myostatin,will it make steroids obsolete?

[freakazoid]

been checking out this new chemical called myostatin.scientist recently discovered it.it regulates muscle growth and keeps muscles from getting to big.in cattle and mice,gene mutations sometimes knock out myostatin,which creates creatures that resemble olimpians of the animal kingdom,in a few years scientists should be able to turn offmyostatin in specific muscles,which will alow that muscle to grow at an increatable rate.scientists can already do this in animals and wont be long before the techniquewill be available for patients with muscle wasting diseases.and of course im sure it will find its way into bodybuilding

 

[Dirty Boy]

i would like a trial size sample please

 

[Test boy]

I'll try it.

 

[Willyumyum]

yeah, myostatin blockers, right? I think I Was reading about that in MD this month or last month or something... that will be SICK when it comes out...

YUM

 

[Dr.X]

It is highly doubtful that any myostatin inhibitors will be available for human use for at least 10 years (if ever). Antisense RNA therapy or RNAi are basically two applications of gene therapy that are way too novel to exploit.

 

[Willyumyum]

It is highly doubtful that any myostatin inhibitors will be available for human use for at least 10 years (if ever). Antisense RNA therapy or RNAi are basically two applications of gene therapy that are way too novel to exploit.

It would be something if they could get it done... I'll try and see if i can find that article on the myostatin inhibitors that i saw in MD...

YUM

 

[Willyumyum]

Alright, I found it in the magazine I have here... I'll take a few minute and type it up and post it in a new thread or something..

YUM

 

[GameBreaker]

first of all this is OLD news and second of all, it'll will be a long time before u can get it...and if u can get it then why bother? that means everyone will and noone will need to work out..we'll all look good and good will no longer be special...thirdly, it causes Uncontrolled growth in every type of muscle, not just the skeletal muscles u want to grow...

 

[trial0r]

i'll take two

 

[muscle-doc]

this is an example efects of Myostatin

Note: the gorw its see in all types of muscles, and for this, produce Cardiomegalic

 

[muscle-doc]

other

 

[muscle-doc]

This is the future of Myostatin???

LOL

the future its near now

 

[Willyumyum]

this is an example efects of Myostatin

Note: the gorw its see in all types of muscles, and for this, produce Cardiomegalic

holy cow

YUM

 

[painly]

holy cotex with whipped cream

 

[sicklydiesel]

damn..that third mouse has legs bigger than some of you guys.

 

[marky]

Problem as of yet is specifying or localizing the growth, it just keeps growing beyond where you want it. how bout great thighs with extendede monster butt

 

[jstrong20]

This is the future of Myostatin???
LOL
the future its near now

Hey where did you get a pic of me from?

 

[TieRex]

Myo-what, anyway if it will make me go faster, grow stronger and get generally bigger, well then;
eh, excuse me, I'll take three to go pls...

Yup...

 

[Bubba]

I've been reading about this as well. The pictures sure do give it a whole new perspective.

Thnx Doc

 

[Moe]

This is a letter that was sent out from a lab (named below) regarding Myostatin and elite bodybuiilders...

------------------------------------------------------------------------------------
October 1, 1998

Re: Flex Wheeler

To whom it may concern:

I am writing this letter per the request of Flex Wheeler.

I would first like to briefly provide you with some background information regarding BALCO Laboratories. BALCO has been working with elite Olympic and professional athletes for over fifteen years. BALCO has provided testing and consultation for over 250 NFL players including the entire 1998 Super Bowl Champion Denver Broncos team and the entire Miami Dolphins team. BALCO works with professional athletes in many sports including teenis (Michael Chang, Jim Courier, etc.), hockey, bodybuilding (10 of the 16 1998 Mr. Olympia contestants), track and field, soccer and basketball (Seattle SuperSonics).

BALCO Laboratories has been testing and monitoring Flex on a routine basis during the last year. We have performed tests including blood chemistry (SMAC), complete blood count (CBC), PSA, anabolic hormone levels, genotyping as well as comprehensive testing for nutritional elements. Flex's test results have been compared to twenty-four other professional bodybuilders and overall he has one of the healthiest profiles. Basically, Flex is in excellent health and has demonstrated the discipline necessary to maintain a peak level of conditioning.

