due too receptor downregulation clen needs to be run on a 2 week on/ 2 week off protocol. as far as cytomel dosaging. you should start at about 25mcg/ed for a week. then taper up too no more then 100mcg/ed. just remember, you are manipulating your thyroid, so the less you can get away with the better. oh, and always taper back down before stopping.