I'm using 3ml of PGF a day, and from my first shot to now, I still haven't had any of the major sides people speak of.... I've had the localized pain, and when I do my chest, I can watch my nipples go from normal size to the smallest, hardest things I've ever seen..... Not to mention that if you touch them it's instantaneous pain. I have never had the shits, have had the chest constricting, but nothing else...... I'm thinking of upping the dose to 4ml a day(I basically hit everywhere, rotate 4 spots on my chest, some on the love handles).... Maybe I am just lucky.....lol