quick cutting idea

[spentagn]

Here's something I'm thinking about trying real quick before my winter bulking cycle.

200mg/day for 7 days (I'd use more, but this is all I have left)
Yohimburn applied daily
ECA twice daily

I'm thinking about adding Chinese arimidex (I can get a few for free) every day.

This coupled with a clean diet should drop some pounds, no?

 

[Nimrod25]

200mg DNP?

 

[spentagn]

crystal, sorry

 

[spentagn]

bump

 

[malhavoc]

Here's something I'm thinking about trying real quick before my winter bulking cycle.

200mg/day for 7 days (I'd use more, but this is all I have left)
Yohimburn applied daily
ECA twice daily

I'm thinking about adding Chinese arimidex (I can get a few for free) every day.

This coupled with a clean diet should drop some pounds, no?

I did almost the exact same thing but for only 6 days, I dropped 6 pounds.

 

[Par Deus]

In regards to the use of Yohimburn, in case everyone is unaware, with typical transdermal delivery, drugs that penetrate the skin barrier and traverse the epidermis and dermis are rapidly taken up by the dermal microvasculature, where they are delivered systemically (just like with orals) -- this is very well characterized in the literature (1,2,3) -- with direct tissue penetration being limited to 1-4 mm, which obviously is not exactly deep into the adipose tissue.

Let me repeat, if nothing is done to bypass the dermal microvasculature, our drug enters systemic circulation before it ever reaches the adipose tissue.

And, considering that Yohimbine HCl has good oral bioavailability, if the dermal microvasculature is not taken into account, we end up with a product that not only does not localize delivery, it does not even deliver it systemically as efficiently as an oral would do. Considering these products cost far more than there oral counterparts, and could also be thought of as inconvenient in that you have to rub them on your body, wait for them to dry, etc., any supplement developer who does not take dermal uptake into account has obviously missed the boat quite badly. And, guess what... there is only one substance I have seen in the literature that facilitates this. And, guess what else... Yohimburn does employ it.


References:

1. Roberts MS. Targeted drug delivery to the skin and deeper tissues: role of physiology, solute structure and disease.Clin Exp Pharmacol Physiol 1997 Nov;24(11):874-9

2. Singh P, Roberts MS. Skin permeability and local tissue concentrations of nonsteroidal anti-inflammatory drugs after topical application. J Pharmacol Exp Ther 1994 Jan;268(1):144-51

3. Singh P, Roberts MS Dermal and underlying tissue pharmacokinetics of lidocaine after topical application..J Pharm Sci 1994 Jun;83(6):774-82

 

[spentagn]

That's interesting considering all the support it's gotten as of late. It's also interesting seeing as how I dropped $60 on it today.

 

[Par Deus]

Yohimbine is an excellent fat burner. I prefer it to EC for this purpose. So, one WOULD expect fat loss, assuming submaintenence calories.

But, one would also expect fat loss with oral Yohimbine HCl, assuming submaintenence calories.

 

[spentagn]

One would expect fat burning with submaintenance calories. Why bother with anything if that's the case?

 

[Par Deus]

Because you can increase it, as well as decrease LBM losses with certain compounds, including EC and yohimbine.

Yohimbine will be particularly effective in areas with high densities of alpha 2 receptors.