5-alpha Reduction and Tren

[HyaSynth]

Let's clear up one basic fact. Trenbolone _does not_ get reduced to DHN by the 5a Reductase enzyme! First off, if a steroid is going to be reduced by the 5a Reductase enzyme you need a double carbon bond between the 4th and 5th position. The enzyme then breaks this bond and adds a hydrogen molecule at the 5th alpha postion (Hence the name). Therefore any steroid with a double bond at the 4th position can be reduced, unless there any other bonds that would obscure the enzyme from attaching. Nandrolone, 4-ESTREN-17b- OL-3-ONE, gets converted to 5a-ESTREN-17b- OL-3-ONE (DHN) by 5a Reductase. Whereas Trenbolone, 4,9,11-ESTRATRIEN-17b-OL-3-ONE, gets converted to 5a-9,11-ESTRATRIEN-17b-OL-3-ONE (I don't know the trivial name off hand) by the 5a Reductase. Chemically speaking there is a huge difference between the two. If anyone has Vida's book in front of them they could look up the potency. For Trenbolone to be converted to DHN there would be many multiple metabolic steps which in turn would decrease the amount of DHN. Notice the double carbonds at the 9th and 11th position which Nandrolone does not have.

 

[TxLonghorn]

At the risk of sounding daft, what does this mean in terms of gains, usage, things to look out for, benefits, etc.

 

[HyaSynth]

bumb

 

[TxLonghorn]

Hyasynth, any answers on what this means in terms of how to best utilize fina?

 

[LewdTenant]

here we go again!

 

[panerai]

Finally we cleared it up....
Thank you, for the research!
For guys who asked, it means that you can use Tren with Proscar( Propecia) without fear that your hairloss will get much worse!
On the other hand, if you are prone to MPB, you shouldn't use Tren at all!
Anabolicum Mister was right!

 

[GAAV KOSH]

Panerai, how does this mean that you can use finasteride with tren? If what Hya says is right, it still means that trenbolone gets 5alpha reduced, just not to dhn. This means finasteride will stop the conversion. What would be great to know is how much androgenic activity trenbolone has in the scalp compared to when it's 5alpha reduced.

 

[HyaSynth]

I checked "Androgens and Anabolic Agents" and couldn't find either Trenbolone or 5a,9,11-ESTRATRIEN-17b-OL-3-ONE. Interestingly I found a 17AA version of Trenbolone, which seems to be quite potent...

TxLonghorn, since I don't know what the exact strength of 5a,9,11-ESTRATRIEN-17b-OL-3-ONE is, I couldn't tell you what effect finasteride would have. Since anecdotal reports say that Finasteride does not increases Trenbolone's potency, I would guess that 5a,9,11-ESTRATRIEN-17b-OL-3-ONE is weaker/stronger/neutral to some degree.

 

[MadCow1]

This is true but we are one step closer to an answer.

 

[TxLonghorn]

Interestingly I found a 17AA version of Trenbolone, which seems to be quite potent...

(ears perking up, all excited-like) yes, and...