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Hi Maximus,
First of all it's Buffdoc, NOT Puffdoc (you really know how to ask for assistance! ;-) Sorry it took me so long to answer.
Actually, most of the questions are answered in one form or another in my posts earlier in the thread. But there are some misconceptions you have that I'll try to remedy.
First off, minoxidil does NOT work by inhibiting conversion to DHT (it is an extremely weak 5-AR inhibitor) It is a potassium channel opener. It's exact mechanism is unknown, but it may have to do with changes in blood flow, temperature, or a direct effect on the hair.
Also, you state with certainty that finasteride will decrease DHT levels in BB's to the point that gains will be affected. This has not been shown. In fact, we don't really even know if finasteride will keep DHT levels down within the normal range when BB's are using high doses of test. The data accumulated has been in men with "normal range" levels of test, NOT the supraphysiological levels achieved when juicing! Keep in mind also, that testosterone may be the biggy at the myocyte or muscle cell, and NOT DHT. So the gains thing doesn't hold up well.
However, finasteride WILL inhibit the formation of any 5-alpha reduced intermediate, whether from test, or any other androgen than undergoes 5-alpha reduction (eg, nandrolone to DHN). It's not exclusively testosterone. I'm not sure what the metabolic/enzymatic pathway of boldenone is.
You are wrong again in your statement about nizoral and minoxidil preventing the binding of DHT to the hair follicle. We are not sure what Nizoral does, but we know minoxidil has nothing to do w/ DHT binding to follicles. So the argument about using this combo instead of finasteride for the given reason is illogical. That being said, I'm all for Nizoral during cycling, use it myself.
Now, to answer your numbered questions above:
#1 No, they don't make sense (sorry;-)
#2 Sometimes proscar DOES work frontally, it's just been shown to work better and more predictably in the crown
#3 This question doesn't really follow given your previous question, but again, it MAY help frontally
#4 My friend, the reasoning here is just not present. First of all, as I have posted numerous times on numerous threads on this board, neither minox or finast can be used effectively in an intermittent fashion. Three things are required for androgenetic alopecia to occur:
1)genetic predisposition
2)presence of androgen (the most proven being DHT)
3)passage of time
If you are prone to balding, or are concerned about hair loss, get on finasteride (preferably with minoxidil), titrate your dose of finasteride down if you have sides, and STAY ON IT! Cycle or no cycle! If it does provide you with protection, and you stop it, your hair counts will go to where they would have been genetically if you'd never used the hair loss meds at all. Don't worry; other, better meds will be along soon. But once again, to anyone who reads this: intermittent use of minxidil and/or finasteride during cycles only is a waste of time and $$! Your own "normal" non-cycling levels of androgen are more than enough to facilitate male pattern baldness if you are so disposed. If you're not, 2 grams a week aren't going to affect you!
And once again, I believe a lot of the sudden hair loss people seem to experience using Fina, Wimmy, Primo, Proviron, or whatever else, is not AGA, but stress or chemical induced telogen effluvium.
First of all it's Buffdoc, NOT Puffdoc (you really know how to ask for assistance! ;-) Sorry it took me so long to answer.
Actually, most of the questions are answered in one form or another in my posts earlier in the thread. But there are some misconceptions you have that I'll try to remedy.
First off, minoxidil does NOT work by inhibiting conversion to DHT (it is an extremely weak 5-AR inhibitor) It is a potassium channel opener. It's exact mechanism is unknown, but it may have to do with changes in blood flow, temperature, or a direct effect on the hair.
Also, you state with certainty that finasteride will decrease DHT levels in BB's to the point that gains will be affected. This has not been shown. In fact, we don't really even know if finasteride will keep DHT levels down within the normal range when BB's are using high doses of test. The data accumulated has been in men with "normal range" levels of test, NOT the supraphysiological levels achieved when juicing! Keep in mind also, that testosterone may be the biggy at the myocyte or muscle cell, and NOT DHT. So the gains thing doesn't hold up well.
However, finasteride WILL inhibit the formation of any 5-alpha reduced intermediate, whether from test, or any other androgen than undergoes 5-alpha reduction (eg, nandrolone to DHN). It's not exclusively testosterone. I'm not sure what the metabolic/enzymatic pathway of boldenone is.
You are wrong again in your statement about nizoral and minoxidil preventing the binding of DHT to the hair follicle. We are not sure what Nizoral does, but we know minoxidil has nothing to do w/ DHT binding to follicles. So the argument about using this combo instead of finasteride for the given reason is illogical. That being said, I'm all for Nizoral during cycling, use it myself.
Now, to answer your numbered questions above:
#1 No, they don't make sense (sorry;-)
#2 Sometimes proscar DOES work frontally, it's just been shown to work better and more predictably in the crown
#3 This question doesn't really follow given your previous question, but again, it MAY help frontally
#4 My friend, the reasoning here is just not present. First of all, as I have posted numerous times on numerous threads on this board, neither minox or finast can be used effectively in an intermittent fashion. Three things are required for androgenetic alopecia to occur:
1)genetic predisposition
2)presence of androgen (the most proven being DHT)
3)passage of time
If you are prone to balding, or are concerned about hair loss, get on finasteride (preferably with minoxidil), titrate your dose of finasteride down if you have sides, and STAY ON IT! Cycle or no cycle! If it does provide you with protection, and you stop it, your hair counts will go to where they would have been genetically if you'd never used the hair loss meds at all. Don't worry; other, better meds will be along soon. But once again, to anyone who reads this: intermittent use of minxidil and/or finasteride during cycles only is a waste of time and $$! Your own "normal" non-cycling levels of androgen are more than enough to facilitate male pattern baldness if you are so disposed. If you're not, 2 grams a week aren't going to affect you!
And once again, I believe a lot of the sudden hair loss people seem to experience using Fina, Wimmy, Primo, Proviron, or whatever else, is not AGA, but stress or chemical induced telogen effluvium.
