1-AD Spray? (Question for PA, Par or Bill)

[u4ik_RAGE]

I haven't heard anyone pose this question:
Would throwing some 1-AD powder into Andro-Spray (or similar ethanol and isopropyl myristate formula without the 4-AD) help with the somewhat pour absorption?

This seems like a logical conclusion with how much better the 4-AD and 19-nor sprays are over the pill form and also with the effectiveness of One and One+.

And if this were to "work," I'm guessing it would be okay to take without food and users wouldn't have to worry to take it with food (not like that is a huge issue to have a little snack).

 

[Bill Llewellyn]

I haven't heard anyone pose this question:
Would throwing some 1-AD powder into Andro-Spray (or similar ethanol and isopropyl myristate formula without the 4-AD) help with the somewhat pour absorption?

This seems like a logical conclusion with how much better the 4-AD and 19-nor sprays are over the pill form and also with the effectiveness of One and One+.

And if this were to "work," I'm guessing it would be okay to take without food and users wouldn't have to worry to take it with food (not like that is a huge issue to have a little snack).

I haven't tried this myself, but would think it to offer some value due to the relatively (still much better than 4-andro) low oral bioavailability of the 1-andro series. I know Pat disagrees, and says he has had unremarkable feedback with sample 1-AD dermals.

If you are going for the dermals though, it would be much smarter to just go with 1-test. This would clearly be more potent.

- Bill

 

[Par Deus]

Given how well 1-AD has stacked up with 1-test orally, I would think that some of the 1-AD is being converted to 1-test by the liver (when 4-AD, etc. would be metabolized to 17-keto steroids (i.e. deactivated) -- I have the urinary metabolite paper but can't seem to locate it of late..... perhaps PA can comment.

This would not occur with transdermal administration.

 

[Bill Llewellyn]

Given how well 1-AD has stacked up with 1-test orally, I would think that some of the 1-AD is being converted to 1-test by the liver (when 4-AD, etc. would be metabolized to 17-keto steroids (i.e. deactivated) -- I have the urinary metabolite paper but can't seem to locate it of late..... perhaps PA can comment.

This would not occur with transdermal administration.

They actually looked at 1-test in the same study, and its 17b-oh excretion was relatively high (about 24%). Logic would dictate also that having only one open hydroxyl group instead of two, which are open to conjugation, 1-test should have a little (probably not significant) better oral bioavailability than 1-AD. I don't think this is the issue, at least when comparing the effectiveness of oral 1-AD and 1-Test ether products.

I think the difference in efficacy has more to do with the dose, as 100mg of 1-test THP is only roughly 79mg of 1-test base. The benifit disparity further supports my belief that without dissolving the steroid in oil you have no real improvement in oral bioavailability with ethers, otherwise the 79mg would strongly outperform 1-AD, which does not appear to be the case.