Not really for Cyp... since it isnt diminished halfway yet, you will keep spiking higher and higher each week. You will have more gradual slopes with Cyp 1x per week.
With Enan, yes you will have more stable levels at 2x - but I stick with 1x/wk for convenience.
At HRT clinics, I believe the set regimen is a shot once a week or bi weekly (not that theyre always correct, just something to think about).