Durabolin
(Nandrolone Phenylpropionate)
(Nandrolone Base + Phenylpropionate Ester)
Molecular Weight(base):274.4022
Molecular Weight (ester): 150.174
Formula (base): C18 H26 O2
Formula (ester): C9 H10 O2
Melting Point (base): 122-124°C
Melting Point (ester):
Manufacturer: Organon
Effective Dose (Men): 200-600mgs/week (2mg/lb of Bodyweight)
Effective Dose (Women): 50-100mgs/week
Active life:5 days.
Detection Time: Up to 12 months
Anabolic/Androgenic ratio: 37:125
Effective Dose (Men): 300-600mgs/week
Effective Dose (Women): 50-100mgs/week
Nandrolone is a modification of testosterone (carbon atom removed from the 19th position) With an Anabolic/Androgenic ratio: 37:125 it is highly anabolic (muscle building) and moderately androgenic (male characteristics). Due to nandrolones chemical structure is only aromatizes (convert to estrogen) slightly, at about 20% the rate of testosterone when it interacts with the aromatize enzyme. Thus estrogenic effects are not a major concern with its use. However nandrolone is also a progestin with a binding affinity of 20% to the receptor of the female sex hormone progesterone15 (PgR) though rare the development of breast tissue (gynecomastia) is reported in some steroid.com users. One of the most popular anabolic steroid used in bodybuilding cycles, nandrolone is used to treat severe debility or disease states and refractory anemias.1 It promotes tissue building processes, reverses catabolism (muscle destroying) and stimulates erythropoiesis (red blood cell production). Making it a useful drug to treat wasting disorders such as advanced H.I.V disese.2 16
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Nandrolone is most commonly found with a cypionate, laurate, decanoate or plenylpropionate ester. The ester determines how much of the given hormone is released over a period of time, longer esters such as the decanoate peak slowly and can keep stable blood plasma levels up to ten days (see above chart), shorter esters such as the phenylpropionate peak more rapidly but the half-live is shorter. (See chart). Shorter esters usually release much more active hormone per mg than longer esters. Surprisingly NPP (Durabolin) and ND (Deca) release almost the same amount of active nandrolone per 100mg with 69% and 65% respectively, this does not matter though because blood levels of nandrolone are much higher (about doubled) post NPP usage compared to the same 100mg dose of ND. (see chart) NPP also has more distinct advantages over ND. One of the most common complaints about adding ND (deca) to a cycle is the water retention that accompanies its use.3 Gains from NPP are reported to be “clean” with minimal water retention and fat gain. While ND is usually used in “bulking” cycles, NPP is used in “cutting” cycles although either drug can be used in this regard. Being an oil based anabolic it is injected intramuscularly (into the muscle), many users inject it ED or EOD, however NPP can administered E4D without problems. (See chart).
NPP and nandrolone in general has a number of benefits for athletes, it increases levels of serotonergic amines in the brain, these chemicals contribute to aggressive behavior, this could help athletes to train harder and improve speed and power.4 Nandrolone also increases levels of IGF-1 in muscle tissues.5 This may be another way that makes nandrolone highly anabolic. NPP also benefits the athlete by increasing the number of androgen receptors (AR) one study showed that nandrolone given to rats at a dosage of 6mg/kg of bodyweight combined with muscle functional overload (muscle functional overload gives a similar effect to resistance training) had a 1,300% (!) increase in AR concentrations.6 There is a direct link to muscle growth and AR levels. NPP also seems to be a promising fat loss agent, men given the drug had reduced levels of subcutaneous (under skin) adipose(fat) tissue, visceral (gut) fat loss was not as good however.7 The fat loss effect seems though to be dose dependant, in one study NPP at a daily dose of 1, 4, 10mg per kg of bodyweight the 10mg dose had the greatest effect on fat loss8 NPP is used to treat anemia by stimulating red blood cell production,1 an increase in RBC count can improve endurance during exercise via better lactic acid clearing and oxygen delivery. The blood is also better enabled to carry nutrients to muscle tissue to aid in repair, administration also increases the rate of muscle glycogen repletion after exercise helping the athlete dramatically improve recovery after strenuous physical exercise.9 Athletes who require a high level of endurance in their chosen sport can benefit from the use of NPP.15 A favorite with bodybuilders who suffer with sore joints, NPP can improve collagen synthesis 10. Many members of steroid.com swear by nandrolones ability to allow them to train in comfort.
