This might help
Borrowed from AE:
Clonidine Hydrochloride (Catapres)
Description: Clonidine is an oral and topical anti-hypertensive agent but is also used to treat cancer pain. This drug was synthesized in the early 1960s for use as a nasal decongestant but clonidine was found to produce hypotension, bradycardia, and sedation at remarkably low doses. Clonidine is used mainly in the treatment of hypertension, but has been used successfully in a variety of other conditions including opiate withdrawal, nicotine withdrawal, vascular headaches, diabetic diarrhea, glaucoma, ulcerative colitis, Gilles de la Tourette's syndrome, and symptoms associated with menopause. Clonidine is available as an oral preparation, a transdermal system, and an injection for epidural use. Clonidine has been used in the United States since FDA approval was given in 1974. The epidural injection (Duraclon®) was approved in early 1997. (taken from online drug reference but edited by author)
Pharmacokinetics: Clonidine is administered epidurally, orally and via transdermal patch. Clonidine is rapidly and completely absorbed following oral administration; bioavailability approaches 100%. Blood pressure begins to decrease within 30—60 minutes, with maximal hypotensive effects occurring in 2-4 hours. Therapeutic plasma concentrations of clonidine are attained 2—3 days after transdermal application. {taken from online drug reference)
Bodybuilding: Today this drug is prescribed to treat high blood pressure but is sometimes used to treat depression or other mood disorders. This drug has many uses for the bodybuilder. First, anabolic steroids (and the accompanying weight gain) can cause high blood pressure. Some drugs, like oxymethelone, are notorious for this side effect. In addition, when you start to weigh over 250 pounds, it is reasonable to assume your blood pressure will increase, even with a moderate cardiovascular training regime. While initially this increase in blood pressure may not be noticeable or unpleasant, it can quickly get out of hand. Jason Meuller can tell you all about the joys of high blood pressure from anabolic steroids and weight gain. So, using catapres would help lower your blood pressure.
A second property of catapres is that is a growth hormone booster. The literature claims that catapres can cause ridiculous increases in growth hormone levels. In practice, it does not seem that catapres has any noticeable anabolic or regenerative effect. This may be because high dosages of the drug (30mg per day) are hard to tolerate due to drowsiness.
I have experimented with Catapres, for 2 weeks, I took 20mg before bed. While I did sleep better, I found that I got extremely dizzy and almost a little “high”; certainly I was somewhat disorientated. After 2 weeks, I had not noticed much except a slight reduction in body-fat. However my blood pressure was ridiculously low, I forget the exact levels but suffice it to say that I was impressed with the anti-hypertensive effects of the drug.
My conclusion was that for a healthy male athlete, the growth-hormone increase from the drug was not significant. Therefore, while I would not consider this drug a replacement for GH I would recommend its use to combat steroid-induced high blood pressure.
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