stopped gains ?

[DaddyX]

i have been on for a while (months) now my question is does your body's receptors shut down and need to be refreshed by taking time off gear. i planned on taking a month off or more because of slowed gains hoping the time off my receptors will be fresh. any thoughts. i might have sounded retarted so i apologize

 

[mrflexdiesel]

Good question bro. I've always wondered about this issue too. You'll probably never get a clear answer though because some will say that your receptors downgrade and you need to take some time off others say that taking larger amounts of AAS actually enhance receptor uptake. I'd like to know the truth on this issue too.

 

[DaddyX]

Good question bro. I've always wondered about this issue too. You'll probably never get a clear answer though because some will say that your receptors downgrade and you need to take some time off others say that taking larger amounts of AAS actually enhance receptor uptake. I'd like to know the truth on this issue too.

yeah, i ask this cause my gains havent been like they should be with still eating and training pretty damn hard. im gonna be doing somewhat of a bulker as i take about 4-5 weeks off and want to make some good gains hoping the time off will "refresh my receptors (something like that)

 

[satchboogie]

man... after 12 weeks of moderate to heavy dosed cycle, my gains stopped too.

 

[DaddyX]

man... after 12 weeks of moderate to heavy dosed cycle, my gains stopped too.

that shit sucks, i want to just keep growing ! bump for abnyone who knows whats going on with receptors and shit

 

[westck]

Does this make any sence?

alot has been said in regards to clearing the receptors and I thought now would be a good time to delve into this subject and simplify things.

Basically, one must view the receptor sites as parking spaces.

Envision a slew of parking spaces that are all empty. Now we are going to call these parking spaces your receptor sites and we shall call steroids the cars. Now I want you to imagine one of those old 1950's style drive up hamburger stands where the girls come up in roller skates and take your order. Typically one would order a burger, fries and a coke--ah the food of the gods--the waitress would take the order, go bring the information to the cook, who would in-turn make the food and the waitress would then bring the food to you and you would then begin eating which is the whole reason you came to the hamburger stand in the first place.

I think everyone can easily understand that. Which means everyone can easily understand all they need to know about the receptor sites because they do the exact same thing. We will keep with this hamburger stand model and explain what happens when you inject steroids and they begin to go to work.

Remember how I said steroids were like the cars and the parking spaces were like the receptor sites? Well it is basically that simple. When you inject testosterone or any one of it's anabolic or androgenic derivatives, you are sending a whole slew of "cars" into your system. Now these "cars" are on a mission--just like you would be if you were hungry and heading to a hamburger stand. They have orders to place with the cells, but before they can place them they must first find a parking space.

Now let's say you have never used steroids before. If this were the case, it would be very much like a hamburger stand that was having a grand opening....lots and lots of empty parking spaces waiting for cars to fill them up and place their orders. The steroids (cars) enter the system and come to a brand new hamburger stand called your cells. Now these cells have never previously been open to the boat-load of anabolics that are now present in the system because they previously only dealt with what your body naturally produced. However, there are lots of extra parking spaces that can be utilized and so the steroids park themselves into these spaces.

Once they are parked a "waitress" called CYCLICl AMP literally crosses the cellular membrane which is totally impenetrably to anything else and takes the order from the steroid. The order is quite simple: Build More Muscle!!

The "waitress" then crosses back through the cellular membrane and brings the order to the "cook" called the Nucleus who begins to fill it by ordering its helpers called Ribosomes to produce muscle protein.. Now different steroids will have slightly different orders in that some may have a bigger order for the cook to fill--such as testosterone. The thing you have to realize is that a lot of times, after the order is placed, the steroid does not necessarily leave the parking space and make it available to other steroids.....it will often sit in the parking space even though it is no longer sending orders to the "waitress" to bring to the "cook", and this is where the problem of "DOWN-REGULATION" comes in. You see even if you send in more and more fresh new "cars" to occupy the receptor spaces, if they are already taken up by old "dead cars" you are shit out of luck.....

