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Visual disturbances from clomid
- Thread starter Slyder190
- Start date
Clomid has strong activity at the hypothalamus,which is butted right up next to the optic nerve.It's probably binding slightly on some receptors that are sandwiched in between the two and causing some slight pressure which is interfering with nerve impulse strength to your pupil...Just discontinue it when that starts up,and I would recommend using arimidex in the future as your hormone re-initialization drug.
J Clin Endocrinol Metab 2000 Jul;85(7):2370-7 Related Articles, Books, LinkOut
Estrogen suppression in males: metabolic effects.
Mauras N, O'Brien KO, Klein KO, Hayes V
Nemours Research Programs at the Nemours Children's Clinic, Jacksonville, Florida 32207, USA. [email protected]
We have shown that testosterone (T) deficiency per se is associated with marked catabolic effects on protein, calcium metabolism, and body composition in men independent of changes in GH or insulin-like growth factor I production. It is not clear,,however, whether estrogens have a major role in whole body anabolism in males. We investigated the metabolic effects of selective estrogen suppression in the male using a potent aromatase inhibitor, Arimidex (Anastrozole). First, a dose-response study of 12 males (mean age, 16.1 +/- 0.3 yr) was conducted, and blood withdrawn at baseline and after 10 days of oral Arimidex given as two different doses (either 0.5 or 1 mg) in random order with a 14-day washout in between. A sensitive estradiol (E2) assay showed an approximately 50% decrease in E2 concentrations with either of the two doses; hence, a 1-mg dose was selected for other studies. Subsequently, eight males (aged 15-22 yr; four adults and four late pubertal) had isotopic infusions of [(13)C]leucine and (42)Ca/(44)Ca, indirect calorimetry, dual energy x-ray absorptiometry, isokinetic dynamometry, and growth factors measurements performed before and after 10 weeks of daily doses of Arimidex. Contrary to the effects of T withdrawal, there were no significant changes in body composition (body mass index, fat mass, and fat-free mass) after estrogen suppression or in rates of protein synthesis or degradation; carbohydrate, lipid, or protein oxidation; muscle strength; calcium kinetics; or bone growth factors concentrations. However, E2 concentrations decreased 48% (P = 0.006), with no significant change in mean and peak GH concentrations, but with an 18% decrease in plasma insulin-like growth factor I concentrations. There was a 58% increase in serum T (P = 0.0001), sex hormone-binding globulin did not change, whereas LH and FSH concentrations increased (P < 0.02, both). Serum bone markers, osteocalcin and bone alkaline phosphatase concentrations, and rates of bone calcium deposition and resorption did not change. In conclusion, these data suggest that in the male 1) estrogens do not contribute significantly to the changes in body composition and protein synthesis observed with changing androgen levels; 2) estrogen is a main regulator of the gonadal-pituitary feedback for the gonadotropin axis; and 3) this level of aromatase inhibition does not negatively impact either kinetically measured rates of bone calcium turnover or indirect markers of bone calcium turnover, at least in the short term. Further studies will provide valuable information on whether timed aromatase inhibition can be useful in increasing the height potential of pubertal boys with profound growth retardation without the confounding negative effects of gonadal androgen suppression.
Note the increases in endogenous T production,Leutenizing Hormone,and follicle stimulating hormone.These are all estrogen-suppression related....I want to make it very clear that I gave the above advice to the gentleman because he is having a rare,but serious side effect from his clomid use.In his case,he would be better off switching over to another form of post-cycle treatment,and in this case,arimidex will fit the bill.Do I advocate arimidex-only to everyone as a post-cycle hormonal restorative?Certainly not.But I believe it,COMBINED with clomiphene is the IDEAL post cycle combination for creating an optimal hormonal environment.
HappyScrappy
New member
how long can you continuously use arimidex?
I've been using it between cycles, and then during cycles...
will my body freak out when I stop using it and get high est levels?
am I developing any sort of tolerance to it?
just curious if one needs to cycle the use of arimidex as one would other hormones in order to prevent the body from adjusting and compensating for its presence
I've been using it between cycles, and then during cycles...
will my body freak out when I stop using it and get high est levels?
am I developing any sort of tolerance to it?
just curious if one needs to cycle the use of arimidex as one would other hormones in order to prevent the body from adjusting and compensating for its presence
gorilla_boy
New member
HappyScrappy said:
Bump for HappyScrappy.
gorilla_boy
New member
bump
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