SAN Nutrition makes it.
These new creatines are a joke - have you seen the way it is advertised, hardly inspires confidence. - "With the birth of Fuel Injection V12, faster gains in muscle mass, strength and endurance, become now a reality" lol!
It contains less creatine 3g, and costs more! What's more, it contains "creatine tri-malate" - this is a fallacy, as only 2 malates can bond to a creatine molecule due to their electrical charge (+ 2 charge of the malate) IT IS DI-CREATINE MALATE!. You would honestly be beter off going to a wine merchant, and getting some plain 'ol malic acid - it can be bought for a very cheap price, because the wine industry uses it as a form of preservative. Malate is an intermediatory in the krebs cycle (ATP) - WHY SHOULD DI-MALATE BE ANY BETTER THAN MALATE?
The quantities of the ingredients are so low (mostly 1g), that even if they did anything, you would need a much higher doseage - 1g of AKG lol!, 1g of taurine - lol!
Glycocyamine is included much like with Maximuscle creatine, with the addition of TMG (this is something maximuscle should have done, as tmg keeps the dangerous elevated homocysteine levels arising from glycocyamine - GAA supplementation)- By allowing creatine synthesis to proceed simultaneously with GAA administration , it consumes serum methionine and elevates plasma homocysteine levels (naughty Maximuscle!)
In fact, some experts have estimated that endogenous creatine synthesis is responsible for producing 75% of the total homocysteine present in humans.
Clinical research has shown that elevated serum homocysteine levels are strongly indicative of the chances of developing Coronary heart disease in later life. In fact, just a small (5 microMolar) increase in serum homocysteine levels increases the chances of developing CHD by 60% in men and an incredible 80% in women.
Elevated plasma homocystein levels are also associated with the development of Alzeimers disease, hypertension, neurological defects, dementia, loss of cognitive function and renal/liver disease
When the dietary intake of methionine is insufficient to meet the body's needs, methionine can be obtained by modifying another molecule known as homocysteine. In essence, homocysteine is a methionine molecule lacking its signature methyl group. GAA plus a methyl group (previously synthesised from methionine as S-adenosylmethionine ,SAM, the body's "universal donor") creates creatine.
As a methyl donor, betaine (trimethylglycine) participates in the methionine cycle—primarily in the human liver and kidneys. Inadequate dietary intake of methyl groups leads to hypomethylation in many important pathways, including 1) disturbed hepatic protein (methionine) metabolism as determined by elevated plasma homocysteine concentrations and decreased S-adenosylmethionine concentrations, and 2) inadequate hepatic fat metabolism, which leads to steatosis (fatty accumulation) and subsequent plasma dyslipidemia
There are 2 pathways for homocysteine to be removed: either the re-methylation regenerates methionine , or the trans-sulpherisation pathway degrades homocysteine into cysteine and taurine.
Trimethylglycine can assist in the generation of modest increases of plasma serine and simultaneous increases of plasma cysteine levels . Levels of serine are depressed in some individuals with extcess homocysteine. They are treated with folic acid, cobalamin, vit B6 and pyridoxal-5-phosphate(all in the MRP as vitamins, and a lot less costly than TMG!- excluding the 3-phosphate) Serine is needed so hat folic acid can be converted to its active form. It is also used to shuttle methyl groups between the cytosol and mitachondria, coverting folic acid into its active form. Additionally, it acts as a co factor for methionine/ homocysteine metabolism (I'm sure whey protein/a high protein diet provides more than enough serine for this purpose)
One possible benefit of betain supplementation with TMG is through cell hydration. TMG is an osmolyte that increases the water retention of cells, replaces inorganic salts, and protects intracellular enzymes against osmotically induced or temperature-induced inactivation. betaine is not catabolized, it is used as an organic osmolyte. The regulation of cellular hydration state, and therefore cell volume, is important for maintenance of cell function. Sensitive metabolic pathways include protein turnover, amino acid and ammonia metabolism, carbohydrate and fatty acid metabolism, plasma membrane transport, bile excretion, pH control, and gene _expression. Cells adapt to external osmotic stress by accumulating low-molecular-weight inorganic ions (eg, sodium, potassium, and chloride) and organic osmolytes (eg, methylated amines, certain amino acids, and sugar alcohols). However, the increase in intracellular concentrations of inorganic ions is limited because of their destabilizing effect on protein structure and enzyme function
In various organisms and animal tissues. Mechanistic studies showed that there is little or no binding of betaine to protein surfaces, allowing cells to control the surface tension of water without affecting the ionic strength of the environment, eg, stabilization of lipase.
