only side was very sore joints @ 50 mgs EOD (both knees, elbows, and rt wrist). i couldnt go as heavy as my strength would permit b/c of the soreness in my joints. ive been off for 3 1/2 mos and joints feel better so i can go heavier, and i'm actually stronger now b/c of that. i'm not as detailed as when on, but overall the gains were very well maintained. u have to deal w/ the pain, but winny's still my favorite!