Oxandrolone -- not liver toxic!?!

[Herbiv0re]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&list_uids=15300183

Surgery. 2004 Aug;136(2):219-24. Related Articles, Links


Effects of long-term oxandrolone administration in severely burned children.

Murphy KD, Thomas S, Mlcak RP, Chinkes DL, Klein GL, Herndon DN.

Department of Surgery, The University of Texas Medical Branch, Shriners Hospitals for Children, Galveston, TX 77550, USA.

BACKGROUND: Severe burns cause exaggerated catabolism of muscle protein and inhibit bone deposition. Weakness and bony growth arrest interfere with rehabilitation. The purpose of this study was to determine whether oxandrolone administration for 1 year after the burn reverses muscle and bone catabolism in hypermetabolic pediatric burn patients. METHODS: Children with burns greater than 40% total body surface area were enrolled into a randomized controlled trial to receive oxandrolone as a long-term anabolic agent. All patients received similar clinical care. Subjects were studied at discharge (95% healed) and at 6, 9, and 12 months after the burn, after treatment with 0.1 mg/kg po bid or placebo. Serum hepatic transaminases were measured. Lean body mass (LBM), bone mineral content (BMC,) and bone mineral density (BMD) were measured by dual energy x-ray absorptiometry. Patients completed a safety questionnaire and were reviewed clinically at intervals. RESULTS: The groups were similar in age, weight, and total body surface area burned. LBM was significantly greater with oxandrolone at 6, 9, and 12 months after the burn (P < .001) and BMC at 12 months (P < .016). Age- and gender-matched BMD z scores were significantly better with oxandrolone (P < .039). Liver transaminases were unaffected. CONCLUSIONS: Long-term administration of oxandrolone safely improves LBM, BMC, and BMD in severely burned children. Copyright 2004 Elsevier Inc.

PMID: 15300183 [PubMed - in process]

 

[poantrex]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&list_uids=15300183

Surgery. 2004 Aug;136(2):219-24. Related Articles, Links


Effects of long-term oxandrolone administration in severely burned children.

Murphy KD, Thomas S, Mlcak RP, Chinkes DL, Klein GL, Herndon DN.

Department of Surgery, The University of Texas Medical Branch, Shriners Hospitals for Children, Galveston, TX 77550, USA.

BACKGROUND: Severe burns cause exaggerated catabolism of muscle protein and inhibit bone deposition. Weakness and bony growth arrest interfere with rehabilitation. The purpose of this study was to determine whether oxandrolone administration for 1 year after the burn reverses muscle and bone catabolism in hypermetabolic pediatric burn patients. METHODS: Children with burns greater than 40% total body surface area were enrolled into a randomized controlled trial to receive oxandrolone as a long-term anabolic agent. All patients received similar clinical care. Subjects were studied at discharge (95% healed) and at 6, 9, and 12 months after the burn, after treatment with 0.1 mg/kg po bid or placebo. Serum hepatic transaminases were measured. Lean body mass (LBM), bone mineral content (BMC,) and bone mineral density (BMD) were measured by dual energy x-ray absorptiometry. Patients completed a safety questionnaire and were reviewed clinically at intervals. RESULTS: The groups were similar in age, weight, and total body surface area burned. LBM was significantly greater with oxandrolone at 6, 9, and 12 months after the burn (P < .001) and BMC at 12 months (P < .016). Age- and gender-matched BMD z scores were significantly better with oxandrolone (P < .039). Liver transaminases were unaffected. CONCLUSIONS: Long-term administration of oxandrolone safely improves LBM, BMC, and BMD in severely burned children. Copyright 2004 Elsevier Inc.

PMID: 15300183 [PubMed - in process]

They were using .1mg/kg, which is far less than what a bodybuilder would use. That is like 7mg for a 150 lb person.

 

[CENTURION44]

has anyone tried any of these legal alternatives???

 

[KOArtist]

Isn't ANYTHING 17-aa liver toxic? Even if it was like Gerbers baby food or something?lol

 

[TheAssholeFomerlyKnownAsDBBT]

Isn't ANYTHING 17-aa liver toxic? Even if it was like Gerbers baby food or something?lol

Your avatar is the FUCKING SHIT i want it!

 

[maikelmd]

They were using .1mg/kg, which is far less than what a bodybuilder would use. That is like 7mg for a 150 lb person.

Yep, but they were using it for one year!! And, yes, this is far too much in my opinion.

