HCG-induced Leydig cell desensitization permanent?

[Necromancer44]

Also called HCG-induced LH receptor down regulation as a result of using too much hcg or for too long. Should it happen, will it stay forever, or will it eventually go away?

I have heard some speak of there being 2 types of Leydig cell desensitization, one that is temporary and one that is permanent.

What is a safe range of HCG use during PCT - post cycle therapy - to avoid this while also avoiding injections that are too frequent (like everyday)?

 

[dmc777]

Your best bet is to run it in smaller dosages throughout the whole cycle starting about week 3. I'd use 250ius twice weekly. Use for a month, take a 2 week break, and use again for another month.

 

[centeroiler]

Both Nolvadex and FSH have been shown in studies to help prevent and reverse desensitization.