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yatesolympia
New member
Just posting this because sombody was running there mouth on the board the other day stating GHB does not increase Gh lvl's , has no science behind it, and is purely recreational. Well heres your science..... Enjoy 
Known here in Europe as Gamma-OH, and in the US and Canada as GHB, gamma-hydroxybutyrate is a novel compound that increases sociability and may function as an antidepressant. Its sale was banned in the US in 1990, in spite of the fact that there is no scientific evidence that it posed any health risk when used responsibly.
GHB, or gamma-hydroxybutyrate, is a normal component of mammalian metabolism. Found naturally in every cell in the human body, it is therefore considered a nutrient. In the brain, the highest amounts are found in the hypothalamus and basal ganglia. GHB is found in greater concentrations in kidney, heart, skeletal muscles, and fat tissues. Some scientists believe it to be a neurotransmitter. It is both a metabolite and precursor of the inhibitory neurotransmitter GABA (gamma-aminobutyric acid, or gamma-aminobutyrate), another nutrient to which it bears a close structural relationship. GHB, however, does not act directly on GABA receptor sites.
GHB was first synthesized about thirty years ago by a French researcher Dr. H. Laborit, who was interested in exploring the effects of GABA in the brain. Laborit synthesized GHB, which substitutes a hydroxy group for an amino group because little or no GABA crosses the blood-brain barrier. This difference allows GHB to cross the blood brain barrier where some of it is metabolized into GABA.
It turns out that Laborit found that GHB exhibited a range of effects beyond those expected from GABA. Over the following years, numerous researchers have extensively studied GHB's effects. It is has come to be used in Europe as a general anesthetic, a treatment for insomnia and narcolepsy, an aid to childbirth, a treatment for alcoholism and alcohol withdrawal syndrome, and for many other uses. In the United States, Canada, Japan and Australia, GHB is used by members of the underground rave culture as a safe alternative to alcohol or ecstasy. Before it was banned, bodybuilders in the United States used GHB to increased growth hormone levels.
GHB actually stimulates pituitary growth hormone (GH) release. One methodologically rigorous Japanese study reported nine-times and sixteen-times increases in growth hormone 30 and 60 minutes respectively after intravenous administration of 2.5 grams of GHB in six healthy men between the ages of twenty-five and forty. GH levels were still seven-times higher at 120 minutes.
The mechanism by which GHB stimulates growth-hormone release is not known. Dopamine activity in the hypothalamus is known to stimulate pituitary release of growth hormone, but GHB inhibits dopamine release at the same time that it stimulates GH release. This suggests that GHB's GH-releasing effect take place through an entirely different mechanism.
GHB is normally available as either the sodium salt (Na-GHB) or the potassium salt (K- GHB) of gamma-hydroxybutyrate. GHB could theoretically be produced in other salt forms but it has not been seen available. Na-GHB is about 10% - 15% stronger than K-GHB by weight so dosage has to be adjusted accordingly.
Professionally produced pharmaceutical-grade GHB will almost always be a white crystalline powder (although there are some exceptions to this in pharmaceutical preparations such as Alcover and Pro-K.) The synthesis of GHB is relatively simple hence the proliferation of some companies selling kits to make GHB and amateur attempts by underground chemists to produce it. GHB produced at home will generally be in a liquid form. I will outline how to make GHB later on in this essay.
While some people consider making their own GH, and this is sometimes necessary in countries like the United States where unscientific political and economic forces cause pharmaceutical GHB to disappear from the market, it's not recommended. It is not advisable to try making GHB yourself if you have no experience with handling chemicals. It is best to try to obtain pharmaceutical GHB from a reputable company. Because the majority of us live in countries where GHB is illegal, such companies are rare. One, Biogenesis Laboratories
Known here in Europe as Gamma-OH, and in the US and Canada as GHB, gamma-hydroxybutyrate is a novel compound that increases sociability and may function as an antidepressant. Its sale was banned in the US in 1990, in spite of the fact that there is no scientific evidence that it posed any health risk when used responsibly.
GHB, or gamma-hydroxybutyrate, is a normal component of mammalian metabolism. Found naturally in every cell in the human body, it is therefore considered a nutrient. In the brain, the highest amounts are found in the hypothalamus and basal ganglia. GHB is found in greater concentrations in kidney, heart, skeletal muscles, and fat tissues. Some scientists believe it to be a neurotransmitter. It is both a metabolite and precursor of the inhibitory neurotransmitter GABA (gamma-aminobutyric acid, or gamma-aminobutyrate), another nutrient to which it bears a close structural relationship. GHB, however, does not act directly on GABA receptor sites.
GHB was first synthesized about thirty years ago by a French researcher Dr. H. Laborit, who was interested in exploring the effects of GABA in the brain. Laborit synthesized GHB, which substitutes a hydroxy group for an amino group because little or no GABA crosses the blood-brain barrier. This difference allows GHB to cross the blood brain barrier where some of it is metabolized into GABA.
It turns out that Laborit found that GHB exhibited a range of effects beyond those expected from GABA. Over the following years, numerous researchers have extensively studied GHB's effects. It is has come to be used in Europe as a general anesthetic, a treatment for insomnia and narcolepsy, an aid to childbirth, a treatment for alcoholism and alcohol withdrawal syndrome, and for many other uses. In the United States, Canada, Japan and Australia, GHB is used by members of the underground rave culture as a safe alternative to alcohol or ecstasy. Before it was banned, bodybuilders in the United States used GHB to increased growth hormone levels.
GHB actually stimulates pituitary growth hormone (GH) release. One methodologically rigorous Japanese study reported nine-times and sixteen-times increases in growth hormone 30 and 60 minutes respectively after intravenous administration of 2.5 grams of GHB in six healthy men between the ages of twenty-five and forty. GH levels were still seven-times higher at 120 minutes.
The mechanism by which GHB stimulates growth-hormone release is not known. Dopamine activity in the hypothalamus is known to stimulate pituitary release of growth hormone, but GHB inhibits dopamine release at the same time that it stimulates GH release. This suggests that GHB's GH-releasing effect take place through an entirely different mechanism.
GHB is normally available as either the sodium salt (Na-GHB) or the potassium salt (K- GHB) of gamma-hydroxybutyrate. GHB could theoretically be produced in other salt forms but it has not been seen available. Na-GHB is about 10% - 15% stronger than K-GHB by weight so dosage has to be adjusted accordingly.
Professionally produced pharmaceutical-grade GHB will almost always be a white crystalline powder (although there are some exceptions to this in pharmaceutical preparations such as Alcover and Pro-K.) The synthesis of GHB is relatively simple hence the proliferation of some companies selling kits to make GHB and amateur attempts by underground chemists to produce it. GHB produced at home will generally be in a liquid form. I will outline how to make GHB later on in this essay.
While some people consider making their own GH, and this is sometimes necessary in countries like the United States where unscientific political and economic forces cause pharmaceutical GHB to disappear from the market, it's not recommended. It is not advisable to try making GHB yourself if you have no experience with handling chemicals. It is best to try to obtain pharmaceutical GHB from a reputable company. Because the majority of us live in countries where GHB is illegal, such companies are rare. One, Biogenesis Laboratories
