I've taken accutane many times. The first time was the full blown 6 month regimen, non-roid induced acne when I was 21, took 80mg/day for 6 months-brutal but cleared everything up for about 2 years. Since than I when I'm going on a cycle for one week I take 40mg/day, than every week after take 40mg/every 3rd day and my skin is crystal clear. I used to date a dermo, she took a 10mg tab every 3rd day for over 2 years. She said that a very low dose over an extended periods is a very good treatment for people that don't have severe cystic acne, she called it the hollywood regimine(we lived in Los Angeles). Very low sides and great results for general acne. IF YOU DO HAVE severe cystic acne on face, shoulders, chest, etc...get a 2nd opinion because you should be on a higher dose. But I'm talking severe, the kind of guys you look at and just go "damn" there's more zit than there is skin on that guy. But if you're just a pizza face, the 20mg/ 3 days week should do you right.