Flex was a participant in a study we recently conducted in collaboration with the Department of Human Genetics at the University of Pittsburgh involving 62 men who made unusually large gains in muscle mass in response to strength training (extreme responders). Flex was one of only nine extreme responders that had the very rare "myostatin mutation." Myostatin is the gene that "limits muscle growth." Specifically, Flex had the rarest form of myostatin mutation at the "exon 2" position on the gene. This simply means Flex has a much larger number of muscle fibers compared to the other subjects or the normal population. We believe that these are the very first myostatin mutation findings in humans and the results of this landmark study have already been submitted for publication. Flex was also found to have a very unusual type of the IGF-1 gene. In fact, Flex was the only participant in the study that did not have a "match." All of the other extreme responders had at least three other subjects with a matching IGF-1 gene. Based upon Flex's very unique genetic profile, we plan to expeditiously publish a scientific paper that reveals his complete genotype in specific detail. The publication of his remarkable genetic data should generate an enormous amount of media exposure.

Hope this information will be helpful and please call if I can be of assistance.

Sincerely,

/s/ Victor Conte

Victor Conte
President
BALCO Laboratories, Inc.




1520 Gilbreth Road • Burlingame, CA 94010 • 1-800-777-7122 • FAX (650) 687-6576

------------------------------------------------------------------------------------

And you thought Flex just had great genetics and took a lot of drugs. Hell ,it turns out he is an honest-to-goodness mutant--pretty cool!

 

[sicklydiesel]

Flex is a freak. Lucky son of a bitch!

 

[69Muscle]

Where's ** with a Myostatin gene blocker!?!?!?


Hop to it China man!

 

[Enigmaxxx7]

Where's ** with a Myostatin gene blocker!?!?!?


Hop to it China man!

 

[69Muscle]

A good read about it:

Super Cows and Mighty Mice

In 1997, scientists McPherron and Lee revealed to the public the ‘secret’ of an anomaly that livestock breeders have capitalized since the late 1800’s: the gene responsible for big beefy cows (1). More than a century ago, livestock breeders in Europe observed that some of their cattle were more muscled than others. Being dabblers in genetics, they selectively bred these cattle to increase the progeny displaying this trait. Thus two breeds of cattle (Belgian Blue and Piedmontese) were developed that typically exhibit an increase in muscle mass relative to other conventional cattle breeds. Little did they know that many years later Mighty Mouse would be more than merely a cartoon.

A team of scientists led by McPherron and Lee at John Hopkins University was investigating a group of proteins that regulate cell growth and differentiation. During their investigations they discovered the gene that may be responsible for the phenomenon of increased muscle mass, also called ‘double-muscling’ (1, 2). Myostatin, the protein that the gene encodes, is a member of a superfamily of related molecules called transforming growth factors beta (TGF-b ). It is also referred to as growth and differentiation factor-8 (GDF-8). By knocking out the gene for myostatin in mice, they were able to show that the transgenic mice developed two to three times more muscle than mice that contained the same gene intact. Lee commented that the myostatin gene knockout mice "look like Schwarzenegger mice." (3).

Further exploration of genes present in skeletal muscle in the two breeds of double-muscled cattle revealed mutations in the gene that codes for myostatin. The double-muscling trait of the myostatin gene knockout mice and the double-muscled cattle demonstrates that myostatin performs the same biological function in these two species. Apparently, myostatin may inhibit the growth of skeletal muscle. Knocking out the gene in transgenic mice or mutations in the gene such as in the double-muscled cattle result in larger muscle mass. This discovery has paved the way for a plethora of futuristic implications from breeding super-muscled livestock to treatment of human muscle wasting diseases.

Researchers are developing methods to interfere with expression and function of myostatin and its gene to produce commercial livestock that have more muscle mass and less fat content. Myostatin inhibitors may be developed to treat muscle wasting in human disorders such as muscular dystrophy. However, several public media sources immediately raised the issue of abusing myostatin inhibitors by athletes. In addition, a hypothesis has been put forth that a genetic propensity for high levels of myostatin is responsible for the lack of muscle gain in weight trainees. Accordingly, this article presents a look at the science of myostatin and its implications for the athletic arena.

 

[muscle-doc]

Nice info 69Muscle
a + Karma 4 u