 

[Jayy5921]

Oxandrolone like all 17-aa orals is toxic to liver in certain doses. A good tab to use if worried about liver toxicity would be Primobolan tabs. They are not 17-aa however they are extremely pricy.

 

[DIVISION]

Oxandrolone like all 17-aa orals is toxic to liver in certain doses. A good tab to use if worried about liver toxicity would be Primobolan tabs. They are not 17-aa however they are extremely pricy.

Agree about Anavar being as liver toxic as any 17AA oral......

Primo tabs are overpriced overrated just like Anavar.

 

[thx9000]

Agree about Anavar being as liver toxic as any 17AA oral......

Primo tabs are overpriced overrated just like Anavar.

Not necessarily true.

Link
Unlike other anabolic steroids, such as testosterone, oxandrolone is minimally metabolized by the liver, thereby avoiding most drug interactions and the liver toxicity often seen with other steroids. Even people whose livers where badly damaged by alcohol, and therefore were unable to take many drugs, did well on oxandrolone.

Link
Anavar is also a 17alpha alkylated oral steroid, carrying an alteration that is noted for putting stress on the liver. It is importarnt to point out however that to spite this alteration oxandrolone is generally very well tolerated, While liver enzyme tests will occasionally show elevated values, actual damage due to this steroid is not a statistical problem.

Link
Unlike other orally administered C17alpha-alkylated AASs, the novel chemical configuration of oxandrolone confers a resistance to liver metabolism as well as marked anabolic activity. In addition, oxandrolone appears not to exhibit the serious hepatotoxic effects (jaundice, cholestatic hepatitis, peliosis hepatis, hyperplasias and neoplasms) attributed to the C17alpha-alkylated AASs.

Link
Of 43 patients originally recruited, 39 (19 men, 20 women) with typical clinical and laboratory features of alcoholic hepatitis (11 Child's-Pugh class B; 28 class C) were admitted to a metabolic unit and completed a 35-day three-phase protocol...during which routine and special quantitative tests of liver function (galactose and antipyrine metabolism)...oxandrolone (20 mg orally four times a day) plus standard therapy...during which special studies of liver functions and volumes and leucine metabolism were repeated...Overall, with time, patients showed highly significant improvements in most clinical and laboratory features. For most standard laboratory tests (e.g., serum albumin, transferrin, prothrombin time) improvements were more marked in patients treated with nutritional supplementation and/or oxandrolone than in those given standard therapy alone. Liver volumes fell in all treatment groups, with greater improvement in those treated with nutritional supplementation....We conclude that the addition of nutritional supplementation and oxandrolone to standard therapy of moderately severe or severe alcoholic hepatitis is well tolerated, and leads to more rapid improvement in the laboratory parameters measured.

 

[Herbiv0re]

They were using .1mg/kg, which is far less than what a bodybuilder would use. That is like 7mg for a 150 lb person.

As far as i know "0.1 mg/kg po bid" is 0.2mg/kg daily.
In my case : 98kg x 0.2mg = 19.6mg/day

That's not bad, full time for one year....with no negative effect on the liver

I know, maybe those kids were only 30kg and only using 6mg/day. But don't they have smaller livers

 

[ripper2]

i was on 38mg/day for about 6-7wks and had liver enzymes checked and everything looked great, not even close to edge of normal range.

 

[V-Machine]

As far as i know "0.1 mg/kg po bid" is 0.2mg/kg daily.
In my case : 98kg x 0.2mg = 19.6mg/day

That's not bad, full time for one year....with no negative effect on the liver

I know, maybe those kids were only 30kg and only using 6mg/day. But don't they have smaller livers

Not to mention that their bodies were under a lot of stress when the drugs were administered.

The dose you gave above is only half of what many people use. Probably a good comparison considering the nature of the subjects.

 

[_Yossarian_]

Agree about Anavar being as liver toxic as any 17AA oral......

Primo tabs are overpriced overrated just like Anavar.

primo tabs are useless in IMO unless youre a woman. Var on the other hand, is definitely not overrated. In fact Id say it was one of the best compounds available considering its benifits/sides ratio. Find a UG lab you can trust, and its even reasonably priced.

 

[HotYngSwngr]

Good to hear!!! I am about to do a 10 wk cycle that is HEAVY in Oxandrine...now I can rest easy!!!

 

[KOArtist]

Your avatar is the FUCKING SHIT i want it!

feel free, I changed mine to a post-fight photo of my last opponent, lol. Just go to google images and search for detroit tigers, then u gotta shrink it a little. peace