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jpl26
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This new study shows how T2 increases BAT thermogenesis independently of T3 levels, and can be used as an additive to a T3 cycle, to stimulate fat loss even further, through BAT thermogenesis.
1: J Clin Invest. 2001 Nov;108(9):1379-85. Related Articles, Links
The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue.
de Jesus LA, Carvalho SD, Ribeiro MO, Schneider M, Kim SW, Harney JW, Larsen PR, Bianco AC.
Thyroid Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Type 2 iodothyronine deiodinase (D2) is a selenoenzyme, the product of the recently cloned cAMP-dependent Dio2 gene, which increases 10- to 50-fold during cold stress only in brown adipose tissue (BAT). Here we report that despite a normal plasma 3,5,3'-triiodothyronine (T3) concentration, cold-exposed mice with targeted disruption of the Dio2 gene (Dio2(-/-)) become hypothermic due to impaired BAT thermogenesis and survive by compensatory shivering with consequent acute weight loss. This occurs despite normal basal mitochondrial uncoupling protein 1 (UCP1) concentration. In Dio2(-/-) brown adipocytes, the acute norepinephrine-, CL316,243-, or forskolin-induced increases in lipolysis, UCP1 mRNA, and O(2) consumption are all reduced due to impaired cAMP generation. These hypothyroid-like abnormalities are completely reversed by a single injection of T3 14 hours earlier. Recent studies suggest that UCP1 is primarily dependent on thyroid hormone receptor beta (TR beta) while the normal sympathetic response of brown adipocytes requires TR alpha. Intracellularly generated T3 may be required to saturate the TR alpha, which has an approximately fourfold lower T3-binding affinity than does TR beta. Thus, D2 is an essential component in the thyroid-sympathetic synergism required for thermal homeostasis in small mammals.
To sum it up.
UCP1 is activated by a thyroid hormone receptor called (TR Beta), which is chiefly responsible for T3's uncoupling properties.
However, the symathetic response for BAT comes from another thyroid hormone receptor (TR Alpha)......which is activated by T2.
Now while T3 is proteolytic in nature, T2 is most definately not. It activates Brown Adipose tissue thermogenesis.
So, what one could do, when dieting, and to overcome the lowered T3 levels, is to add 25-50mcg T3 and roughly 400mcg T2. The benefits of this combination is less proteolytic catabolism than a normal T3 cycle, and greater BAT thermogenesis, and increased BMR in general. With strong AAS like Trenbolone, you could increase the T3 dose to 100-150mcg, and add the T2 at 400mcg for a super-synergistic effect, but that's for more advanced users.
Note: The addition of Green Tea, would also potentiate this stack, as it's ECGC's activate BAT as well. 900-1200mg's day of the ECGC's would be sufficient.
T2 has not really received a lot of reviews, most likely due to the fact that most people use brands that sell T2 in pill form. It is more than likely that these pills are way/severely underdosed. If you can, go with a reputable source that has it in liquid form. IMO, T2 is definately a good adjunct to a T3+AAS cycle for fat loss.
1: J Clin Invest. 2001 Nov;108(9):1379-85. Related Articles, Links
The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue.
de Jesus LA, Carvalho SD, Ribeiro MO, Schneider M, Kim SW, Harney JW, Larsen PR, Bianco AC.
Thyroid Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Type 2 iodothyronine deiodinase (D2) is a selenoenzyme, the product of the recently cloned cAMP-dependent Dio2 gene, which increases 10- to 50-fold during cold stress only in brown adipose tissue (BAT). Here we report that despite a normal plasma 3,5,3'-triiodothyronine (T3) concentration, cold-exposed mice with targeted disruption of the Dio2 gene (Dio2(-/-)) become hypothermic due to impaired BAT thermogenesis and survive by compensatory shivering with consequent acute weight loss. This occurs despite normal basal mitochondrial uncoupling protein 1 (UCP1) concentration. In Dio2(-/-) brown adipocytes, the acute norepinephrine-, CL316,243-, or forskolin-induced increases in lipolysis, UCP1 mRNA, and O(2) consumption are all reduced due to impaired cAMP generation. These hypothyroid-like abnormalities are completely reversed by a single injection of T3 14 hours earlier. Recent studies suggest that UCP1 is primarily dependent on thyroid hormone receptor beta (TR beta) while the normal sympathetic response of brown adipocytes requires TR alpha. Intracellularly generated T3 may be required to saturate the TR alpha, which has an approximately fourfold lower T3-binding affinity than does TR beta. Thus, D2 is an essential component in the thyroid-sympathetic synergism required for thermal homeostasis in small mammals.
To sum it up.
UCP1 is activated by a thyroid hormone receptor called (TR Beta), which is chiefly responsible for T3's uncoupling properties.
However, the symathetic response for BAT comes from another thyroid hormone receptor (TR Alpha)......which is activated by T2.
Now while T3 is proteolytic in nature, T2 is most definately not. It activates Brown Adipose tissue thermogenesis.
So, what one could do, when dieting, and to overcome the lowered T3 levels, is to add 25-50mcg T3 and roughly 400mcg T2. The benefits of this combination is less proteolytic catabolism than a normal T3 cycle, and greater BAT thermogenesis, and increased BMR in general. With strong AAS like Trenbolone, you could increase the T3 dose to 100-150mcg, and add the T2 at 400mcg for a super-synergistic effect, but that's for more advanced users.
Note: The addition of Green Tea, would also potentiate this stack, as it's ECGC's activate BAT as well. 900-1200mg's day of the ECGC's would be sufficient.
T2 has not really received a lot of reviews, most likely due to the fact that most people use brands that sell T2 in pill form. It is more than likely that these pills are way/severely underdosed. If you can, go with a reputable source that has it in liquid form. IMO, T2 is definately a good adjunct to a T3+AAS cycle for fat loss.
We lose all most all ours (Except for a tad around organs) after we're children.
