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fleabag711
New member
Okay, I'm trying to consider that if my free Test levels are greater, than I will have greater gains. Winstrol is supposed to reduce SBGH (sex hormone binding Globulin) by 50% right. I found a conflicting study on rat's that some people argue SBGH is necessary? Am I reading this right? Anyone know what the latest facts are on Free Testosterone?? Here is where someone puts the results in lamens terms at the bottom.
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“recently presented convincing evidence that androgens and estrogens in complex with their carrier protein, the sex hormone binding globulin (SHBG), are endocytosed in cultured cells expressing megalin. The presence of accessible megalin appears to be necessary for optimal internalization of these steroid-SHBG complexes, as evidenced by the reduced levels of uptake observed when receptor-associated protein (RAP, an antagonist of ligand binding to megalin) or megalin-specific antiserum was added, or in cells that lack megalin expression. Furthermore, transcriptional activation (the hallmark of intracellular steroid action) of an androgen-sensitive reporter was observed when androgen-SHBG complexes were added to megalin-expressing cells in vitro; this activity was also inhibited by the addition of RAP”
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This way if you arrest all the sbgh (imposible to do because proviron –mesterolone- and winstrol –stanozolol- called shbg inhibitors, binders, competitors etc, are androgens.) you are negating androgens to the cell. the same thing for the nettle (lignans), maybe they bind to shbg but remember there is more sbhg thanks to it (lignans), and I don't deny that it could bind to the shbg.
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“recently presented convincing evidence that androgens and estrogens in complex with their carrier protein, the sex hormone binding globulin (SHBG), are endocytosed in cultured cells expressing megalin. The presence of accessible megalin appears to be necessary for optimal internalization of these steroid-SHBG complexes, as evidenced by the reduced levels of uptake observed when receptor-associated protein (RAP, an antagonist of ligand binding to megalin) or megalin-specific antiserum was added, or in cells that lack megalin expression. Furthermore, transcriptional activation (the hallmark of intracellular steroid action) of an androgen-sensitive reporter was observed when androgen-SHBG complexes were added to megalin-expressing cells in vitro; this activity was also inhibited by the addition of RAP”
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This way if you arrest all the sbgh (imposible to do because proviron –mesterolone- and winstrol –stanozolol- called shbg inhibitors, binders, competitors etc, are androgens.) you are negating androgens to the cell. the same thing for the nettle (lignans), maybe they bind to shbg but remember there is more sbhg thanks to it (lignans), and I don't deny that it could bind to the shbg.
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