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Here is the rough draft i promised many weeks ago.......nothing new to you guys, but it should be published within the year.
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CONTEXT: Chronically ill patients such as those with spinal cord injury would benefit from being in an anabolic state versus a catabolic state. The use of anabolic medications can promote the body into synthesizing protein and increasing weight so as to improve the processes necessary to heal and be discharged in a timely manner from the inpatient unit. However, the fear of adverse effects and the stigma against anabolic steroids has prevented its use.
OBJECTIVE: To determine whether oxandrolone supplementation would significantly improve protein stores in spinal cord injury patients, while at the same time having minimal adverse effects as compared to many commonly used medications.
DESIGN: Prospective chart review in patients admitted to the rehab unit from 1998-2001.
SETTING: The Institute of Rehabilitation and Research (TIRR) in Houston, Texas.
PATIENTS: 50 acute and chronic spinal cord injury patients with multiple medical problems who were in the TIRR SCI Unit.
INTERVENTION: Oxandrolone was given either oral or via percutaneous enteral gastrostomy tube (PEG).
MAIN OUTCOME MEASURES: Protein stores were observed by measuring prealbumin, albumin, and total protein stores. The patients were also weighed periodically. To account for adverse effects, liver function tests were evaluated. The Oxandrolone group of 25 patients was compared to 25 selected patients who did not receive Oxandrolone.
RESULTS:
CONCLUSION: A moderate dosage of Oxandrolone improved protein stores and helped in wound healing, strength, and lean body mass. Patients had no adverse effects that could be directly attributed to the Oxandrolone.
T
CONTEXT: Chronically ill patients such as those with spinal cord injury would benefit from being in an anabolic state versus a catabolic state. The use of anabolic medications can promote the body into synthesizing protein and increasing weight so as to improve the processes necessary to heal and be discharged in a timely manner from the inpatient unit. However, the fear of adverse effects and the stigma against anabolic steroids has prevented its use.
OBJECTIVE: To determine whether oxandrolone supplementation would significantly improve protein stores in spinal cord injury patients, while at the same time having minimal adverse effects as compared to many commonly used medications.
DESIGN: Prospective chart review in patients admitted to the rehab unit from 1998-2001.
SETTING: The Institute of Rehabilitation and Research (TIRR) in Houston, Texas.
PATIENTS: 50 acute and chronic spinal cord injury patients with multiple medical problems who were in the TIRR SCI Unit.
INTERVENTION: Oxandrolone was given either oral or via percutaneous enteral gastrostomy tube (PEG).
MAIN OUTCOME MEASURES: Protein stores were observed by measuring prealbumin, albumin, and total protein stores. The patients were also weighed periodically. To account for adverse effects, liver function tests were evaluated. The Oxandrolone group of 25 patients was compared to 25 selected patients who did not receive Oxandrolone.
RESULTS:
CONCLUSION: A moderate dosage of Oxandrolone improved protein stores and helped in wound healing, strength, and lean body mass. Patients had no adverse effects that could be directly attributed to the Oxandrolone.
