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whats the logic behind taking it in the am and pm if it has a half life of 50 hours.
why take bromo twice a day
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frorider6
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Plasma half life - 15 hours
For hyperprolactinoma dose of 1.25 mg every 8-12 hours (total of 2.5 mg ed)
http://www.infomed.org/100drugs/frames/bromfram.html
I was taking 2.5 mg in the morning (starting yesterday). I'll break them and take 1.25 mg 2x a day now.
For hyperprolactinoma dose of 1.25 mg every 8-12 hours (total of 2.5 mg ed)
http://www.infomed.org/100drugs/frames/bromfram.html
I was taking 2.5 mg in the morning (starting yesterday). I'll break them and take 1.25 mg 2x a day now.
perfectspecimen
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lone-az said the half life was 50 hours.
which one is correct
which one is correct
perfectspecimen
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perfectspecimen
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which is it, 3hrs, 15hrs or 50 hours. there should be one answer.
frorider6
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Well, this reference says half life is 3 hours. 
http://www.parkinsons-information-exchange-network-online.com/drugdb/020.html
http://www.parkinsons-information-exchange-network-online.com/drugdb/020.html
Here is what the PDR says. I should have given you this information in the first place.
Peak plasma concentration: 1-3 hr. t1/2, plasma: 6-8 hr; terminal: 15 hr. Duration, lower prolactin: 24 hr (after a single dose)
Realistically you will see some action at 24 hr dosing but probably not enough to make a difference so that is why you need twice day dosing.
**Only go to 1.25 TD given you do not have a pituitary tumor***
Peak plasma concentration: 1-3 hr. t1/2, plasma: 6-8 hr; terminal: 15 hr. Duration, lower prolactin: 24 hr (after a single dose)
Realistically you will see some action at 24 hr dosing but probably not enough to make a difference so that is why you need twice day dosing.
**Only go to 1.25 TD given you do not have a pituitary tumor***
frorider6
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Another reference:
http://www.nursespdr.com/members/database/ndrhtml/bromocriptinemesylate.html
Action/Kinetics: Nonhormonal agent that inhibits the release of the hormone prolactin by the pituitary. Use only when prolactin production by pituitary tumors has been ruled out. Effect in parkinsonism is due to a direct stimulating effect on dopamine type 2 receptors in the corpus striatum. Use for parkinsonism may allow the dose of levodopa to be decreased, thus decreasing the incidence of severe side effects following long-term levodopa therapy. Less than 30% of the drug is absorbed from the GI tract. Onset, lower prolactin: 2 hr; antiparkinson: 30-90 min; decrease growth hormone: 1-2 hr. Peak plasma concentration: 1-3 hr. t1/2, plasma: 6-8 hr; terminal: 15 hr. Duration, lower prolactin: 24 hr (after a single dose); decrease growth hormone: 4-8 hr. Significant first-pass effect. Metabolized in liver, excreted mainly through bile and thus the feces.
http://www.nursespdr.com/members/database/ndrhtml/bromocriptinemesylate.html
Action/Kinetics: Nonhormonal agent that inhibits the release of the hormone prolactin by the pituitary. Use only when prolactin production by pituitary tumors has been ruled out. Effect in parkinsonism is due to a direct stimulating effect on dopamine type 2 receptors in the corpus striatum. Use for parkinsonism may allow the dose of levodopa to be decreased, thus decreasing the incidence of severe side effects following long-term levodopa therapy. Less than 30% of the drug is absorbed from the GI tract. Onset, lower prolactin: 2 hr; antiparkinson: 30-90 min; decrease growth hormone: 1-2 hr. Peak plasma concentration: 1-3 hr. t1/2, plasma: 6-8 hr; terminal: 15 hr. Duration, lower prolactin: 24 hr (after a single dose); decrease growth hormone: 4-8 hr. Significant first-pass effect. Metabolized in liver, excreted mainly through bile and thus the feces.
perfectspecimen
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here is what i am doing let me know if it will lower prolactin enough to be safe.
week 1-4 1.25mg/ed split into two doses of .625 or so.
week 5-6 2.5mg/ed split into two doses of 1.25mg
is that enough or should i buy another 30 tabs?
week 1-4 1.25mg/ed split into two doses of .625 or so.
week 5-6 2.5mg/ed split into two doses of 1.25mg
is that enough or should i buy another 30 tabs?
frorider6
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I jumped in with 5 mg in the morning yesterday and today. I feel a bit odd but I think it's becuase I might be a tad sick (felt like this since Sunday). I haven't had the stomach sides yet. Maybe that will change with a more a more even blood level.
I think this is a pretty unknown drug and it's great that we can have these conversations.
Did you see in any of the articles you looked at that they might be able to use this to treat sexual problems? Not so much mechanically like Viagra, but by making the brain more receptive to stimulation. Interesting.
I think this is a pretty unknown drug and it's great that we can have these conversations.
Did you see in any of the articles you looked at that they might be able to use this to treat sexual problems? Not so much mechanically like Viagra, but by making the brain more receptive to stimulation. Interesting.
perfectspecimen
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my nipples are puffy to begin with.
i want to get rid of the excess prolactin in my system before i start.
if i am on fina for 6 weeks at 75mg a day
what would u recommend.
bromo from weeks 1-6 or 1-7
are my doses enough or should i buy more bromo
i am only doing half a pill a day for the first four weeks
i want to get rid of the excess prolactin in my system before i start.
if i am on fina for 6 weeks at 75mg a day
what would u recommend.
bromo from weeks 1-6 or 1-7
are my doses enough or should i buy more bromo
i am only doing half a pill a day for the first four weeks
perfectspecimen
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i am doing a 13 week cycle with fina at the end for 6 weeks at 75mg a day.
perfectspecimen
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SirWanksalot
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http://www.fda.gov/ohrms/dockets/ac/98/transcpt/3408t2.rtf
""Bromocriptine represents a new class of diabetes oral medications believed to work by resetting metabolic activity that would improve glucose tolerance as well as reduce body weight. Obesity and glucose intolerance are significant factors in contributing to Type 2."
The key point is that in the diabetics as you'll see in the next slide, the daytime levels of prolactin are elevated in the diabetic population versus the non-diabetic population. And we used that time of day when there was this elevation in prolactin to represent a time of decreased dopaminergic tone and that's where we gave the dopamine agonist.
Elevated diurnal prolactins; no change in the nocturnal situation. So we timed the bromocriptine or the ErgocetTM to the early morning. The next slide goes over the next aspect of this Phase 2 study program looking at the threshold dose rationale.
""Bromocriptine represents a new class of diabetes oral medications believed to work by resetting metabolic activity that would improve glucose tolerance as well as reduce body weight. Obesity and glucose intolerance are significant factors in contributing to Type 2."
The key point is that in the diabetics as you'll see in the next slide, the daytime levels of prolactin are elevated in the diabetic population versus the non-diabetic population. And we used that time of day when there was this elevation in prolactin to represent a time of decreased dopaminergic tone and that's where we gave the dopamine agonist.
Elevated diurnal prolactins; no change in the nocturnal situation. So we timed the bromocriptine or the ErgocetTM to the early morning. The next slide goes over the next aspect of this Phase 2 study program looking at the threshold dose rationale.
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perfectspecimen
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perfectspecimen
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how much bromo is needed to significantly lower prolactin
gearedup50
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Is this by prescription? Never used it before? Someone can pm me where to get it that would be great, thanks!
