Studies showing bad side of AAS?impossible to find!

[Goldprospector]

I am supposed to be researching a paper for an argumentative essay on the effect of Steriods. I can find all kind of studies about the benifits of proper usage...but I can't find a single thing about and negative effects (with proper usage).

I can find all kind of Dr.'s opinions and quotes, but no legitimate study. I can find problems with "abuse" but nothing on proper use.
My proffesor is not going to like that at all! LOL

 

[i am what i am]

Fuck him. THE TRUTH HURTS.

 

[yatesolympia]

Fuck him. THE TRUTH HURTS.

I'll 2nd that fuck him

 

[macrophage69alpha]

Semin Liver Dis. 1981 May;1(2):116-28. Related Articles, Links


Hepatic lesions caused by anabolic and contraceptive steroids.

Ishak KG.

PIP: Many hepatic lesions, ranging from subcellular alterations to malignant tumors, have been attributed to the use of anabolic steroids (AS) and contraceptive steroids (CS). These lesions that have been attributed to AS and CS are discussed with focus on the following: biochemical changes; subcellular alterations; intrahepatic cholestasis; vascular complications (sinusoidal dilatation, peliosis hepatitis, Budd-Chiari syndrome); hyperplasia and neoplasia (diffuse hyperplasia, nodular transformation, focal nodular hyperplasia, hepatocellular adenoma, hepatocellular carcinoma, and miscellaneous malignant tumors); and miscellaneous effects (effects of preexisting liver disease, cholelithiasis, and pancreatitis). OCs have a number of physiologic effects on the liver. These include decreased bile flow, diminished secretion of organic anions, and decreased synthesis and secretion of bile acids. Retention of bromosulfophthalein has been noted with AS during late pregnancy and in the puerperium. It is well established that the CS can lead to elevations of serum ceruloplasmin and copper levels. Subcellular alterations have been reported in both humans and rats on AS or women on CS and involve multiple organelles of the several systems of the liver. Both AS and CS have been implicated in intrahepatic cholestasis. Jaundice usually develops after 2-5 months of therapy with AS or after 3 months of OC use. The lesions attributed to CS and AS can involve any of the systems of the liver. At times more than 1 system is affected simultaneously. Most of the steroid related lesions resemble similar ones caused by other etiologies. Some, such as peliosis hepatitis, are rarely related to other etiologies, but others can be termed steroid specific. A number of diseases associated with the CS or AS also occur in pregnancy. Acute fatty metamorphosis of pregnancy and the periportal hemorrhagic necrosis characteristic of eclampsia have not been reported in patients on CS. Spontaneous rupture of the liver during pregnancy has not been attributed to the CS.

 

[macrophage69alpha]

J Sci Med Sport. 2003 Sep;6(3):307-12. Related Articles, Links


Blood pressure and rate pressure product response in males using high-dose anabolic androgenic steroids (AAS).

Grace F, Sculthorpe N, Baker J, Davies B.

Centre for Ergogenic Drugs Research, School of Applied Sciences, University of Glamorgan, Pontyridd, Wales, UK.

The literature regarding the blood pressure response to AAS use is equivocal. In addition, there is currently little data available on the Rate Pressure Product (RPP) response to anabolic androgenic steroids (AAS) use. The experimental aim of this study was to investigate the effects of AAS administration in combination with resistance training on blood pressure and rate pressure product in male amateur bodybuilders and compare the results with a morphologically matched, resistance trained control group. Subjects were divided into two groups (n=16 AAS users; n=16 controls). Systolic and Diastolic Blood Pressure, RPP. Resting Heart Rate and Body Composition measurements were obtained before (Pre), during (During) and 6-8 weeks following (Post) the AAS cycle in the AAS users with similar time intervals for the control group. No significant cardiovascular or morphological changes in the control group were found throughout the study. Significant increases in both diastolic (P<0.01) and mean arterial blood pressures (P<0.05) were found from Pre to Post cycle in the AAS group. RPP also increased significantly (P<0.01) from pre to post AAS cycle. All cardiovascular parameters returned to normal baseline measurements between 6 and 8 weeks post cycle. No blood pressure measurements throughout the study were consistent with clinically defined hypertension. The findings indicate that the AAS group exhibited significant increases in standard cardiovascular measurements compared with the control bodybuilders, and provides a contraindication to AAS use especially in borderline hypertensives.

