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"The study of involvement of PGs in the pathogenesis and progression of cancer is currently a lively field of research. The evidence weighs heavily in favor of such a role in many types of cancer. This is based on the observation of high PG levels and elevated expression of synthetic enzymes in various types of tumors. Such a role for PGs is also supported by the numerous animal investigations and human epidemiological studies showing that NSAIDs prevent development of cancer. However, the recent demonstration that these drugs cause apoptosis, and that related anti-cancer drugs that also cause apoptosis do not inhibit PG synthesis, suggest that the story is far from clear. Hopefully, the recently developed knockout and transgenic mouse models will provide the definitive information that is needed. A clearer demonstration that PG synthesis contributes to the development and/or growth of several types of malignancies offers the opportunity for improved approaches to the prevention of cancer."
This is a summary of an article I came across and was briefly reading it. It has to do with the involvment of PG's involvment and possible development of malignancies and tumor growth. Whereas PG's may exert a supportive enviroment for tumor growth, anti-inflammatory agents, NSAIDS, show to reduce carcinogenesis. The antineoplastic properties of NSAIDS have been attributed to the suppression of PG levels by inhibiting COX1 and 2 activity. PG's causes cell proliferation, however it is unclear whether or not the proliferation and the effect of the target tissue effects are the same for both non-malignant tissue and malignant tissue. PGE1, PGE2, and PGF2a produced a marked increase in DNA, RNA and protein synthesis, which suggests PG's involvment in regulatory functions in epidermal cells. PGs also can be involved in immune function modulation. High levels of the PGE2 eicosaniod seem to suppress immune function and impair the killing of malignant cells. However this effects seems to be unique to PGE2 and not the other eicosaniods.
So from reading this article it is clear that PG's show a role in cell proliferation and support for carcinogenic growth. However it is unclear which PG's may have more of an effect towards malignancies and by which mechanisms they work through.
I thought it was interesting, a little involved though, but none the less informative. It may be something of interest to research more thouroughly for those interested in using PGF2a, and whether or not through the use of PGF2 could the individual potentially be risking the development or proliferation of cancer.
This is a summary of an article I came across and was briefly reading it. It has to do with the involvment of PG's involvment and possible development of malignancies and tumor growth. Whereas PG's may exert a supportive enviroment for tumor growth, anti-inflammatory agents, NSAIDS, show to reduce carcinogenesis. The antineoplastic properties of NSAIDS have been attributed to the suppression of PG levels by inhibiting COX1 and 2 activity. PG's causes cell proliferation, however it is unclear whether or not the proliferation and the effect of the target tissue effects are the same for both non-malignant tissue and malignant tissue. PGE1, PGE2, and PGF2a produced a marked increase in DNA, RNA and protein synthesis, which suggests PG's involvment in regulatory functions in epidermal cells. PGs also can be involved in immune function modulation. High levels of the PGE2 eicosaniod seem to suppress immune function and impair the killing of malignant cells. However this effects seems to be unique to PGE2 and not the other eicosaniods.
So from reading this article it is clear that PG's show a role in cell proliferation and support for carcinogenic growth. However it is unclear which PG's may have more of an effect towards malignancies and by which mechanisms they work through.
I thought it was interesting, a little involved though, but none the less informative. It may be something of interest to research more thouroughly for those interested in using PGF2a, and whether or not through the use of PGF2 could the individual potentially be risking the development or proliferation of cancer.
yeah Ranger I've heard the same thing about receptor upregulation from the use of PGF2. A muscle biopsy I believe was used and showed a higher concentration of the androgen receptor in the muscle tissue over someone that has not used PGF2.
