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MTS
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Fispemifene When taken once daily over a one month period, can significantly increase circulating testosterone levels. This drug appears to be dose dependent in its effects (300 mg has stronger effects than 100mg).
This may be something AG-guys might want to look into. (hint hint)
Fispemifene is a product candidate for the treatment of the symptoms of andropause. Unlike testosterone replacement therapies, fispemifene utilizes the body's normal feedback mechanism to increase testosterone levels into, but not beyond, the normal range. By blocking estrogen feedback to the pituitary with a drug like fispemifene, the pituitary increases LH and FSH secretion which increases testosterone secretion. As these rising testosterone levels feedback on the pituitary, LH and FSH secretion return toward normal and testosterone reaches a new, albeit higher, steady state level. Based on this mechanism of action, fispemifene is being studied for the treatment of androgen deficiency and associated symptoms in aging men. We believe that increased production of testosterone may treat many of the symptoms of andropause. In a multiple-dose Phase I study we conducted in healthy men, fispemifene increased total testosterone levels after 28 days of treatment.
This may be something AG-guys might want to look into. (hint hint)
Fispemifene is a product candidate for the treatment of the symptoms of andropause. Unlike testosterone replacement therapies, fispemifene utilizes the body's normal feedback mechanism to increase testosterone levels into, but not beyond, the normal range. By blocking estrogen feedback to the pituitary with a drug like fispemifene, the pituitary increases LH and FSH secretion which increases testosterone secretion. As these rising testosterone levels feedback on the pituitary, LH and FSH secretion return toward normal and testosterone reaches a new, albeit higher, steady state level. Based on this mechanism of action, fispemifene is being studied for the treatment of androgen deficiency and associated symptoms in aging men. We believe that increased production of testosterone may treat many of the symptoms of andropause. In a multiple-dose Phase I study we conducted in healthy men, fispemifene increased total testosterone levels after 28 days of treatment.
