In the quest to cure erectile dysfunction in men, the drug Alprostadil has been frequently used by needle injection or by placing a small pellet into your urethra. Ouch! Now a new and easy to use topical cream called Topiglan could make these two methods of using Alprostadil history.
It seems as if there isn’t a person alive who hasn’t seen a Levitra or Cialis commercial on TV. Previously, the market for the treatment of erectile dysfunction (ED) has been dominated by these oral medications. But it has been discovered that in many of these orally administered drugs the side effects can outweigh the benefits in many people and in some guys, the oral meds just don\'t do the trick. This had led to many pharmaceutical companies searching for alternative treatments for ED such as the use of the drug Alprostadil.
For those who are familiar with Alprostadil, the mention of its name probably brings to mind several thoughts. The most common one may be how the prostaglandin Alprostadil works and this is by causing increased blood flow throughout the body by opening blood vessels. Unfortunately, some other thoughts that Alprostadil can bring up revolves around things that we don’t like to think about much such as pain, burning, and even needles.
More of the current methods of Alprostadil administration.
Perhaps the most radical method of producing an erection is the use of the adult film star\'s drug of choice, Caverject. Caverject is injected with a fine needle into the side of the penis where the erection forms (the Corpus Cavernosum). Although this sounds unpleasant, most men find the injections virtually painless, as the shaft of the penis is relatively insensitive. Only a single injection is necessary, as the drug is rapidly distributed throughout the penis.
An erection will usually develop 5-20 minutes after injection and is intended to last for several hours. Caverject causes an erection firm enough for sexual intercourse in approximately 80% of men, regardless of their age or the cause of their erectile dysfunction.
In fact, Caverject produces perfect erections — with or without sexual excitement. And because it is so effective, Caverject is used by adult film models during production. In fact, I am told that several studios include money in their video budgets for supplies of Caverject and/or Viagra (often for men in their late teens or early 20\'s). Other companies place the responsibility on the models by stipulating in their contract that an erection must be maintained during the hours of the shoot or the model will not be paid in full.
One of the more exotic treatments for producing erections is a penile suppository sold in Europe under the brand name Muse. Treatment involves the insertion of a hollow plastic applicator, which contains a suppository of the drug, Alprostadil, about 1 inch into the urethra of the penis. The Alprostadil is then deposited in the urethra and absorbed by the surrounding tissue, called the Corpus Spongiosum.
Alprostadil is known to cause an erection by relaxing the smooth muscle within the penis, and this action allows blood to enter and become trapped in the penis.
These unpleasant subjects are often associated with Alprostadil delivery mainly due to the common methods through which the drug is used and their major drawbacks. One of these methods is penile injection or, in other words, sticking a small needle into your penis. Problems associated with the injection method include pain and burning at the injection site, priapism or erections that last for more than four hours, scarring of the penis for those who use the drug for more than a year, and the cringe that comes with stabbing your penis with a needle.
So there must be a better way to use Alprostadil than the injection method. And yes, there is a better way but it’s certainly not by depositing a pellet in your urethra. This method involves using a plastic tube or syringe-like apparatus to put a suppository into your urethra and can cause a host of grimacing side effects. Some of them are burning in the urethra, low blood pressure, bleeding, redness of the penis, and aching in the testicles. Thankfully, a third method of using Alprostadil is on the horizon.
This method won’t force guys to explain the weird scars on their penis to new girlfriends, shove tubes in their urethra, or get lightheaded when they see blood coming out of their pee hole. It’s called Topiglan and it is a topical cream that employs the use of Alprostadin to stimulate the penis just like the injection and suppository methods. And not only does Topiglan use the prostaglandin Alprostadin but it combines the drug along with a skin absorption agent known as SEPA to produce its erection promoting effects.
The best part about Topiglan is the way in which it is applied. It is simply rubbed on the tip of the penis in order to deliver the benefits of Alprostadin. The ease with which Topiglan can be used almost seems too good to be true. In fact, many people don’t believe that a simple cream can have the same effectiveness of the injection or suppository methods and have questioned its legitimacy.
This is where clinical proof of the cream’s power to cure ED comes into play. A trial was conducted by Dr. Irwin Goldstein, Professor of Urology at the Boston University Medical School. Dr. Goldstein, who is one of the United State’s best recognized authorities on the subject of sexual dysfunction, used 60 men in his study and 97% of them suffered from ED because of a vascular condition.
These men were either given Topiglan or a placebo cream for use in the study. According to a quote by Dr. Goldstein results were certainly produced by the cream despite the lack of certain artificial aids. "No soft lights, no music, not even a partner and yet, within 45 to 60 minutes of application, almost 40 percent of the impotent men receiving Topiglan produced erections judged sufficient for intercourse, versus less than 7 percent receiving a placebo gel," said Dr. Goldstein.
The study showed that Topiglan certainly won’t work on every male with erectile dysfunction but it did do its job on nearly half of those tested. And it is important to note that these weren’t just any patients either. They were people with ED that other doctors had difficulty in treating with the more mainstream orals. Dr. Goldstein summed this up by saying, "These patients were difficult cases referred to me by other practitioners. Before being treated with Topiglan, some men in the trial could obtain an erection only with one or more vasodilators injected directly into their penises."
Judging from this statement by Irwin Goldstein, it could be possible that Topiglan could work on over half of all men who just have an average case of erectile dysfunction. The prospect of being able to produce an erection just from simply rubbing a cream on the penis has definitely gotten some people excited ─ literally. And the only noticeable side effect from the use of Topiglan was complaints of mild burning of the penis (later studies that have used female partners to have sex with the patients also complained of mild vaginal burning).
The ease of use coupled with a limited number of side effects should mean that Topiglan will be flying off of the shelves by now. However, this product is no different from any other new erectile dysfunction treatment in that it will have to survive years of testing and FDA scrutiny before it’s considered safe for the public. After all, Topiglan has been around since the late 1990’s but has still never been FDA approved.
So for now, it still looks as if the big three ED treatments, which are Viagra, Cialis, and Levitra, will continue to keep a tight grip on the industry. But it is reassuring that there are companies out there that are trying to improve the methods of use and selection of erectile dysfunction drugs that are available. Who knows, maybe the approval of a new ED treatment with minimal side effects such as Topiglan is right around the corner.
Yours in sport,
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