is released in the blood-stream over time. The longer an ester, the more lipophillic it is. Sustanon 250 contain 1 short, 1 long and 2 medium length esters that are all delivered over time, which gives a quick release, but a durable one as well. You may think that this is a positive thing, and to patients requiring testosterone therapy this probably is, but to a steroid user its really not.
A steroid user will use a long-acting testosterone and inject it once a week. The end of a week is usually the time when a long-acting (7 or 8 carbon) ester has tapered down to its original level and threatens to drop below that level, giving sub-par amounts of testosterone beyond that point (eventhough the compound stays somewhat active for 3-4 weeks). With sustanon, that equal amount is divided much differently. Imagine a hypothetical situation where one take either 270 mg of a an ester that lasts 6 days, or 270 mg of a blend of different esters, 90 mg each, that release over respectively 2, 4 and 6 days, analog to sustanon. With the first one, an even amount of testosterone is released on each day. With the second one the entire first ester, half the second ester and 1/3rd of the last ester is released within the first two days. The result here is clear : the first two days one gets 165 mg, the next two one gets 75 mg and the last 2 days one gets a mere 30 mg. The levels peak much sooner, and drop off sooner, leaving you with less than adequate androgen levels as the week draws to a close.