 

[eastcoastplayer]

now you know
big props and some k macro

 

[macrophage69alpha]

Metabolism. 1984 Nov;33(11):971-5. Related Articles, Links


Severe depression of high-density lipoprotein cholesterol levels in weight lifters and body builders by self-administered exogenous testosterone and anabolic-androgenic steroids.

Webb OL, Laskarzewski PM, Glueck CJ.

The effects of nonphysician prescribed, self-obtained, self-administered exogenous anabolic-androgenic steroids and testosterone on plasma total, high- and low-density lipoprotein cholesterol (HDLC, LDLC), and triglycerides were evaluated in 14 adult white men, 11 body builders and 3 power weight lifters. Lipids and lipoprotein cholesterols were quantified during active physical conditioning, both on (for at least 1 month, mean +/- SD 1.8 months) and off (for at least 4 months, 7.3 +/- 2.7 months) self-administered exogenous androgenic steroids. The subjects took 50 to 100 mg methandrostenolone daily plus weekly injections of testosterone 100 to 200 mg and nandrolone decanoate 100 to 200 mg per week. Mean (SD) HDLC on exogenous androgenic steroids, 29 +/- 8 mg/dL, was severely depressed, and was less than 50% of the consistently elevated mean HDLC when exogenous steroids were not used (61 +/- 14 mg/dL, P less than .01 for paired differences). During anabolic steroid use, HDLC was less than or equal to the age- race- and sex-specific 10th percentile in 11 of the 14 men, whereas while off anabolic steroids, HDLC was greater than or equal to the 90th percentile in 7 of the 13 men, and in the top quartile for 3 of the remaining 6 men. Mean LDLC was higher on androgenic steroids (150 +/- 44) than off (125 +/- 38 mg/dL), P less than .05 for paired differences. The ratio of LDLC/HDLC during exogenous steroid use (6.0 +/- 3.7) was nearly triple the ratio obtained when steroids were not taken (2.2 +/- 1.0), P less than .01 for paired differences.

 

[Guvna]

there are tons of studies showing that AAS increases cholesterol (or decreases HDL). Will that count?

Also, I know macro as the study around of the drol that caused cancer in that one lady.

 

[macrophage69alpha]

want to qualify this one (most if not all of these side effects are likely due to extremely high or extremely low oestrogen levels)

Arch Gen Psychiatry. 1994 May;51(5):375-82. Related Articles, Links


Psychiatric and medical effects of anabolic-androgenic steroid use. A controlled study of 160 athletes.

Pope HG Jr, Katz DL.

Biological Psychiatry Laboratory, McLean Hospital, Belmont, Mass.

BACKGROUND: We sought to expand on preliminary findings suggesting that anabolic-androgenic steroids produce psychiatric effects in some athletes who use them. METHODS: We compared 88 athletes who were using steroids with 68 nonusers, using the Structured Clinical Interview for DSM-III-R to diagnose psychiatric syndromes occurring in association with steroid use (if applicable) and in the absence of steroid use. Demographic, medical, and laboratory measures were also performed. RESULTS: Steroid users displayed more frequent gynecomastia, decreased mean testicular length, and higher cholesterol-high-density lipoprotein ratios than nonusers. Most strikingly, 23% of steroid users reported major mood syndromes--mania, hypomania, or major depression--in association with steroid use. Steroid users displayed mood disorders during steroid exposure significantly more frequently than in the absence of steroid exposure (P < .001) and significantly more frequently than nonusers (P < .01). Users rarely abused other drugs simultaneously with steroids. CONCLUSION: Major mood disturbances associated with anabolic-androgenic steroids may represent an important public health problem for athletes using steroids and sometimes for the victims of their irritability and aggression

 

[macrophage69alpha]

I am supposed to be researching a paper for an argumentative essay on the effect of Steriods. I can find all kind of studies about the benifits of proper usage...but I can't find a single thing about and negative effects (with proper usage).

I can find all kind of Dr.'s opinions and quotes, but no legitimate study. I can find problems with "abuse" but nothing on proper use.
My proffesor is not going to like that at all! LOL

even with proper use some people are going to have side effects, even some will have very negative side effects. Though agree there are not really any studies along the lines that you are looking for. The NEJM study is excellent (from a support standpoint).

keep in mind that until about 10 years ago the PDR (physicians desk reference) said that anabolic steroids did not cause muscle growth. Its been a long road of vilification and denial, its going to be a long road to a significant body of good unbiased (as it can be) research.