Although many nandrolone lovers claim that it is one of the safest anabolic steroids, if not the safest. It does have side effects that can be bothersome in hypersensitive individuals, such as acne, excitation, insomnia, nausea, diarrhea and bladder irritability1. More serious side effects include testicular atrophy (shrunken balls), impotence (deca dick) and gynecomastia (bitch tits) 1. Nandrolone use has been shown to be safe and easy on the lipid profile16 Impotence can be offset by stacking the nandrolone with a higher dose of testosterone, nandrolone being a progestin causes the “shut down” of endogenous testosterone production. Thus an exogenous (outside) source must be provided, the increased prolactin levels from the use of a progestinic steroid contribute to HPTA shut down and testicular atrophy which can be treated with a combination HCG (female hormone that acts like LH when introduced into the male body) and bromocriptine (a dopamine receptor agonist that lowers prolatin levels.)1 11 Besides using bromcriptine to lower prolactin levels, the anti-estrogens fulvestrant or letrozole on be taken to downregulate the progesterone and estrogen receptor.12 13
NPP can be useful in either “bulking” or “cutting” cycles, it would seem that diet and dosages are the determine factors of which result the athlete will achieve. Due to its highly anabolic nature coupled with low androgenic properties it can be incorporated into a mass gain cycle, stacked with a testosterone ester and a powerful oral like oxymetholone or methandrostenolone and NPP is part of a classic bulking cycle. For a cutting cycle NPP can be combined with other short chain injectable anabolic steroids (testosterone propionate and boldenone acetate come to mind) and one of the DHT derived orals such as stanozolol (winstrol) or oxandrolone (anavar). NPP is said to produce good mass and strength gains in both cutting and bulking cycle phases3. When one is planning a cutting cycle one must take caution if combining the 19-nor-testosterone derivative trenbolone with nandrolone. Trenbolone although a powerful drug for lean muscle gains, strength and fat loss it is also a strong progestin with a binding affinity to the PgR of 60%. The elevated prolactin, would cause the worst HPTA insult, causing the user to spend more money on preventative measures, the combo may also result in a difficult PCT protocol to regain natural testosterone production. So far few steroid.com members have any on hand experience with NPP, only the few who know what UGLs sells this particular ester of nandrolone, with the increasing popularity of “home brewing” and the powder coming out of China at very affordable prices, it is only a matter of time that NPP or Durabolin takes a special place in the arsenal of steroid.com members in their quest for more muscle.
References:
1 Nursing2003 drug handbook.
2 Am J Physiol Endocrinol Metab. 2002 Dec; 283(6):E1214-22.
3 Steriod.com/steroid forums.
4 Med Sci Sports Exerc. 2003 Jan; 35(1):32-8.
5 Am J Physiol Endocrinol Metab. 2002 Feb; 282(2):E483-90
6 J Appl. Physiol.94 1153-61 2003
7 Int J Obes Relat Metab Disord. 1995 Sep; 19(9):614-24.
8 Ann Nutr Metab. 1991; 35(3):141-7.
9 J Vet Med A Physiol Pathol Clin Med. 2001 Aug; 48(6):343-52
10 Metabolism. 1990 Nov; 39(11):1167-9.)
11 Pharmacol Biochem Behav. 1988 Mar; 29(3):489-93.
12 Cancer Res. 2003 Oct 1; 63(19):6523-31.)
13 Expert Opin Pharmacother. 2004 Dec; 5(12):2549-58.
14 Cancer Res 1978 Nov; 38(11 Pt 2):4186-98
15 Med Sci Sports Exerc. 1995 Oct;27(10):1385-9.
16 Am J Physiol Endocrinol Metab. 2002 Dec;283(6):E1214-22. Epub 2002 Aug 27.
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