valium increases prolactin?

[perfectspecimen]

is this true?

 

[perfectspecimen]

bump

 

[perfectspecimen]

bump

 

[1Banshee]

From the short amount of reading I just did, it appear the answer is a qualified yes. Qualified the information I can find it somewhat questionable (no studies per say), but most of the info seems to indicate Prolactin does increase with Valium use.

Go here (medline):
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=&DB=PubMed

Then do a search on "valium and prolactin"

What is your take???

 

[monkeyballs]

From what I gathered from the research, it appears that valium actually inhibits prolactin secretion. Check it out.



Clin Neuropharmacol 1998 Mar-Apr;21(2):80-5 Related Articles, Books, LinkOut


Pilot investigation of thyrotropin-releasing hormone-induced thyrotropin and prolactin release in anxious patients treated with diazepam.

Humbert T, Pujalte D, Bottai T, Hue B, Pouget R, Petit P.

Unite de Psychopharmacologie, CHU Hopital La Colombiere, Montpellier, France.

Benzodiazepines have been reported to inhibit thyrotropin (TSH) and prolactin (PRL) secretion in response to stressful and pharmacologic stimuli in experimental animals. The current study investigates basal and thyrotropin-releasing hormone (TRH)-stimulated TSH and PRL release in anxious patients treated with diazepam. Six hospitalized patients having generalized anxiety or adjustment disorder with anxious mood (DSM III-R criteria) were treated during 1 week with diazepam (mean daily dose 33.3 mg). TRH testing was performed comparatively before and after 7 days of diazepam administration (with 250 micrograms protirelin and blood sampling at 15-min intervals over 60 min). Steady-state plasma levels of diazepam and its metabolite nordazepam (desmethyldiazepam) were determined by high-performance liquid chromatography. After 7 days of diazepam treatment, basal plasma levels of TSH and PRL were not affected compared with pretreatment values. Similarly, the time-course of TRH-induced TSH release was not modified by the treatment. By contrast, there was a trend to decrease in the TRH-induced PRL release, and the decrease in the PRL response to TRH on day 7 was significantly correlated with plasma nordazepam concentrations (rs = 0.943, p = 0.02). These preliminary results suggest that benzodiazepines, at therapeutic doses for the treatment of anxiety, may alter TRH-induced PRL release in humans.

PMID: 9579292 [PubMed - indexed for MEDLINE]

 

[perfectspecimen]

bump

 

[CycloneHWT]

i have read if you take enough valium it increases muscle size or something, can someone elaborate?

 

[TooJacked]

Bump. . . I'd like to here some more info

 

[1Banshee]

i have read if you take enough valium it increases muscle size or something, can someone elaborate?

Two different subjects here... I believe you are referring to the cortisol supressing effects of Valium. There is some evidence that valium does suppress cortisol. I would be very careful if considering using valium for a performance enhancing effect. It is as most know very addititive. The effects are addititive due to the extreme half-life of the drug. Meaning after a few days of using it just at night for sleep you will begin to notice more and more of its calming effect during the day as the drug builds in your system.
If you use it for sleep be aware that nearly all of the Benzo (Valium, Xanax, etc) class drugs clobber stage 3 and 4 of sleep. 3 and 4 are the times when our bodies do most of it solid recovery... So it is kind of a trade off, yea you will suppress some cortisol, but at the cost of stage 3 and 4 of sleep...

 

[perfectspecimen]

is l-tryptophan good for stage 3 and 4 sleep

 

[1Banshee]

is l-tryptophan good for stage 3 and 4 sleep

I am just beginning to look into that question. Here is the first article, I came upon. There are many many more, just gotta find time to look at them.
Take a look at this:

Electroencephalogr Clin Neurophysiol 1979 Nov;47(5):539-45 Related Articles, Books, LinkOut


L-tryptophan and sleep in healthy man.

Nicholson AN, Stone BM.

The effect of L-tryptophan on night-time and day-time sleep (from 14.00 h) sleep was studied in six healthy males aged between 20 and 30 years. The doses used in the night-time studies were 2, 4 and 6 g, and in the day-time studies 1, 2 and 4 g. It was not possible to establish an effect of L-tryptophan compared with placebo on night-time sleep, but analysis of the sleep measures with 4 g compared with placebo and the other doses of L-tryptophan considered together suggested reduced awakenings, increased stage 3 and an increased percentage of REM sleep. With 4 g L-tryptophan there was an increase in the duration of stage 3 of day-time sleep compared with placebo. The studies provide marginal evidence that REM sleep may be modified by L-tryptophan in man, though the evidence is somewhat stronger that SWS may be increased. The effect on REM sleep may involve circadian mechanisms. The hypnotic activity of L-tryptophan per se is limited and uncertain.