What is the science behind stacking AAS

[Lao Tzu]

I was talking to a very knowledgable poster last night about stacking. he told me about tren and winstrol stacks, how winstrol will upregulate the AR and bind the ER (estrogen) and PR (progesterone) receptors because the trenbolone would push it out of the AR since it has a high affinity for the AR. This stack is very scientific. You get more tren in the AR, less tren in the PR and ER and more AR receptors from this particular stack.

Stacking HGH and/or IGF-1 with AAS makes perfect sense to me too, you combine a drug that makes muscle cells bigger with a drug that builds new muscle cells. I can also understand stacking Insulin (which increases protein uptake) and/or T3 (which increases synthesis)

However in the 4 or so years i've been here there are a few stereotypical stacks i see over and over again.

Test/dbol
test/tren
deca/test

All come to mind. is there a science to these stereotypical stacks or do people just do them for their own reasons? Do people have reasons for most of their stacks?

I thought drugs like eq, anavar or primo could build collagen so i can see the logic in a T3, HGH, Insulin, test and Anavar stack. With those 5 drugs each is helping with protein synthesis in its own way while anavar and HGH help with collagen building. But sometimes it seems like people are just throwing drugs together randomly.

 

[bicepts101]

good post ill bump for some answers

 

[casualbb]

Typically steroids fall into two groups.

Class 1 steroids are very active at the androgen receptor (AR). Thus they will bond to AR's at cell surfaces and within cells to cause growth.

Class 2 steroids bond poorly to the AR, but cause growth through other means.

When you stack a class 1 with a class 2, you cover both bases. The synergy of dose X of one added to dose Y of another causes effects far greater than dose X+Y of one or the other.

Test is kinda both a class 1 AND class 2; it's the basis for comparison. This is how you can run test alone and get great results. However if you stack it with a class 1, results are improved; there's a moderate synergy. Tren and deca are both class 1's, hence the tried-and-true stacks you listed. Dbol is a class 2, I don't know whether or not it has a true synergy with test. Its effect may come simply from the fact that you're adding more androgens, not necessarily because of type.

 

[georgie24]

good post cbb

 

[Triple-G]

Test/dbol
test/tren
deca/test

my reason to do a test + anything stack is libido; any other roid besides test has a potency to decrease libido, esp. deca and tren.

another synergistic compound could be proviron (mesterolone). It is a weak androgen, but binds stronger to SHBG than most other steroids and therefore has a potential to free up more of the steroid you are stacking along proviron.

but i think most users see their stacks working just because they are taking more gear. of course, you get better results if you stack 400mg deca to your 500mg test enanthate cycle, but you would probably get the same with 900mg test. many explain their stacks in scientific terms but there are just no scientific studies on stacking gear for muscle growth. you would need double blind studies of athletes running gear solo and stacked and measure the difference after the course; nobody has done that and it will probably never be done.

 

[The_first_athlete]

I thought Tren fell also in the same category as Test. ??

BTW, whats class is EQ? Primobolan?

 

[jubei]

I like cbb's answer

 

[Cornobbled]

I like to use test for the libido reasons as well. I get good gains on test though so for me it is two fold. All of my stacks have test.

 

[Lao Tzu]

Typically steroids fall into two groups.

Class 1 steroids are very active at the androgen receptor (AR). Thus they will bond to AR's at cell surfaces and within cells to cause growth.

Class 2 steroids bond poorly to the AR, but cause growth through other means.

When you stack a class 1 with a class 2, you cover both bases. The synergy of dose X of one added to dose Y of another causes effects far greater than dose X+Y of one or the other.

Test is kinda both a class 1 AND class 2; it's the basis for comparison. This is how you can run test alone and get great results. However if you stack it with a class 1, results are improved; there's a moderate synergy. Tren and deca are both class 1's, hence the tried-and-true stacks you listed. Dbol is a class 2, I don't know whether or not it has a true synergy with test. Its effect may come simply from the fact that you're adding more androgens, not necessarily because of type.

Interesting. Deca/Dbol is another stereotypical stack, and it would cover both class 1 and 2.

What other avenues for muscle building are there for AAS besides binding to the AR and protein synthesis? I thought all AAS worked the same and all caused DNA transcription since they are all in the same classification of drug.

I can also understand stacking something like anavar, equipoise or primo with a stack due to collagen building.

 

[Mythicalbeing]

CBB is right on the money...very good answer bro.

 

[view]

Bump.