I've only ever seen the protocol recommend running the 1,000 iu per day for as long as you're running the HCG... I'm not sure what effect increased dosage of Vitamin would have otherwise.... I've read that supplementing with large doses of Vitamin E for prolonged periods isn't wise...I've also heard of people doing it and having no problems.... me personally, I only take it while taking HCG... otherwise, a good multi-vitamin is what I'd take