Depending on the drug and the resulting E2 levels:
--Poor lipid profile.
--Bone density loss.
--Negative changes in libido/mood.
--Skin, hair changes.
--Potential changes to connective tissues and healing abilities.
--Changes in fat distribution including some potentially very negative changes in visceral fat accumulation.
No idea. We know that elderly men will often have increased DHT levels. There's a definite link between DHT elevations and visceral fat accumulation, as seen in European men using DHT as a form of HRT. There's also a definite link between visceral fat and cardiovascular risk. All this takes time though. Still reducing T to E2 conversion leaves another pathway open...
The data on E reduction/elimination is clearer. Women experience menopause in their late 40's and bone density problems start showing up in their early to mid 60's.