Betaine is the most effective osmolyte studied for hydration of albumin , forming almost a complete monolayer of water around the protein, and betaine can maintain hemoglobin solvation..
It is rapidly absorbed and utilized as an osmolyte and source of methyl groups and thereby helps to reduce LDL, maintain liver, heart, and kidney health.
Great u think, I can take creatine and increase creatine synthesis by providing the tools that the body needs to do this - wrong studies show that creatine uptake is impaired by the supplementation of GAA (so u don't get any additional benefit)
As 4 the amount of creatine per serving, it is pitiful (there have been no studies showing any extra benefit to this type of creatine)
More bad news: a study found that dietary intake of betaine ranges from an average of 1 g/d to a high of 2.5 g/d (for a diet high in whole wheat and seafood) - V12 has 1.5g. You can easily achive super high levels of betain if you eat a lot of fish, wheat or spinach amonst other foods ( wheat bran has 1339 mg per 100g, spinach 600-635mg/100g)- the 1.5g doesn't seem a great deal.
so the jury is still out on betain, tmg or trimethylglycine or what ever u want to call it. It certainly won't work in the way it is marketed to do.
Dietary methionine intake is necessary for overall good health- but I am sure that you would easily get enough from consuming protein powder or a protein rich diet (V12 has no methionine- seems strange when the purpose is to decrease homocysteine and provide greater synthesis of methionine so that SAM can donate methyl groups to GAA)
I haven't researched N-Acetyl-Glutamine yet, but seeing as v12 only has 1g of this, I can't see it having a superior effect over glutamine. In addition there is 1g of "nito arginine" or arginine alphaketoglutarate ) - which is a component of OKG . There is only 3g of the suposably improved creatine "tri malate" - only "di" possible - this is considerable less than the usual 5g recommendation - do u really think that this is gonna be more than 66% more absorpable!?
The advertising is a load of b.s., as too the name v-12 turbo like a powerful engine, geddit!
I'm not meaning to plug my own products, but I am developing a range, and am debating whether to develop the creatine formula. I did a comparison with Maximuscle 8000ES - ontop of the info I posted above, there are serious no-brainers in Maximuscle's formula - thought I should post it - just shows you that these so called top companies don't do proper research:
MAXIMUSCLE 8000ES
• Creatine Monohydrate 5g
• L-Glutamine 5g
• Glycine 1g
• GAA 1g
• Potassium Bicarbonate 500mg
• Sodium Bicarbonate 500mg
• Albion Magnesium chelate 50mg
• D-pinitol 28mg
• Bioperine 5mg
ATP EXPLOSION
CREATINE MAGNESIUM CHELATE 10g
ALPHA LIPOIC ACID (R-ENAMETOR) 600mg
RIBOSE 10g
D-PINITOL 500mg
GLUCOSE 18g
TAURINE 5g
GLUTAMINE 5g
ADDED BENEFIT OF THE tribasic sodium phospahate , other insulin mimickers, and OKG (extra glutamine source) in the whey/meal formulae. Hopefully the loading of phosphates will facilitate a greater uptake and utilization of creatine , providing a large amount of substrates (need 90g of sodium bicarb to do the same job)
p.s creatine magnesium chelate is superior to monohydrate and magnesium chelate in separate forms (increased absorption through higher pH and no stomach upsets)
Maximuscle has arginine and glycine (GAA) for increased hydration , I found a study showing that the perfusion of very low concentrations of arginine stimulated sodium and water absorption, but higher concentrations had the reverse effect. If 500mg is arginine, what is the point of it being in – can get this from the protein powder you take with it. It also seems that more is worse.
The glycine in the formula (1g),is included for the same effect but a study reported this - It is concluded that excess glycine in relation to sodium in an ORS may lead to osmotic diarrhoea, and a high amount of absorbed glycine may result in osmotic diuresis with poor net rehydration. Altogether, the present study failed to find any improvement ('Super-ORS') by addition of glycine to an ORS containing 60 mmol/l of sodium.
- Glycerol is “the daddy” for hyperhydration – but u need 90g!- and to take lots of water.
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