This is why you do not continually grow by injecting bigger and bigger doses of steroids. THERE ARE A LIMITED NUMBER OF PARKING SPACES. Now it would not be so bad if all the parking spaces were taken by "cars" that were sending orders to the cook, because that is when you grow. The problem is when there are "cars" that are no longer sending orders and on top of that have dead batteries which is preventing them from exiting the receptors parking space.

This is what the whole point of this article is....TOWING AWAY ALL THE DEAD "CARS" FROM THE RECEPTOR SITES PARKING SPACES AS TO FREE THEM UP FOR NEW, FRESH, HUNGRY "CARS" TO OCCUPY THEM...This will result in new muscle mass!

 

[DaddyX]

how long does it take for the dead cars to leave ? so new ones can park there butts down

 

[Dr. M]

Once they are parked a "waitress" called CYCLICl AMP literally crosses the cellular membrane which is totally impenetrably to anything else and takes the order from the steroid. The order is quite simple: Build More Muscle!!

The "waitress" then crosses back through the cellular membrane and brings the order to the "cook" called the Nucleus who begins to fill it by ordering its helpers called Ribosomes to produce muscle protein...

I don't know if this analogy/writing was yours or someone else's, and I'm not here to start a flame war. I just want to get that out in the open RIGHT NOW. This is NOT intended to start a riot on the boards.

Cyclic AMP is synthesized inside the cell; it doesn't cross the cell membrane at any time under normal physiological conditions. Cyclic AMP is a second messenger seen in cases of adrenergic, insulinic, and various peptide hormone signalling pathways. It is synthesized via adenylate cyclase, which resides on the inner membrane surface due to its hydrophobic lipid tail. Adenylate cyclase is activated by a variety of G-proteins, which (very briefly) are activated by receptor conformation/phosphorylation state changes due to external receptor substrate binding.

cAMP is NOT seen in steroid signalling, or if it is, this is not because of the integral membrane receptor/G protein pathway.

The reason for this is that in peptide/integral membrane receptor signalling the first messenger (hormone) cannot cross the cell membrane. Steroids are lipid-soluble, and easily cross the lipid bilayer to enter the cell. Once there, they can diffuse to the nucleus and act on the sterol regulatory elements and various transcriptional promoters which induce an anabolic state in a variety of ways.

The transcriptional activation produces mRNA (messenger RNA) which encodes for various proteins, and these mRNAs are translated by ribosomes. There is no direct effect of the steroid itself on the ribosome; ribosome activity is governed by assembly/disassembly which is mediated by mRNA levels in the cell, although your statement that ribosomes are stimulated to increase protein synthesis is ultimately correct (even though your proposed mechanism of activation is not).

-M

 

[DaddyX]

i dont know all this scientific stuff. how long does it take for rweceptors to be cleaned out or atealst ready for some new cars ?

 

[westck]

Dr, M

No I did not write the artical. I read it, found it interesting that it had been witten in a way almost anyone could understand. Thought others may find it interesting also....

Does this make sense?

 

[Dr. M]

Depends on what you're using.

It's not always a receptor 'cleaning' per se; it's often a receptor re-synthesis... the bound receptor is degraded and new receptor protein is synthesized.

Ask BodyByFinaplix - he loves tapping in on this stuff.

-M

 

[DaddyX]

Depends on what you're using.

It's not always a receptor 'cleaning' per se; it's often a receptor re-synthesis... the bound receptor is degraded and new receptor protein is synthesized.

Ask BodyByFinaplix - he loves tapping in on this stuff.

-M

so if ones not to take a very long break atleast change the compounds used in a cycle ?

 

[mtex1]

man... after 12 weeks of moderate to heavy dosed cycle, my gains stopped too.

you the same satchboogie @ bolex & offshore

 

[Dr. M]

so if ones not to take a very long break atleast change the compounds used in a cycle ?

