Why Deca lubricate joints, but Tren or Anadrol don't?

[panerai]

I assume, that Nandrolones lubricate joints by increased water retention, because of PR binding. Then, why Trenbolone doesn't do the same, it has very high affinity to PR, and why Anadrol causes huge water retention, also because of PR binding, but don't lubricate joints?
If just simple water retention makes joints more lubricated, then why Test and dbol are not great lubricants?
Only Deca, why?

 

[Strong_Man20]

good point!! I always wondered this my self, ill bump this for you

 

[liftsiron]

I know that deca works better for my shoulders than anything else, I am also would like to know why. It can't be because of water, that's not it.

 

[Maxx Out]

All deca does for me is make my nips itchy! Doesn't help w/my joints at all... .

 

[browndog1]

I hate deca.

...bd

 

[Ulter]

I am guessing. I might as well this question has been asked for a week now and no one has answered it I don't think it is only the water that brings relief.
I think it is due to nandrolones ability to increase bone mineral density. When the bone is degenerating due to fracture, crushing, osteoporosis etc., ND reverses this condition and actually adds BMD. I would think adding thickness to the bone would make it stronger and thereby relieve the pain.

 

[liftsiron]

But why does it work to relieve soft tissue pain i.e. tendon and ligamint?

 

[GrowthPro]

***I think it might have something to do with the increased endogenous production of the jelly type lubrication substances between our joints called glucocosamine sulfate and chrondroiten, due to the Deca and other nandrolone preparations...I am not 100% sure though, just a hypothesis...-GPro

 

[inlarge]

Bump

 

[HUCKLEBERRY FINNaplex]

Here's a couple of the research study's that Ulter was alluding to...

Nandrolone decanoate for men with osteoporosis.

Hamdy RC, Moore SW, Whalen KE, Landy C

James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN USA.

To compare the efficacy and safety of nandrolone decanoate and calcium (NDC) with those of calcium alone (CAL) in men with idiopathic osteoporosis, a 12-month, randomized, prospective, controlled study, was performed in an outpatient clinic. Twenty-one men with idiopathic osteoporosis (as determined by radiological and dual energy x-ray absorptiometry findings) were randomly allocated to either 50 mg nandrolone decanoate intramuscularly (im) weekly and 1,000 mg oral calcium carbonate daily (NDC group) or to 1,000 mg oral calcium carbonate daily (CAL group). Bone densitometry (total body, left femur, and lumbar spine), serum, and urine biochemical parameters were measured at 3-month intervals. In the NDC group, bone mineral density initially increased, reached a plateau, and then decreased to near baseline levels at 12 months. Increases in lean muscle mass mirrored these changes. Free and total testosterone significantly decreased. Hemoglobin increased in all patients in this group. Patients in the CAL group exhibited no significant change in either total body or bone mineral density or biochemical parameters. Thus, nandrolone decanoate, 50 mg im weekly, transiently increases the bone mass of men with idiopathic osteoporosis in this preliminary study. Careful monitoring is necessary.

Publication Types:
Clinical trial
Randomized controlled trial

PMID: 10099043, UI: 20091252

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Nandrolone decanoate: pharmacological properties and therapeutic use in osteoporosis.

Geusens P

Arthritis and Metabolic Bone Disease Research Unit, Katholieke Universiteit Leuven, Pellenberg, Belgium.

The therapeutic profile on bone of nandrolone decanoate is that of inhibitor of bone resorption with temporary increase in bone formation, followed by an absence of suppression of bone formation, indicating uncoupling of bone resorption and formation. This results is an increase in bone mineral content at the proximal and distal radius, and in some patients at the lumbar spine. Furthermore, nandrolone decanoate increases calcium balance and muscle mass, diminishes vertebral pain and increases the mobility of the spine.
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Long-term effect of nandrolone decanoate, 1 alpha-hydroxyvitamin D3 or intermittent calcium infusion therapy on bone mineral content, bone remodeling and fracture rate in symptomatic osteoporosis: a double-blind controlled study.

Geusens P, Dequeker J

Department of Internal Medicine, K.U. Leuven, Pellenberg, Belgium.

A double-blind controlled study was performed in 60 patients with symptomatic osteoporosis with at least one vertebral crush fracture, comparing the effect of nandrolone decanoate, 1 alpha-hydroxyvitamin D3 and intermittent calcium infusions. Thirty-four out of 60 patients completed the 2 year observation period. Nandrolone decanoate statistically significantly increased the bone mineral content at the radius, reduced the endosteal bone loss at the metacarpals and statistically significantly reduced urinary calcium and hydroxyproline excretion. Calcium infusions and 1 alpha-hydroxyvitamin D3 inhibited further loss of bone mineral content, but endosteal bone loss continued. In the second year fracture rate was reduced in the nandrolone decanoate groups compared to the two other groups. We conclude that nandrolone decanoate is an active drug for increasing bone mineral content and reducing endosteal bone loss, while 1 alpha-hydroxyvitamin D3 and calcium infusions only stop further bone mineral loss at the radius but do not inhibit endosteal bone loss as measured at the metacarpals and that single photon absorptiometry and radiography are complementary in interpreting cortical bone mineral changes.

Publication Types:
Clinical trial
Controlled clinical trial