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Well, here are some quotes from the sites mentioned below. Some of the stuff is VERY interesting.
"Vitamin E Makes Prostate Cancer Cells Vulnerable
Vitamin E, a compound suspected of playing a role in preventing prostate cancer, interferes with two proteins that play a central role in the development of the disease, say scientists at the University of Rochester Medical Center who report their findings in the May 28 issue of the Proceedings of the National Academy of Sciences.
[...]
Since vitamin E is a known anti-oxidant that destroys harmful molecules known as free radicals, some scientists have hypothesized that its anti-oxidant properties might help prevent prostate cancer.
But Yeh’s team found that Vitamin E plays an unexpected role in prostate cells. The compound has a dramatic effect on the androgen receptor, a protein in the body that is vital to the growth of prostate cells, including its cancer cells. Researchers found that vitamin E blocks the assembly of the protein, exposing a new vulnerability in a protein that is central to the development of the disease.
The finding gives scientists a new lead to follow when targeting prostate cancer. Currently many of the drugs used to treat prostate cancer either stop the production of testosterone or are "anti-androgens" that prevent testosterone from binding to the androgen receptor, thus stopping the receptor from contributing to cell growth and health. The new research suggests a way to disable the receptor itself. It’s a bit like finding a new way to cut off an engine’s fuel supply: One could stop the flow of gasoline, or one could simply remove or disable the fuel tank.
The scientists also caution that different forms of vitamin E produce different results. The team found that a type known as vitamin E succinate, also known as alpha-tocopheryl succinate, was most effective in halting prostate cancer cells in the laboratory.
"There are several different kinds of vitamin E, and they have different effects. Which type you’re talking about makes a very big difference," says Yeh, whose research project was funded by the National Institutes of Health and the Department of Urology. Yeh has worked closely with Rochester scientist Chawnshang Chang, who discovered the androgen receptor."
The type of vit.E used in the studies is widely available. Doing a quick search on google.com comes up with:
http://store.yahoo.com/beefcakenutrition/twinlab-vitamin-e.html
Probably puritan.com or BAC have even better offers.
But I wonder, if it so effective, why there are no anti-androgen side effects mentioned? Could Vit.E work via some unknow mechanism? Also, if it is effective in disabling androgen receptors - it might work for male pattern baldness.
Anyway, from now on I'll definitely be supplementing Vit.E/daily - it is fat-soluble vitamin so one should watch out for not taking too much.
Here are the links:
* http://www.urmc.rochester.edu/pr/News/vite.html
* http://www.urmc.rochester.edu/path/fac/shuyuan_yeh.htm
And a link with different Vitamin E structures, I've just found.
http://www.uic.edu/classes/phar/pha...tamin cases/vitamin E/Vitamin E Chemistry.htm
"Vitamin E Makes Prostate Cancer Cells Vulnerable
Vitamin E, a compound suspected of playing a role in preventing prostate cancer, interferes with two proteins that play a central role in the development of the disease, say scientists at the University of Rochester Medical Center who report their findings in the May 28 issue of the Proceedings of the National Academy of Sciences.
[...]
Since vitamin E is a known anti-oxidant that destroys harmful molecules known as free radicals, some scientists have hypothesized that its anti-oxidant properties might help prevent prostate cancer.
But Yeh’s team found that Vitamin E plays an unexpected role in prostate cells. The compound has a dramatic effect on the androgen receptor, a protein in the body that is vital to the growth of prostate cells, including its cancer cells. Researchers found that vitamin E blocks the assembly of the protein, exposing a new vulnerability in a protein that is central to the development of the disease.
The finding gives scientists a new lead to follow when targeting prostate cancer. Currently many of the drugs used to treat prostate cancer either stop the production of testosterone or are "anti-androgens" that prevent testosterone from binding to the androgen receptor, thus stopping the receptor from contributing to cell growth and health. The new research suggests a way to disable the receptor itself. It’s a bit like finding a new way to cut off an engine’s fuel supply: One could stop the flow of gasoline, or one could simply remove or disable the fuel tank.
The scientists also caution that different forms of vitamin E produce different results. The team found that a type known as vitamin E succinate, also known as alpha-tocopheryl succinate, was most effective in halting prostate cancer cells in the laboratory.
"There are several different kinds of vitamin E, and they have different effects. Which type you’re talking about makes a very big difference," says Yeh, whose research project was funded by the National Institutes of Health and the Department of Urology. Yeh has worked closely with Rochester scientist Chawnshang Chang, who discovered the androgen receptor."
The type of vit.E used in the studies is widely available. Doing a quick search on google.com comes up with:
http://store.yahoo.com/beefcakenutrition/twinlab-vitamin-e.html
Probably puritan.com or BAC have even better offers.
But I wonder, if it so effective, why there are no anti-androgen side effects mentioned? Could Vit.E work via some unknow mechanism? Also, if it is effective in disabling androgen receptors - it might work for male pattern baldness.
Anyway, from now on I'll definitely be supplementing Vit.E/daily - it is fat-soluble vitamin so one should watch out for not taking too much.
Here are the links:
* http://www.urmc.rochester.edu/pr/News/vite.html
* http://www.urmc.rochester.edu/path/fac/shuyuan_yeh.htm
And a link with different Vitamin E structures, I've just found.
http://www.uic.edu/classes/phar/pha...tamin cases/vitamin E/Vitamin E Chemistry.htm
