Why purity is so important in R-ALA.....explained

[Fonz]

Might as well make a post out of this:

We have two products. A 100% r-ala blend and a less than 100% r-ala blend.

THIS IS ONLY IN TERMS OF GLUCOSE CLEARANCE.

Assume non 100% R-ALA = (s + r) (S-ALA + R-ALA)
Assume R-ALA = R = (1r) (100% R-ALA)

Set each equal to one another in terms of glucose disposal.
(But multiply racemic times 3...see my glucometric study)
(My in vivo glucometric studies demonstrated this. Link here:

http://boards.elitefitness.com/forum/showthread.php?threadid=235805

(This was for a 50%/50% Racemic product i.e. Kilosports btw)

(s + r) * 3 = 1r
So, all things being equal:

3s + 3r = 1r

3s = - 2r
r = - 3/2s

So, what this means is that the presence of S-ALA reduces the glucose clearing capacity of R-ALA 150% for any value of s and r.

I'lll demonstrate:

Assume a 100% R-ALA product = 100% Glucose capability clearance capacity

100% R-ALA = 100%
98% R-ALA Product = 100% - ((100 - 2) * (1.5)) = 97%
95% R-ALA Product = 100% - ((100 - 5) * (1.5)) = 92.5%
90% R-ALA Product = 100% - ((100- 90) *(1.5)) = 85%
80% R-ALA Product = 100% - ((100- 80) *(1.5)) = 70%
70% R-ALA Product = 100% - ((100- 70) *(1.5)) = 55%
60% R-ALA Product = 100% - ((100- 60) *(1.5)) = 40%
50% R-ALA Product = 100% - ((100- 50) *(1.5)) = 25%

And so on.........

From the glucometric study:

(600mg R-ALA)(36.67 Units Squared) 36.67/76.57 = (1-47.89%) = 52.11% reduction

(1800mg ALA)(40.00 Units Squared) 40.00/76.57 = (1-52.24%) = 47.76% reduction

As you can see the equation is a very good approximation, because a 50/50 racemic mix(50% R-ALA) was found to be 30.6% as effective as a 100% R-ALA one in vivo.

i.e. (600mg/1800mg) * (47.76%/52.11%) = 30.6%
(From the study)

The discrepancy between purities becomes manifest even in the 90% R-ALA product(MANY companies carry this version). Its only 85% as effective as a 100% R-ALA product. Hence the price is obviously going to be lower.

So, you can see how important purity is in R-ALA. AF's is 99.7%. Reason why it works so well, in every single case.

Fonz

 

[macrophage69alpha]

more important though is the plasma insulin reduction, which is severely inhibited by the presence of S. to the point that with a 50/50 racemic mix there is significant increase in plasma insulin

 

[Fonz]

more important though is the plasma insulin reduction, which is severely inhibited by the presence of S. to the point that with a 50/50 racemic mix there is significant increase in plasma insulin

Yes. But I have no desire to put an insulin clamp on my arm for 12hrs every day for 3 months to measure that.

BG is measurable. And from here, with the right equipment and methods can be measured extremely accurately.

Fonz

 

[macrophage69alpha]

Yes. But I have no desire to put an insulin clamp on my arm for 12hrs every day for 3 months to measure that.

quite understandable

 

[DeepZenPill]

Oh man what a great sales pitch

Seriously though, AF carries nothing but the best. Trendsetters in the supplement industry.

 

[kbrkbr]

BAC now carries r-ala, 20 g powder for $16.95. Can't beat that!

I've been using BAC for years and trust them absolutely. They respect their customers with prices that don't gouge, and, at least for me, have never failed to deliver their on thier promises.

 

[Fonz]

BAC now carries r-ala, 20 g powder for $16.95. Can't beat that!

I've been using BAC for years and trust them absolutely. They respect their customers with prices that don't gouge, and, at least for me, have never failed to deliver their on thier promises.

I have bought BAC's and used, it is below 90% purity. That I am sure of.

It tastes WAY TOO acidic for it to be the 98% that they claim.

Maybe 98% at the factory....but it degrades very quickly if improperly processed and stored.

Have you taken a good look at BAC's R-ALA container lately?

I'd wager the stuff is between 80-90% R-ALA when you open it for the first time.

This is one instance where you should not go for quantity.

Fonz

 

[Ulter]

I posted this on the other thread but I would like to make some points here on the analysis of purity of R-ALA.

