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HighIntensity
Guest
or another member tell me more about LPC~
H
HighIntensity
Guest
show me your legs again 
MrMuscle
New member
LPC is being touted as a great and nifty way to increase absorption of various supplements (most notably, prohormones and glutamine) in the gastrointestinal tract. Industry pariah Patrick Arnold first introduced LPC when he was making up prohormone formulations for a company called OSMO. Dan Duchaine was the next industry expert to jump on the LPC bandwagon.
There's also a product (Plasmogen) that is basically encapsulated, pure LPC. Mass Quantities (www.massquantities.com) brags about how they incorporate LPC into their supplements (this statement is highlighted at their website÷they're actually proud of it). Excuse me, but did any of these folks (and the many others promoting LPC) give the substance ANY due diligence regarding its safety? Or maybe they just don't give a damn and figure you, the consumer, are too stupid to research what you're putting into your body?
LPC is a naturally occurring compound found in the human digestive tract (it's found in human bile in the small intestines). LPC interferes with calcium ion exchange [Ca2+i] at the cell membrane and basically makes cells more "porous." The idea is that if you use exogenous LPC orally, the "little holes" that it punches in the cells that line your stomach will allow for prohormones/supplements to be absorbed in the stomach rather than just in the intestines. This makes LPC an interesting drug delivery system. The supplement, be it glutamine or a prohormone, can fall through these "little punched out holes" and thereby go directly into the bloodstream. Fair enough, the idea's quite sound and I have no quarrel with that train of logic. I bet it works to a certain degree. But LPC has some pretty serious potential side effects. I can't remember the last time I have seen a "non-drug" unregulated compound with such potential to do such real damage to the user.
Since I make mention that LPC is being used as a drug delivery system by punching holes in the cells of the stomach, I'll start by discussing the potential side effects of LPC in the gastrointestinal tract. LPC has been implicated in numerous studies as a causative agent of duodenal ulcers. In studies at King's College Department of Pharmacy in London and The Netherlands's Institute for Dairy Research's Department of Nutrition in the Netherlands, LPC has directly been implicated in causing gastritis and colon cancer by damaging colonic mucosa and consequently increasing epithelial cell proliferation.1,2 It would seem patently obvious to even the most doltish of people that something that "punches little holes" in your stomach could easily cause ulcers.
Think for a minute·what is an ulcer? It's a lesion (or little hole). When placed in tap water and fed to rats, LPC demonstrated an astounding increase in ulcer rate when compared to rats that just drank regular tap water.3 Additionally, the lower the pH, the more active LPC is inducing ulcerative changes in tissues.4 The pH of your stomach is pretty low at around 2-3. LPC also happens to have maximal or close to maximal "hole punching" activity at 37?C5,which just happens to be normal human body temperature. So, after you gulp down a few capsules of your favorite LPC-laced supplement every day for a few months and possibly fry holes in your gut, what happens next? Glad you asked.
It would appear that LPC is readily absorbed into the bloodstream through the colon.6 Once LPC is in your blood, the real fun stuff starts. LPC basically causes red blood cells to explode like little red hand grenades. In one study, human red blood cells were treated with LPC at 37?C. LPC was rapidly incorporated into the red blood cells and induced crenation (Echinocyte formation) type [crenation means "indented," or the shape of a shriveled red blood cell]. The amount of crenation was dependent on the amount of LPC present.7 So what the heck is an Echinocyte? Echnocytes are badly misshapened red blood cells that don't carry oxygen very well and can cause micro-emboli as they tend to clog up capillaries all over the body (keep thinking about strokes). Echinocytes are seen often in people who have Sickle Cell Anemia, a crippling genetic disorder that affects primarily African Americans.
Having some Echinoctyic red blood cells might be really useful for preventing infection with Plasmodium vivax, which is one of four "plasmodiae" that are the causative agents of malaria. The dysmorphic shape of Echinocytes makes it hard for these parasites to reproduce efficiently, so if you're romping around the jungles of Zaire or Kenya poaching elephants, Echinocytic red blood cells might come in handy. However, if you're in the US of A (or any other non-Third World country), Echinocytes are a real drag. You see, aside from clogging up small blood vessels and possibly causing strokes, excessive Echinocyte formation puts a fair stress on the spleen (which removes these damaged red blood cells from circulation). Therefore, it's logical to conclude that an excessive amount of LPC will cause an excessive amount of red blood cell crenation. This can lead to splenomegaly (enlarged spleen). Ouchie!!!
Keep in mind, too, that red blood cells have "stuff" in them even if they don't have a nucleus, per se. What "stuff?" Biochemicals like hemosiderin and transferrin and porphyran. Stuff that your kidneys don't really like to deal with in high quantities. Excessively high plasma levels of the aforementioned "stuff" will lead to permanent renal impairment. Now I'll admit readily that albumin, the most abundant type of "protein" found in your blood, will bind with and inhibit the nasty action of LPC. Trouble is, just how much LPC your albumin can deal with at any given time is, well·unknown. Maybe 100 mg? 200 mg? 500 mg? Do you really want to be the one who has to figure it out?
