Why Would High Dose Test Cause Hairloss?

[KD1]

It seems like a simple answer - but upon further thinking maybe not so much.

Lets say you are running 2g test a week - about 15-20x what your body would make. You would assume that there would be 15-20x the DHT floating around and your hair would fall out.

Well, since the levels of 5-AR have not changed, then there would be no way to get that much DHT in your blood! Unless your body can be stimulated to produce more 5-AR enzyme, there is no way to get higher DHT levels.

Also, Ive read that your body has some sort of defense against high DHT by making it inactive with some other enzyme ( 3bHSD ), so even if higher than normal levels are around, they get zapped by your system.

Makes me wonder if its other steroids binding directly to scalp receptors ( for instance DHT based orals, or perhaps just other 5-AR reduced by products of other injectibles ) that cause quicker hairloss when on cycles.

Any thoughts by the experts?

 

[lanky]

testosterone in high concentrations can make your MPB progress even with minimal reduction to dht

when in increasing doses of testosterone administration there is an increase in DHT, Estrogen, and testosterone metabolites( androstenedione, androstenediol, 5 alpha reduced metabolites 3alpha diol ,etc...) i do not know if it is a linear relationship between DHT and increasing amounts of testosterone..probably more of a curve as i picture it in my mind on a graph when you increase the amounts up to the 2g a week.

i understand where you are coming from with the whole 3HSD idea..it is a very good question..3HSD and 17HSD metabolic pathways are capable of reversable action...example... 3HSD can turn the 3 keto on dht to a hydroxy(3 alpha diol)..it can also turn the 3alpha diol back into DHT...there is also some "types" of 3HSD that act like 17HSD and act on the 17 hydroxy group on most steroids turning them into a keto( the body is an amazing and complex thing that boggles my mind)

the scalp is full of androgen receptors(as is everywhere else on your body pretty much)..there has been debate on other synthetic 5 alpha reduced androstanes causing hairloss..we are dealing with synthetic steroids which most have greater anabolic activity than testosterone(what they were made for)...unfortunatly they also have greater androgenic activity and lower surum testosterone levels while you take the steroids causing decreased estrogen/estradiol levels which also have an impact on the hair growth cycle. hairloss is a subjective thing and everyone reacts different to different compounds...sometimes i am a little leary that some substances people are getting is not what they ordered

winny may be proviron or 17 alpha methyl dht (was noted before)

d-bol may actually be 17alpha methyl testosterone

halotestin may be caffiene mixed with an androgen

GH may be insulin or ascorbic acid powder

DECA my be a corticosteroid mixed with a nandrolone ester(i have seen documents on this one)(hmm deca bloat or corticosteroid bloat) now wonder everyones joints feel good.

dont get me started on the whole cheque drop issue..lol

 

[thelion2005]

I applaud the explaination above. Personal experience has been as follows.

I took dbol as a skinny teen and my MPB started to kick in.

I did 2 different cycles this year at 62 and watched what I have left get thinner. During the rest period, my hair got thicker and some growth came in on top.

My blood testing showed my test and DHT through the roof ... PSA too.
Now they are down.

Got to be a connection.