The future for glucose disposal agents......

[Fonz]

1: Antioxid Redox Signal 1999 Winter;1(4):523-35 Related Articles, Books, LinkOut


Metabolic effects of gamma-linolenic acid-alpha-lipoic acid conjugate in streptozotocin diabetic rats.

Khamaisi M, Rudich A, Beeri I, Pessler D, Friger M, Gavrilov V, Tritschler H, Bashan N.

Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Data suggesting the involvement of increased oxidative stress in the pathophysiology of diabetes has raised interest in the potential therapeutic benefit of antioxidants. Although beneficial metabolic effects of antioxidant supplementation have been suggested, an antioxidant mode of action, particularly in skeletal muscle, has not been documented. In the present study, we evaluate the metabolic effects of a gamma-linolenic acid-alpha-lipoic acid conjugate (GLA-LA) in streptozotocin-induced diabetic rats, and assess its potential mode of action by comparing its effects with equimolar administration of LA and GLA alone. Ten days of oral supplementation of 20 mg/kg body weight GLA-LA, but not LA or GLA alone, caused a mild reduction in fasting blood glucose concentration as compared with vehicle-treated diabetic rats (375 +/- 11 vs. 416 +/- 16 mg/dl, p = 0.03), with no change in fasting plasma insulin levels. A peripheral insulin-sensitizing effect could be observed with GLA-LA, LA, and GLA treatments, as demonstrated by a significant (p < 0.04) 23%, 13%, and 10% reduction, respectively, in the area under the glucose curve following an intravenous insulin tolerance test. This effect was associated with a 67% and 50% increase in GLUT4 protein content in the membranes of gastrocnemius muscle of GLA-LA and LA-treated animals, respectively; however, no change was observed with GLA treatment alone. Interestingly, both GLA-LA and LA treatments corrected a diabetes-related decrease in the gastrocnemius muscle low-molecular-weight reduced thiols content. These data demonstrate insulin-sensitizing properties of the GLA-LA conjugate by distinct mechanisms attributable to each of its components, which are associated with antioxidant effects.

PMID: 11233149 [PubMed - indexed for MEDLINE]

Finally found this little bugger.......

20mg/Kg assuming the person is 100Kg.

Thats 2000mg of the combo.

GLA works at approx. 1200mg, so ALA is 800mg.
However, remember THIS IS A CONJUGATE!!

NOT, both taken together in different pills.

Lets look at the ALA-GLA, ALA and GLA results:

Its 23%---------13%-------10%

Can we say...WOW!!!

GLA-ALA demolishes ALA in terms of reducing your
your bodies insulin-glucose response to food.
This means that you will store less fat and use
more glucose for fuel.

And, to top it of.....

In response top ALA-GLA and ALA's ability to
increase the Glut-4 concentrations on the
out-side of the cell, the results are still
quite noteworthy.

67% ALA-GLA vs 50% ALA alone.

So, in conclusion, it seems that GLA has the ability to
modulate insulin secretion while GLA amplifies
ALA's glut-4 increasing effects.

Its really to bad nobody has ever picked up on this
because it'll sell like hot-cakes.

Fonz

 

[Fonz]

Time to un-load my MASSIVE archive on ALA.......LOL

This one is quite interesting.......

1: Br J Nutr 1999 Dec;82(6):497-503 Related Articles, Books, LinkOut


Involvement of lipoic acid in plasma metabolites, hepatic oxygen consumption, and metabolic response to a beta-agonist in broiler chickens.

Hamano Y, Sugawara S, Kamota Y, Nagai E.

Department of Animal Science, Akita Prefectural College of Agriculture, Ohgata, Japan. [email protected]

The present study was conducted to determine the role of alpha-lipoic acid (LA) in plasma metabolites, hepatic O2 consumption, and beta-adrenergic response in broilers. In Expt 1, 12-d-old female broiler chicks were divided into three dietary groups and fed on diets with or without LA (5 or 50 mg/kg) until 4 or 6 weeks of age, as a 2 x 3 factorial arrangement. The dietary LA had no effect on growth rates (body weight, abdominal fat, breast muscle, and liver). The higher level of LA increased plasma non-esterified fatty acid and decreased plasma triacylglycerol concentrations only at 6 weeks of age. A 42% increase in hepatic respiration was observed in the 4-week-old chickens given 50 mg LA/kg diet. In Expt 2, 3-d-old female broiler chicks were treated with or without dietary LA at 50 mg/kg. At 30 and 31 d old, isoproterenol (2 mg/kg body weight per h) was continuously infused into a wing vein for 2 h, and changes in plasma glucose, triacylglycerol, and non-esterified fatty acid concentrations were analysed. Isoproterenol increased plasma glucose over basal levels maximally at 60 min. Furthermore, the glucose increase in the LA-treated chickens was 35% greater than that of the controls at this time. Plasma non-esterified fatty acid and triacylglycerol concentrations were decreased by the isoproterenol infusion, regardless of LA administration. Therefore, the present study suggests that dietary LA has repartitioning effects on energy metabolism in chickens (although this depends on age-related metabolic state) and is a possible facilitator in the beta-adrenergic response of plasma glucose to a beta-agonist.

PMID: 10690165 [PubMed - indexed for MEDLINE]

ALA increases hepatic respiration AND

It makes BETA-AGONIST DRUGS(i.e. Clen/ephedrine etc..)
MORE EFFICIENT!!!!

The fact that ALA is a nutrient re-partitioning agent goes
without saying.

Fonz

 

[DaMan]

The fact that ALA is a nutrient re-partitioning agent goes
without saying.

Fonz

What exactly does that mean anyway? I've heard that term thrown around a bit...

Good info, btw.

 

[b22md]

how hard is this to obtain, and more importantly is it legal?


BTW Fonz check your email

 

[DrJMW]

Glucophage or Metformin is the drug of choice for glucose disposal agents. it's cheap, it works, and it will be around a long time--as we age, most of us develop some insulin resistance.

 

[rugger]

What exactly does that mean anyway? I've heard that term thrown around a bit...

Good info, btw.

It tells nutrients where they are supposed to go...like a traffic cop for aminos, sugars, fats, etc.

 

[DrJMW]

Rugger is correct. In obese people and insulin resistant folks, adipose tissue wins out over muscle every day. Glucophage helps re-partition the nutrients away from the fat cells and into the muscle and other peripheral tissues.

 

[barnidge]

Are there certain times of the day that Glucophage could best be utilized? What dose?

 

[Riker29]

Fonz is by FAR one of my favorite experts. He bases what he says on a good combination of tests and research and also REAL WORLD EXPERINCE. He also has an open mind and will accept input, and handles questions without turning into a pissy little boy when someone challenges him on what he says (unlike some people ...).

Question Fonz:

OK, in English (LOL), what does this mean? Sound like you are say that instead of just ALA alone .... that ALA WITh GLA will be more effctive?

But what is GLA?

And how did Glucophage get into this discussion anyhow?

 

[ultragainz]