If LPC is in your blood stream and it's not bound to albumin, it can do some truly nasty things to your arteries. We all have this type of white blood cell called a "monocyte," and monocytic cell invasion into the blood vessel wall is a very important step in the development of atherosclerotic lesions. Obviously, it's not something you want. At the Chiba University School of Medicine in Japan, at least one study demonstrated that LPC vastly increases the cellular adhesion of monocytes to the walls of blood vessels.8
Arteries are also lined with smooth muscle, allowing for arterial dilation/constriction in order to regulate blood pressure. One study conducted at the Karolinska Hospital's Department of Medicine in Sweden showed that LPC caused complete cell death (apoptosis) of human smooth muscle cells in a concentration as low as 25 umol/L.9 This stuff has the potential to do some real damage to your cardiovascular system, and I haven't even discussed the effect of LPC on your heart yet.
It's well known that LPC is an arrhythmogenic substance. Recent studies have demonstrated that LPC produces mechanical and metabolic derangement in the heart and [Ca2+i] overload in isolated cardiac myocytes. At the Asahikawa Medical College in Japan, two separate studies demonstrated that LPC causes an ischemia-like effect on the heart.10,11 If that isn't bad enough, it appears that a little LPC goes a long way, as LPC accumulates in the myocardium. There, it activates a compound called phospholipase A which, in turn, produces more LPC, establishing a vicious circle; i.e. LPC has the ability to produce more LPC in an ongoing cascade.
So far, our "cool supplement" has eaten through your gastrointestinal tract, possibly done some heavy damage to your spleen, red blood cells, blood vessels, and your heart. But we aren't done yet. LPC may also wreak havoc on your central nervous system. If we look upon the nervous system as "the electrical system of the human body," we see that we have "human wiring," so to speak, as nerves are roughly analogous to the wires in any electrical system. Much like these wires in an electrical system, your nerves have an insulating coating called "myelin." Copper electrical wire doesn't work well when you remove the plastic insulating sheath around it. Removing the sheath causes the copper wire to easily "short out" if it comes into contact with something else. Human nerve cells don't work well when you remove the myelin-insulating sheath around them, either. When nerve cells "demyelinate," multiple sclerosis or a condition very similar to it rapidly develops. When scientists want to study multiple sclerosis, an extremely debilitating neurodegenerative disease, they can induce a multiple sclerosis-like syndrome in primates by giving them LPC. That's correct, if you want to study the demyelination effect of multiple sclerosis in vivo with a "human model" (a primate), you inject a monkey with LPC.12 LPC "punches holes" through myelin, too.
Increased plasma levels of LPC have also been implicated in certain types of ovarian cancers (a good enough reason for every woman to stay away from it). I should say, however, that LPC does do some good things, too. Scientists are investigating LPC as a chemotherapeutic agent to treat certain types of drug-resistant leukemias.
This entire article has been a lesson in extremes, for sure. Plenty of people have ingested supplements that contain LPC and, quite obviously, they're not dead; they didn't have heart attacks; they didn't develop duodenal ulcers; nor did they develop a multiple sclerosis-type syndrome. Regardless, the fact remains that any or all of these side effects are possible. How much LPC will it take to cause some of these or all of these side effects? I don't know, and nobody does for sure. How long would you have to take LPC for some of these or all of these side effects to happen? Once again, I really don't know, and I won't pretend that I do. Basically, nobody knows, and only psychics and psychotics can "really" know the future ahead of time. But what I do know is that I'll never know first-hand if any or all of these things can or do happen, because I will never consume a supplement that contains LPC.
I'm more than willing to let someone else experiment with LPC, especially if you're one of those who blasted me for saying you "need the FDA to protect you." At least now you can make somewhat of an informed choice if you use a supplement laced with LPC.
Think about it. How many of you had half a clue that LPC can potentially cause some or all of the nasty side effects I made mention of in this article? Be honest. Do the people who sell LPC-laced supplements tell you all these facts? Do they even know about any of this? LPC is a time bomb in a capsule. Don't let it go off in your body.
*burp*
There's also a product (Plasmogen) that is basically encapsulated, pure LPC. Mass Quantities (www.massquantities.com) brags about how they incorporate LPC into their supplements (this statement is highlighted at their website÷they're actually proud of it). Excuse me, but did any of these folks (and the many others promoting LPC) give the substance ANY due diligence regarding its safety? Or maybe they just don't give a damn and figure you, the consumer, are too stupid to research what you're putting into your body?
LPC is a naturally occurring compound found in the human digestive tract (it's found in human bile in the small intestines). LPC interferes with calcium ion exchange [Ca2+i] at the cell membrane and basically makes cells more "porous." The idea is that if you use exogenous LPC orally, the "little holes" that it punches in the cells that line your stomach will allow for prohormones/supplements to be absorbed in the stomach rather than just in the intestines. This makes LPC an interesting drug delivery system. The supplement, be it glutamine or a prohormone, can fall through these "little punched out holes" and thereby go directly into the bloodstream. Fair enough, the idea's quite sound and I have no quarrel with that train of logic. I bet it works to a certain degree. But LPC has some pretty serious potential side effects. I can't remember the last time I have seen a "non-drug" unregulated compound with such potential to do such real damage to the user.