I have seen two bad assays that people selling R-ALA claim represents the results of their 99% r-ALA.
One is an analysis done buy Dr Patel. No I didn't mispell by, you see he will sell you an analysis in your favor for whatever you pay him for. He claims to be able to determine optical rotation purity by HPLC. This is very curious because he's the only one in the world that can do that. Even Kurt Wuthrich and Richard Ernst can't do it and they have Nobel prizes in chemistry for chemical analysis methods. I know because that’s who we use for ours.
The other assay I see floated is the one that says "Merck standard for r+ lipoic acid" for the standard used for the optical rotation measurement. That standard is +104 degrees. There is a problem with using that standard because it was done in 1954. Since then the equipment used to measure optical rotation has improved, ya think, just a little. The latest and still old measurement was in 1986 by JCS Chemical Communication. It measured +107 degrees for pure R+-ALA. So if someone is using today’s equipment to measure optical rotation accurately but they use +104 degrees as the standard and they determine it’s say the whole +104 degrees then you have skewed purity percentages but it looks good on paper. Because 104+ degrees would be 97% by the 1986 standard. But look further. Glucorell R was measured by the above mentioned lab at +109.27. So in comparison to today’s standard that +104 is really 95%. Which of course means that 5% of it is still S-ALA and THAT’s why it’s 10% less expensive and 50% less effective than Glucorell R.

 

[drrman]

besides all the mumbo jumbo there, i can say from experience the Glucorell is far superior to the other "shit" on the market

 

[SofaGeorge]

BAC now carries r-ala, 20 g powder for $16.95. Can't beat that!

I've been using BAC for years and trust them absolutely. They respect their customers with prices that don't gouge, and, at least for me, have never failed to deliver their on thier promises.

Why do you trust a company that sells inferior ingredients? To me that is a reason to NOT buy from them.

 

[drrman]

just a note here, the glucorell didn't make my piss stink, the other r-ala products made my piss stink....like the original ala did

 

[Deleted member 33117]

DRR, yep I've never used glucorell, but I've noticed other ala's mine smell like horse piss.

 

[kbrkbr]

Why do you trust a company that sells inferior ingredients? To me that is a reason to NOT buy from them.

That's quite an asumption, not to mention quite an accusation, you've made.

Where's your proof that BAC uses "inferior ingredients?"

 

[Fonz]

That's quite an asumption, not to mention quite an accusation, you've made.

Where's your proof that BAC uses "inferior ingredients?"

Have to agree here.

BAC has some great supplements at good prices. I have tried quite a lot of them.
Just b/c their R-ALA is well "suspicious" does not mean that the whole company is BUNK.

Their Green tea for example is excellent. As is their HCA.

Fonz

 

[macrophage69alpha]

the green tea that they sell 40% PE is about 1/6 the cost$ a kilo wholesale of the extract 95%, and yet its being sold at less than twice the cost.

fonz, if you would like will send you a sample of what 50% ecgc is actually supposed to be.. as a mode of comparison..

 

[Fonz]

the green tea that they sell 40% PE is about 1/6 the cost$ a kilo wholesale of the extract 95%, and yet its being sold at less than twice the cost.

fonz, if you would like will send you a sample of what 50% ecgc is actually supposed to be.. as a mode of comparison..

PM.

Fonz

 

[XzRzX]

the green tea that they sell 40% PE is about 1/6 the cost$ a kilo wholesale of the extract 95%, and yet its being sold at less than twice the cost.

fonz, if you would like will send you a sample of what 50% ecgc is actually supposed to be.. as a mode of comparison..

is this a sign of things to come in AF

 

[DeepZenPill]

Well I see a little bashing of BAC here. I understand a few people are trying to make a point that Glucorell-r is the best r-ala supp on the market. I agree. I'm very impressed with AF, and their products always seem to work great. That's what you get from guys who are dedicated to bodybuilding and bodybuilders.

But you can't completely dismiss the fact that BAC sells their shit extremely cheap. Where it may be lacking in quality, you can definitely make up in quantity. When I was using Glucorell, I would only use 200mg at a time for my normal meals. I couldn't afford to use much more. I burned through the shit just with that low dosage. Now I buy through BAC and I'm using 400-600mg per meal and it lasts me. And yes, I do see a better results from the increased dosage.

But AF's is also already capped. If you don't feel like fucking around with capping the stuff, then definitely go with AF, but if you're a poor college student like me, it can get a little pricey if you use it a lot.