Not necessarily... you'd need to take a break to clean things up, I would imagine.

However, and this is JUST A THEORY which popped into my head... proviron binds to SHBG and causes release of previously bound sex hormone... I wonder if using proviron after a cycle might actually increase the "cleanliness" (if you want to use those terms) of your AR's in general for a given period of time.

Now, that's probably bunk, but it might bear some looking into... if proviron does it with SHBG, it might do it with AR's. Then, after a shorter recovery period, large-scale frontloading with another (or the same) compound might displace the proviron? It seems like a pretty big stretch to me... don't really think it'd be possible.

But you might want to ask bros about their experiences with doing something like that, if any have pulled it off...

-M

 

[DaddyX]

thanks for the good responses

 

[mrflexdiesel]

I don't know if this analogy/writing was yours or someone else's, and I'm not here to start a flame war. I just want to get that out in the open RIGHT NOW. This is NOT intended to start a riot on the boards.

Cyclic AMP is synthesized inside the cell; it doesn't cross the cell membrane at any time under normal physiological conditions. Cyclic AMP is a second messenger seen in cases of adrenergic, insulinic, and various peptide hormone signalling pathways. It is synthesized via adenylate cyclase, which resides on the inner membrane surface due to its hydrophobic lipid tail. Adenylate cyclase is activated by a variety of G-proteins, which (very briefly) are activated by receptor conformation/phosphorylation state changes due to external receptor substrate binding.

cAMP is NOT seen in steroid signalling, or if it is, this is not because of the integral membrane receptor/G protein pathway.

The reason for this is that in peptide/integral membrane receptor signalling the first messenger (hormone) cannot cross the cell membrane. Steroids are lipid-soluble, and easily cross the lipid bilayer to enter the cell. Once there, they can diffuse to the nucleus and act on the sterol regulatory elements and various transcriptional promoters which induce an anabolic state in a variety of ways.

The transcriptional activation produces mRNA (messenger RNA) which encodes for various proteins, and these mRNAs are translated by ribosomes. There is no direct effect of the steroid itself on the ribosome; ribosome activity is governed by assembly/disassembly which is mediated by mRNA levels in the cell, although your statement that ribosomes are stimulated to increase protein synthesis is ultimately correct (even though your proposed mechanism of activation is not).

-M

Hugh? I used to think I was a very intelligent person. That was until now. Damn, you must really be a doctor M?

 

[Dr. M]

Hugh? I used to think I was a very intelligent person. That was until now. Damn, you must really be a doctor M?

Thanks bro, but no... I'm doing my Ph.D. in the Faculty of Medicine and Dentistry at my University (Dept. of Biochemistry) and this sort of stuff is what Biochemists work on.

It's just my background. But I'm not a medical doctor, nor is it likely that I ever will be... I'll have the title Dr. , but not M.D. I figure I can help more in a research context than in a clinical context... as much as I'd love to be able to write myself (and good bros such as yourselves!) scripts for test, var, hGH, and all the other goodies!

-M

 

[mrflexdiesel]

Thanks bro, but no... I'm doing my Ph.D. in the Faculty of Medicine and Dentistry at my University (Dept. of Biochemistry) and this sort of stuff is what Biochemists work on.

It's just my background. But I'm not a medical doctor, nor is it likely that I ever will be... I'll have the title Dr. , but not M.D. I figure I can help more in a research context than in a clinical context... as much as I'd love to be able to write myself (and good bros such as yourselves!) scripts for test, var, hGH, and all the other goodies!

-M

Very nice!

 

[Dr. M]

Thanks bro...

... and working closely with many medicine students who did their biochemistry degrees and sat next to me in classes for 3-4 years may have its "privileges" once they're full-fledged docs.

I guess time will tell...

-M

 

[silver_shadow]

^
lucky bum!

 

[DaddyX]

^^^^bump