optimum gla dosage? fonz?

[DaMan]

tired of searching, there's like a million threads containing gla and none have the answer.

what's the current optimum gla dosage? fonz, what's your dosage? i guess i can just divide that in half

 

[macrophage69alpha]

what's the current optimum gla dosage? fonz, what's your dosage? i guess i can just divide that in half

 

[macrophage69alpha]

btw- a yield of 800-1000mg of GLA (from borage) is considered to be somewhere near the effective dose (at least with respect to glucose clearance).. something to ponder...too high levels may actually impede growth by interfering with prostaglandin synthesis

 

[DaMan]

800-1000mg per meal or per day? what about on a low to no-carb diet?

 

[Fonz]

btw- a yield of 800-1000mg of GLA (from borage) is considered to be somewhere near the effective dose (at least with respect to glucose clearance).. something to ponder...too high levels may actually impede growth by interfering with prostaglandin synthesis

Quite the opposite MP.

GLA blocks series 2 prostaglandins(PGE2), therefore shifting the prostaglandin balance that is usually 1:1 (PGF2AGE2) to the PGF2A side...creating a thermogenic/lipolytic environment.

This is probably the only night-time lipolytic that actually works.

Forskholin as we all know was a total bust.

1500-2000mg GLA right before bed......will have a pronounced effect on lipolysis.

I really do not know where you get this "GLA interferes with prostaglandin synthesis"?

The only thing that I know that does that is aspirin, which lowers overral prostaglandin synthesis, but still maitains the 1:1 PGF2AGE2 ratio at the lowered PG levels.

Fonz

 

[macrophage69alpha]

actually the opposite
Bratisl Lek Listy. 2002;103(3):101-7. Related Articles, Links


The effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandin synthesis in older subjects.

Hornych A, Oravec S, Girault F, Forette B, Horrobin DF.

Broussais Hospital, Paris, France. [email protected]

Senescence is associated with a decreased activity of enzyme delta-6 desaturase, which converts linoleic acid to gamma-linolenic acid. This enzymatic defect may alter the composition of plasma and membrane lipids, and influences the biosynthesis of renal prostaglandins. Exogenous supplementation of GLA during 3 months increases the plasma level of dihomo-gamma-linolenic acid (p < 0.002), and to a smaller degree, the level in erythrocyte membrane lipids. This treatment was associated with a beneficial reduction of cardiovascular risk factors (arterial hypertension, total cholesterol, apolipoprotein B, HDL-cholesterol, apolipoprotein A-I) and the renal function has become stable reached. Epogam treatment also increased the biosynthesis of renal prostaglandins, especially that of prostaglandin E2, which has a vasodilatory effect on vessel walls and reduces the elevated blood pressure. CONCLUSION: Dietary supplementation of essential fatty acids such as gamma-linolenic acid to old subjects has beneficial effect on their health condition. (Tab. 6, Fig. 5, Ref. 37.)

so it increases pge2

 

[macrophage69alpha]

though it has widespread health benefits.. at high doses it can have impact on prostaglandins that MAY lead to reduction of anabolism.. stress on MAY...

 

[Fonz]

The effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandin synthesis in older subjects.


[/B]

I think the "older subjects" line sums up the total inadequacy/irrelevancy of this study to young healthy adults who have OPTIMAL prostaglandin levels.

Moral of my threads, is that GLA is STILL a potent supplement in the fat busting arsenal. Specially at night.

Fonz

 

[macrophage69alpha]

Moral of my threads, is that GLA is STILL a potent supplement in the fat busting arsenal. Specially at night.

Fonz

not arguing that point.. only that TOO MUCH could lead to negative impact, possibly, on PG's