I guess it depends on where the "puffyness" comes from. If it's prolactin, Vitex should help. I don't want to get everyone's hopes up and tell them this is the cure for puffyness, because it's probably not in the majority of the cases of puffyness. But it's so cheap, it wont hurt to try. If femara, arimidex, yohimburn, lipoderm-y, or vitex dont work, then lipo is probably your best bet.