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Niacin, wtf ??
- Thread starter rjl296
- Start date
M
Mr.X
Guest
rjl296 said:
There is only one Niacin I know of and that's Niacin-Bacterium...why are you taking it?
Bacillus niacini Nagel and Andreesen 1991VP (Bacteria) - see also Bacterial Nomenclature Up-to-Date
DSM No. 2923
= IFO 15566
Information <- J.C. Ensign. Soil. Type strain. Taxonomy/description (3956, 4628, 4629, 4630). Formation of a soluble blue pigment (2902). Utilizes nicotinic acid (2902). (Medium 1, 30°C).
M
Mr.X
Guest
rjl296 said:
well, now you know not to take it....seems like the bacterial culture didn't respond well w/ your system.
Mr.X
Yep, Nordstrom is partially correct in that the cappilaries become dilated.
Here is an EXCELLENT explanation on Niacin given by cockdezl a while back.
cockdezl
Moderator
"Niacin causes the release of prostaglandin D2 from the tissue beds of causing a capillary dilation."
quote:
--------------------------------------------------------------------------------
Title
Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid.
Author
Morrow JD; Parsons WG 3d; Roberts LJ 2d
Address
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232.
Source
Prostaglandins, 1989 Aug, 38:2, 263-74
Abstract
Nicotinic acid (niacin) is a B vitamin which is also a potent hypolipidemic agent. However, intense flushing occurs following ingestion of pharmacologic doses of niacin which greatly limits its usefulness in treating hyperlipidemias. Previous studies have demonstrated that niacin-induced flushing can be substantially attenuated by pre-treatment with cyclooxygenase inhibitors, suggesting that the vasodilation is mediated by a prostaglandin. However, the prostaglandin that presumably mediates the flush has not been conclusively determined. In this study we report the finding that ingestion of niacin evokes the release of markedly increased quantities of PGD2 in vivo in humans. PGD2 release was assessed by quantification of the PGD2 metabolite, 9 alpha, 11 beta-PGF2, in plasma by gas chromatography mass spectrometry. Following ingestion of 500 mg of niacin in three normal volunteers, intense flushing occurred and plasma levels of 9 alpha, 11 beta-PGF2 were found to increase dramatically by 800, 430, and 535-fold. Levels of 9 alpha, 11 beta-PGF2 reached a maximum between 12 and 45 min. after ingesting niacin and subsequently declined to near normal levels by 2-4 hours. Levels of 9 alpha, 11 beta-PGF2 in plasma correlated with the intensity and duration of flushing that occurred in the 3 volunteers. Release of PGD2 was not accompanied by a release of histamine which was assessed by quantification of plasma levels of the histamine metabolite, N tau-methylhistamine. This suggests that the origin of the PGD2 release is not the mast cell. Only a modest increase (approximately 2-fold) in the urinary excretion of the prostacyclin metabolite, 2,3-dinor-6-keto-PGF1 alpha, occurred following ingestion of niacin and no increase in the excretion of the major urinary metabolite of PGE2 was found. These results indicate that the major vasodilatory PG released following ingestion of niacin is PGD2. The fact that markedly increased quantities of PGD2 are released suggests that PGD2 is the mediator of niacin-induced vasodilation in humans.
BMJ
Here is an EXCELLENT explanation on Niacin given by cockdezl a while back.
cockdezl
Moderator
"Niacin causes the release of prostaglandin D2 from the tissue beds of causing a capillary dilation."
quote:
--------------------------------------------------------------------------------
Title
Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid.
Author
Morrow JD; Parsons WG 3d; Roberts LJ 2d
Address
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232.
Source
Prostaglandins, 1989 Aug, 38:2, 263-74
Abstract
Nicotinic acid (niacin) is a B vitamin which is also a potent hypolipidemic agent. However, intense flushing occurs following ingestion of pharmacologic doses of niacin which greatly limits its usefulness in treating hyperlipidemias. Previous studies have demonstrated that niacin-induced flushing can be substantially attenuated by pre-treatment with cyclooxygenase inhibitors, suggesting that the vasodilation is mediated by a prostaglandin. However, the prostaglandin that presumably mediates the flush has not been conclusively determined. In this study we report the finding that ingestion of niacin evokes the release of markedly increased quantities of PGD2 in vivo in humans. PGD2 release was assessed by quantification of the PGD2 metabolite, 9 alpha, 11 beta-PGF2, in plasma by gas chromatography mass spectrometry. Following ingestion of 500 mg of niacin in three normal volunteers, intense flushing occurred and plasma levels of 9 alpha, 11 beta-PGF2 were found to increase dramatically by 800, 430, and 535-fold. Levels of 9 alpha, 11 beta-PGF2 reached a maximum between 12 and 45 min. after ingesting niacin and subsequently declined to near normal levels by 2-4 hours. Levels of 9 alpha, 11 beta-PGF2 in plasma correlated with the intensity and duration of flushing that occurred in the 3 volunteers. Release of PGD2 was not accompanied by a release of histamine which was assessed by quantification of plasma levels of the histamine metabolite, N tau-methylhistamine. This suggests that the origin of the PGD2 release is not the mast cell. Only a modest increase (approximately 2-fold) in the urinary excretion of the prostacyclin metabolite, 2,3-dinor-6-keto-PGF1 alpha, occurred following ingestion of niacin and no increase in the excretion of the major urinary metabolite of PGE2 was found. These results indicate that the major vasodilatory PG released following ingestion of niacin is PGD2. The fact that markedly increased quantities of PGD2 are released suggests that PGD2 is the mediator of niacin-induced vasodilation in humans.
BMJ
gsxr1000
New member
Yeah niacin has some kind of dialating effect on your blood vessels. I once tried this tanning cream called high octane BBQ tanning sauce (I've never seen a big red warning label on tanning cream like this had) ....................or something to that effect once, that had a high amounts of niacin in it's ingredients. I smeared some on my arms chest and back at the beach once..............within about 2 minutes it felt like someone has sprayed me down with gasoline and set me on fire, it burned like crazy.
On a side note, I've heard about guys taking Niacin before a show to give their body a more brighter redder glow. Ehhhh, I don't know. But yeah, if you must take it, use the no-flush variety.
On a side note, I've heard about guys taking Niacin before a show to give their body a more brighter redder glow. Ehhhh, I don't know. But yeah, if you must take it, use the no-flush variety.
