why do low / androgenic steroids supress natural test?

[Krazykat]

why do low androgenic steroids supress natural test?

Can someone explain this.

How can using a steroid at a low dose with less androgenic action than one`s own natural test result in inhibition of one`s natural androgen levels?

http://jcem.endojournals.org/cgi/content/full/84/8/2705/F3

For example with the 15 mg of anavar a day example, after three days natural test is inhibited. But why?

Ok so anavar pushes the overall androgen levels with natural test to a level that negative feedback occurs. But why supress the natural test below that of what one would usually have?

I can understand it if you are using loads of test, but with a low dose of anavar why does this happen?

I hope what I wrote makes sense to you guys!

 

[Seth Roberts]

Seeking balance

your body is seeking equilibrium, or balance. When you take a dose of androgen, your body will then adjust test output to arrive at a level that is the same as it was before the dose. You might think, it's only 15 mg but the body sees it differently. If you take an androgen that binds more strongly to the AR, then the body will "see" more androgen and act appropriately. Also, the pharmacokinetics of the dose matter greatly. With anavar taken orally, the body sees a relatively big spike followed by a pretty fast decline. The body will make adjustments continually based on these effects. It will try to keep the level of AR activation level but is not really equipped to deal with external influences.
Seth

 

[Krazykat]

quote sethroberts

"When you take a dose of androgen, your body will then adjust test output to arrive at a level that is the same as it was before the dose."

But this is not the case since in the anavar example the overall androgen level is lower after 3 days with the anavar. If simply trying to keep equilibrium then the body would reduce natural androgen levels so overall levels are what the body would normally produce.

I don`t get it....

 

[Seth Roberts]

Clarification

The body does not necessarily "care" about androgen plasma level. What is happening is trying to adjust the level of AR activation. So, it sees more AR activation with the anavar and adjusts test production downward to reduce the level of AR activation to the pre-dose level (not the plasma androgen level). The actual androgen level may be lower, but the AR activation is still the same because anavar has a stronger affinity for the AR.
Seth