Please Scroll Down to See Forums Below 
There is more to dihydrotestosterone (DHT) than just side effects.
DHT is a far more potent androgen than testosterone. It's binding ability to the androgen receptor is approximately 2.5 to 5 times greater. In skeletal muscle, Testosterone is the primary androgen. There is minimal to no conenctrations of 5AR in skeletal muscle which translates as minimal to no formation of DHT. Although DHT does exert limited anabolic effects in skeletal muscle, it is rapidly deactivated by the 3alpha hydroxysteroid reductase enzyme (3aHSD).
The impact of DHT on strength is more profound due to it's impact on the Central Nervous System (CNS). Various parts of the brain are saturated in 5AR. Basically, DHT amplifies the androgenic signal of testosterone and therefore increases neurological efficiency and resistance to physical and pyschological stress, all of which are directly related to strength.
DHT is primarly an androgen but it does exert an indirect anabolic effect. In the human body only a very small percentage of testosterone is free at any given time to interact with cellular receptor sites. This is because the vast majority (98%) will form temporary complexes with the plasma binding proteins Sex Hormone Binding Globulin (SHBG) and albumin, which prevent the hormone from exerting activity in the body. It is here that dihydrotestosterone differs from testosterone in another important way, in that it binds several times more avidly to SHBG in comparison. As the level of DHT rises in the body, so would the amount of free testosterone, as the former hormone will be out competing the latter for binding to SHGB. This would occur in a dose dependent manner, the greater the ratio of DHT to testosterone the better the effect achieved. The down fall is that DHT related side effects would also become more prevalant.
Androgens and estrogens both play important roles in mediating the disposition of body fat and lean muscle mass. Their respective roles however appear to be very different. While androgens are the primary hormones responsible for muscle growth, they also seem to play a part in promoting fat loss. The specific mechanism involved may be the support of catecholamine-induced lipolysis, caused by the androgen increasing the number of beta adrenergic receptors (the primary triggers for fat mobilization) on the membrane surface of fat cells. Since DHT cannot be aromatized, its activity in the body is purely androgenic. As a result a notable shift in androgen/estrogen ratio would result with use, which can prove to be very beneficial in supporting a fat burning metabolism. As the ratio of androgenic to estrogenic action rises, so should the level of fat loss achieved.
When considering optimal functiong weight in conjuntion with strength and performance, DHT does have it's place in an athletes arsenal. It's secondary anabolic and lypolytic properties do exsist but are far less pround than it's direct adrogenic interaction with the CNS. It is for these reasons that many athletes and bodybuilders (precontest) will use these non aromatizable compounds such as stanozolol, methenolone, oxandrolone, mesterolone and drostanolone. It is for these same reasons that athletes and bodybuilders will limit and/or minimize their usage (dosage and duration) of these compounds due to DHT's profound side effects such as adrogenic alopecia, acne and prostatic hypertrophy.
Jenetic
DHT is a far more potent androgen than testosterone. It's binding ability to the androgen receptor is approximately 2.5 to 5 times greater. In skeletal muscle, Testosterone is the primary androgen. There is minimal to no conenctrations of 5AR in skeletal muscle which translates as minimal to no formation of DHT. Although DHT does exert limited anabolic effects in skeletal muscle, it is rapidly deactivated by the 3alpha hydroxysteroid reductase enzyme (3aHSD).
The impact of DHT on strength is more profound due to it's impact on the Central Nervous System (CNS). Various parts of the brain are saturated in 5AR. Basically, DHT amplifies the androgenic signal of testosterone and therefore increases neurological efficiency and resistance to physical and pyschological stress, all of which are directly related to strength.
DHT is primarly an androgen but it does exert an indirect anabolic effect. In the human body only a very small percentage of testosterone is free at any given time to interact with cellular receptor sites. This is because the vast majority (98%) will form temporary complexes with the plasma binding proteins Sex Hormone Binding Globulin (SHBG) and albumin, which prevent the hormone from exerting activity in the body. It is here that dihydrotestosterone differs from testosterone in another important way, in that it binds several times more avidly to SHBG in comparison. As the level of DHT rises in the body, so would the amount of free testosterone, as the former hormone will be out competing the latter for binding to SHGB. This would occur in a dose dependent manner, the greater the ratio of DHT to testosterone the better the effect achieved. The down fall is that DHT related side effects would also become more prevalant.
Androgens and estrogens both play important roles in mediating the disposition of body fat and lean muscle mass. Their respective roles however appear to be very different. While androgens are the primary hormones responsible for muscle growth, they also seem to play a part in promoting fat loss. The specific mechanism involved may be the support of catecholamine-induced lipolysis, caused by the androgen increasing the number of beta adrenergic receptors (the primary triggers for fat mobilization) on the membrane surface of fat cells. Since DHT cannot be aromatized, its activity in the body is purely androgenic. As a result a notable shift in androgen/estrogen ratio would result with use, which can prove to be very beneficial in supporting a fat burning metabolism. As the ratio of androgenic to estrogenic action rises, so should the level of fat loss achieved.
When considering optimal functiong weight in conjuntion with strength and performance, DHT does have it's place in an athletes arsenal. It's secondary anabolic and lypolytic properties do exsist but are far less pround than it's direct adrogenic interaction with the CNS. It is for these reasons that many athletes and bodybuilders (precontest) will use these non aromatizable compounds such as stanozolol, methenolone, oxandrolone, mesterolone and drostanolone. It is for these same reasons that athletes and bodybuilders will limit and/or minimize their usage (dosage and duration) of these compounds due to DHT's profound side effects such as adrogenic alopecia, acne and prostatic hypertrophy.
Jenetic
Last edited:
