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MohawkMuscle
Guest
Is What are your votes?
M.d.
Should we really trust this new supplement? Supposedly it blocks the myostatin in your body, so in theory that if it blocks the myostatin then once will grow muscle. If it does what the label claims and does block myostatin, what implications will this have on the body and its functions? Will the heart grow to an unhealthy size, will the inhibited myostatin cause cell duplication to go out of control, and what if it causes already mutated cells “cancer” to replicate much faster then is natural? Anyone out there a M.D. and could answer some of these questions.
Should we really trust this new supplement? Supposedly it blocks the myostatin in your body, so in theory that if it blocks the myostatin then once will grow muscle. If it does what the label claims and does block myostatin, what implications will this have on the body and its functions? Will the heart grow to an unhealthy size, will the inhibited myostatin cause cell duplication to go out of control, and what if it causes already mutated cells “cancer” to replicate much faster then is natural? Anyone out there a M.D. and could answer some of these questions.
riskybizz007
New member
Very good questions you raise... bumpin for info.
I'll pass and wait.....
Still, a recent study did indicate that there is a role for myostatin in adult humans; in fact, their conclusion reads, "...the detection of myostatin in post-natal skeletal muscle, combined with studies of humans with wasting diseases, provide strong circumstantial evidence for the role of myostatin in regulating muscle growth after birth, and future studies will be crucial in the further understanding of myostatin." But make no mistake, the supplement Cytoseira canariensis suggested to cause myostatin inhibition lacks any human research. So although there's definite evidence that myostatin has a powerful impact on muscle growth in humans, there's no evidence that we can, as of yet, take advantage of that knowledge.
Still, a recent study did indicate that there is a role for myostatin in adult humans; in fact, their conclusion reads, "...the detection of myostatin in post-natal skeletal muscle, combined with studies of humans with wasting diseases, provide strong circumstantial evidence for the role of myostatin in regulating muscle growth after birth, and future studies will be crucial in the further understanding of myostatin." But make no mistake, the supplement Cytoseira canariensis suggested to cause myostatin inhibition lacks any human research. So although there's definite evidence that myostatin has a powerful impact on muscle growth in humans, there's no evidence that we can, as of yet, take advantage of that knowledge.
edgecrusher
New member
If we did have something powerful enough to take advantage of the myostatin gene, it would not be sold OTC.
riskybizz007
New member
Thing is most of the non-OTC's today once were sold over the counter. Still I'm wondering if this product would work at all, I've seen more and more ads on it and not only Biotest makes it now. Guess we have to wait to see who will try it 1st around here. 
serge
New member
Myostatin
by Grendel
The Bull stands there, confident, powerful, in control of himself and his situation. He is the master of his domain and all he surveys. His powerful muscles ripple beneath paper-thin skin; there is almost no fat on his body. He swaggered over to a heifer and she flicks her ears seductively. Yes, it's good to a Belgian blue. That money he spent on his Charles Atlas program was well worth it, he reflects. In America, first you get the muscles, and then you get the women.
I am sure many of you have seen pictures of the Belgian Blue cow similar to the one above, the so-called "double muscled cow." This cow has an incredible amount of muscle tissue and is the result of selective breeding. The magic behind this cow is the myostatin gene[1] [2] which, when "knocked out" permits the muscles of the cow to grow unchecked. The early influence of the myostatin gene was seen in mice as early as 1987[3]. Myostatin is part of the super-family of growth factors; these genes encode for secreted chemicals that regulate, in humans, embryonic development and tissue homeostasis (in adults). While myostatin plays a huge role in embryo development, it still has an impact on developed skeletal muscle. Myostatin controls not only fiber size but also fiber number; think of this as controlling, for our purposes, both size and strength. Interestingly enough, muscle tissue in mice that have been exercised shows an increase in myostatin[4] levels while the muscle of mice during recovery shows a decrease in myostatin levels[5].
It does not take an advanced degree in biology to see that being able to control the expression of the myostatin gene would be a tremendous breakthrough. And, for bodybuilders, the ability to control myostatin levels would permit unprecedented muscular development. Now the problem is that many times what works in animals will not work in humans; this is the case with adrenal stimulants like clenbuterol that produce muscle growth in cattle but not humans because we lack one type of adrenal receptor.
Therefore, just because we can have extremely muscular mice or cows, does that mean we can do the same to humans?
Fortunately, humans do have a myostatin gene, but the question still remains, will a mutation, limitation, or alternation of this gene have any impact on human muscular development? Some research has allegedly been done on Flex Wheeler, a top-level professional bodybuilder, by BALCO Laboratories, Inc. The research, according to a statement available on the Internet, indicated that Mr. Wheeler "Was a participant in a study we recently conducted in collaboration with the Department of Human Genetics at the University of Pittsburgh involving 62 men who made unusually large gains in muscle mass in response to strength training (extreme responders). Flex was one of only nine extreme responders that had the very rare "myostatin mutation." Myostatin is the gene that "limits muscle growth." Specifically, Flex had the rarest form of myostatin mutation at the "exon 2" position on the gene. This simply means Flex has a much larger number of muscle fibers compared to the other subjects or the normal population. We believe that these are the very first myostatin mutation findings in humans and the results of this
landmark study have already been submitted for publication."
Taking all this information in can be overwhelming. It sounds almost like science fiction, doesn't it? But then again, if you look in the context of the gym, there has always been a clear line of people who possesses what was simply called "great genetics." In addition to naturally higher hormone levels, it appears likely that these people have other genetic anomalies, which explain their superior physiques (caveat: of course training is crucial, but we all have that friend who is naturally big and ripped without much effort while we slave away). Myostatin appears to be one of the usual suspects; the lower the levels of myostatin expression in a person, the bigger their muscle can get (put simply).
So let run out and stop our myostatin gene from being expressed. Oh, wait.You would have to alter your genetic code and that would take genetic engineering wouldn't it? Sorry, but we are just not at the point where we can casually snip out segments of DNA; if we were, we would have eradicated many diseases and conditions that have plagued mankind for centuries. Research is underway, of course. If you want to help, BioVendor
Laboratories has your human myostatin research kit (or will have it soon). See if you can't unravel the mystery that is facing the top geneticists in the world during "Who Wants to Be A Millionare."
Why am I being so flippant when I speak of the difficulty involved in turning the information we have on myostatin into something applicable for humans? I am being so sarcastic because supplement companies are now claiming to have been able to develop a product, available over-the-counter for an ungodly price, that will manipulate myostatin. Fortunately, these companies do not yet have the audacity to claim that their pill can alter
your genetic code, one company which intends to release a myostatin inhibiting product acknowledges that this would, at this point, involve really only selective breeding which is only a viable option for animals (unless we travel back to Germany during the 1940s)
So what is the rationale behind this new line of products that will be coming soon to a store near you? The line these companies are advancing has to do with the distinction between the myostatin gene and the proteins the gene codes for. The proteins run around the body and stop the production of new muscle cells (in adults). While these supplement
companies are keeping silent on how their product will work, I am sure that is has to do with these proteins and somehow neutralizing them. Sounds pretty impressive for a supplement company, even ones with millions and millions of dollars (cough choke gasp) to spend on research and development considering that no major international pharmaceutical company (say, Roche or Upjohn) or major University (Johns Hopkins) has come close to doing this. I am waiting for a supplement company to cure AIDS, screw this doctor stuff, let's get the presidents of the supplement companies together
and put them in charge of curing epidemics like AIDS and cancer.
What is even more miraculous is that, in order for this product to be sold as a supplement, it will come from a food source otherwise, guess what, it's a drug and you have to get this little thing called FDA approval (but whose looking anyway, right). The one company that does have a product like this out uses a "marine plant extract" called Cystoseira canariensis. Do I need to say anything more? This algae has been available in nutritional supplements for a long time and for a lot less than these new myostatin "inhibitors".
The bottom line is that the very idea of this supplement line is ludicrousto me. I might be able to believe that, in a few years, a major pharmaceutical company will come out with a product that might, in some way, achieve this claim. Even if this were possible, would it be safe? While the supplement companies will, of course, claim that there are no
adverse side effects from their myostatin inhibitor, does that seem logical
>to anyone? Here is a new product which effects an entire class of protein intimately involved in muscle growth, regeneration, and regulation. This product can produce tremendous muscle gains (or whatever the claim is) but without side effects. Sure.
I hate to be "that guy" but hopefully I can cause anyone considering these over-priced sea animal products to reconsider. Remember the 1980s? Remember, oh, OKG or plant sterols? Well, this is the second coming of that degree of marketing hype. There are no independent studies showing any impact of any drug, let alone marine extract, on human myostatin or the proteins coded for by the myostatin gene. I am eagerly waiting to see what studies are alleged to back these new product claims and what species they were performed in University of Central Afghanistan, Extracts from Sea Creatures make Star Fish, Flounders, and Snakes big as HELL AND RIPPED TO due to inhibition of myostatin encoded protein.
by Grendel
The Bull stands there, confident, powerful, in control of himself and his situation. He is the master of his domain and all he surveys. His powerful muscles ripple beneath paper-thin skin; there is almost no fat on his body. He swaggered over to a heifer and she flicks her ears seductively. Yes, it's good to a Belgian blue. That money he spent on his Charles Atlas program was well worth it, he reflects. In America, first you get the muscles, and then you get the women.
I am sure many of you have seen pictures of the Belgian Blue cow similar to the one above, the so-called "double muscled cow." This cow has an incredible amount of muscle tissue and is the result of selective breeding. The magic behind this cow is the myostatin gene[1] [2] which, when "knocked out" permits the muscles of the cow to grow unchecked. The early influence of the myostatin gene was seen in mice as early as 1987[3]. Myostatin is part of the super-family of growth factors; these genes encode for secreted chemicals that regulate, in humans, embryonic development and tissue homeostasis (in adults). While myostatin plays a huge role in embryo development, it still has an impact on developed skeletal muscle. Myostatin controls not only fiber size but also fiber number; think of this as controlling, for our purposes, both size and strength. Interestingly enough, muscle tissue in mice that have been exercised shows an increase in myostatin[4] levels while the muscle of mice during recovery shows a decrease in myostatin levels[5].
It does not take an advanced degree in biology to see that being able to control the expression of the myostatin gene would be a tremendous breakthrough. And, for bodybuilders, the ability to control myostatin levels would permit unprecedented muscular development. Now the problem is that many times what works in animals will not work in humans; this is the case with adrenal stimulants like clenbuterol that produce muscle growth in cattle but not humans because we lack one type of adrenal receptor.
Therefore, just because we can have extremely muscular mice or cows, does that mean we can do the same to humans?
Fortunately, humans do have a myostatin gene, but the question still remains, will a mutation, limitation, or alternation of this gene have any impact on human muscular development? Some research has allegedly been done on Flex Wheeler, a top-level professional bodybuilder, by BALCO Laboratories, Inc. The research, according to a statement available on the Internet, indicated that Mr. Wheeler "Was a participant in a study we recently conducted in collaboration with the Department of Human Genetics at the University of Pittsburgh involving 62 men who made unusually large gains in muscle mass in response to strength training (extreme responders). Flex was one of only nine extreme responders that had the very rare "myostatin mutation." Myostatin is the gene that "limits muscle growth." Specifically, Flex had the rarest form of myostatin mutation at the "exon 2" position on the gene. This simply means Flex has a much larger number of muscle fibers compared to the other subjects or the normal population. We believe that these are the very first myostatin mutation findings in humans and the results of this
landmark study have already been submitted for publication."
Taking all this information in can be overwhelming. It sounds almost like science fiction, doesn't it? But then again, if you look in the context of the gym, there has always been a clear line of people who possesses what was simply called "great genetics." In addition to naturally higher hormone levels, it appears likely that these people have other genetic anomalies, which explain their superior physiques (caveat: of course training is crucial, but we all have that friend who is naturally big and ripped without much effort while we slave away). Myostatin appears to be one of the usual suspects; the lower the levels of myostatin expression in a person, the bigger their muscle can get (put simply).
So let run out and stop our myostatin gene from being expressed. Oh, wait.You would have to alter your genetic code and that would take genetic engineering wouldn't it? Sorry, but we are just not at the point where we can casually snip out segments of DNA; if we were, we would have eradicated many diseases and conditions that have plagued mankind for centuries. Research is underway, of course. If you want to help, BioVendor
Laboratories has your human myostatin research kit (or will have it soon). See if you can't unravel the mystery that is facing the top geneticists in the world during "Who Wants to Be A Millionare."
Why am I being so flippant when I speak of the difficulty involved in turning the information we have on myostatin into something applicable for humans? I am being so sarcastic because supplement companies are now claiming to have been able to develop a product, available over-the-counter for an ungodly price, that will manipulate myostatin. Fortunately, these companies do not yet have the audacity to claim that their pill can alter
your genetic code, one company which intends to release a myostatin inhibiting product acknowledges that this would, at this point, involve really only selective breeding which is only a viable option for animals (unless we travel back to Germany during the 1940s)
So what is the rationale behind this new line of products that will be coming soon to a store near you? The line these companies are advancing has to do with the distinction between the myostatin gene and the proteins the gene codes for. The proteins run around the body and stop the production of new muscle cells (in adults). While these supplement
companies are keeping silent on how their product will work, I am sure that is has to do with these proteins and somehow neutralizing them. Sounds pretty impressive for a supplement company, even ones with millions and millions of dollars (cough choke gasp) to spend on research and development considering that no major international pharmaceutical company (say, Roche or Upjohn) or major University (Johns Hopkins) has come close to doing this. I am waiting for a supplement company to cure AIDS, screw this doctor stuff, let's get the presidents of the supplement companies together
and put them in charge of curing epidemics like AIDS and cancer.
What is even more miraculous is that, in order for this product to be sold as a supplement, it will come from a food source otherwise, guess what, it's a drug and you have to get this little thing called FDA approval (but whose looking anyway, right). The one company that does have a product like this out uses a "marine plant extract" called Cystoseira canariensis. Do I need to say anything more? This algae has been available in nutritional supplements for a long time and for a lot less than these new myostatin "inhibitors".
The bottom line is that the very idea of this supplement line is ludicrousto me. I might be able to believe that, in a few years, a major pharmaceutical company will come out with a product that might, in some way, achieve this claim. Even if this were possible, would it be safe? While the supplement companies will, of course, claim that there are no
adverse side effects from their myostatin inhibitor, does that seem logical
>to anyone? Here is a new product which effects an entire class of protein intimately involved in muscle growth, regeneration, and regulation. This product can produce tremendous muscle gains (or whatever the claim is) but without side effects. Sure.
I hate to be "that guy" but hopefully I can cause anyone considering these over-priced sea animal products to reconsider. Remember the 1980s? Remember, oh, OKG or plant sterols? Well, this is the second coming of that degree of marketing hype. There are no independent studies showing any impact of any drug, let alone marine extract, on human myostatin or the proteins coded for by the myostatin gene. I am eagerly waiting to see what studies are alleged to back these new product claims and what species they were performed in University of Central Afghanistan, Extracts from Sea Creatures make Star Fish, Flounders, and Snakes big as HELL AND RIPPED TO due to inhibition of myostatin encoded protein.
serge said:
I would venture a guess that that article is copyrighted.
You should post an excerpt and then provide a link to the full article at www.anabolicextreme.com -- where the article is from.