Since I make mention that LPC is being used as a drug delivery system by punching holes in the cells of the stomach, I'll start by discussing the potential side effects of LPC in the gastrointestinal tract. LPC has been implicated in numerous studies as a causative agent of duodenal ulcers. In studies at King's College Department of Pharmacy in London and The Netherlands's Institute for Dairy Research's Department of Nutrition in the Netherlands, LPC has directly been implicated in causing gastritis and colon cancer by damaging colonic mucosa and consequently increasing epithelial cell proliferation.1,2 It would seem patently obvious to even the most doltish of people that something that "punches little holes" in your stomach could easily cause ulcers.
Think for a minute·what is an ulcer? It's a lesion (or little hole). When placed in tap water and fed to rats, LPC demonstrated an astounding increase in ulcer rate when compared to rats that just drank regular tap water.3 Additionally, the lower the pH, the more active LPC is inducing ulcerative changes in tissues.4 The pH of your stomach is pretty low at around 2-3. LPC also happens to have maximal or close to maximal "hole punching" activity at 37?C5,which just happens to be normal human body temperature. So, after you gulp down a few capsules of your favorite LPC-laced supplement every day for a few months and possibly fry holes in your gut, what happens next? Glad you asked.
It would appear that LPC is readily absorbed into the bloodstream through the colon.6 Once LPC is in your blood, the real fun stuff starts. LPC basically causes red blood cells to explode like little red hand grenades. In one study, human red blood cells were treated with LPC at 37?C. LPC was rapidly incorporated into the red blood cells and induced crenation (Echinocyte formation) type [crenation means "indented," or the shape of a shriveled red blood cell]. The amount of crenation was dependent on the amount of LPC present.7 So what the heck is an Echinocyte? Echnocytes are badly misshapened red blood cells that don't carry oxygen very well and can cause micro-emboli as they tend to clog up capillaries all over the body (keep thinking about strokes). Echinocytes are seen often in people who have Sickle Cell Anemia, a crippling genetic disorder that affects primarily African Americans.
Having some Echinoctyic red blood cells might be really useful for preventing infection with Plasmodium vivax, which is one of four "plasmodiae" that are the causative agents of malaria. The dysmorphic shape of Echinocytes makes it hard for these parasites to reproduce efficiently, so if you're romping around the jungles of Zaire or Kenya poaching elephants, Echinocytic red blood cells might come in handy. However, if you're in the US of A (or any other non-Third World country), Echinocytes are a real drag. You see, aside from clogging up small blood vessels and possibly causing strokes, excessive Echinocyte formation puts a fair stress on the spleen (which removes these damaged red blood cells from circulation). Therefore, it's logical to conclude that an excessive amount of LPC will cause an excessive amount of red blood cell crenation. This can lead to splenomegaly (enlarged spleen). Ouchie!!!
Keep in mind, too, that red blood cells have "stuff" in them even if they don't have a nucleus, per se. What "stuff?" Biochemicals like hemosiderin and transferrin and porphyran. Stuff that your kidneys don't really like to deal with in high quantities. Excessively high plasma levels of the aforementioned "stuff" will lead to permanent renal impairment. Now I'll admit readily that albumin, the most abundant type of "protein" found in your blood, will bind with and inhibit the nasty action of LPC. Trouble is, just how much LPC your albumin can deal with at any given time is, well·unknown. Maybe 100 mg? 200 mg? 500 mg? Do you really want to be the one who has to figure it out?
If LPC is in your blood stream and it's not bound to albumin, it can do some truly nasty things to your arteries. We all have this type of white blood cell called a "monocyte," and monocytic cell invasion into the blood vessel wall is a very important step in the development of atherosclerotic lesions. Obviously, it's not something you want. At the Chiba University School of Medicine in Japan, at least one study demonstrated that LPC vastly increases the cellular adhesion of monocytes to the walls of blood vessels.8
Arteries are also lined with smooth muscle, allowing for arterial dilation/constriction in order to regulate blood pressure. One study conducted at the Karolinska Hospital's Department of Medicine in Sweden showed that LPC caused complete cell death (apoptosis) of human smooth muscle cells in a concentration as low as 25 umol/L.9 This stuff has the potential to do some real damage to your cardiovascular system, and I haven't even discussed the effect of LPC on your heart yet.
It's well known that LPC is an arrhythmogenic substance. Recent studies have demonstrated that LPC produces mechanical and metabolic derangement in the heart and [Ca2+i] overload in isolated cardiac myocytes. At the Asahikawa Medical College in Japan, two separate studies demonstrated that LPC causes an ischemia-like effect on the heart.10,11 If that isn't bad enough, it appears that a little LPC goes a long way, as LPC accumulates in the myocardium. There, it activates a compound called phospholipase A which, in turn, produces more LPC, establishing a vicious circle; i.e. LPC has the ability to produce more LPC in an ongoing cascade.
So far, our "cool supplement" has eaten through your gastrointestinal tract, possibly done some heavy damage to your spleen, red blood cells, blood vessels, and your heart. But we aren't done yet. LPC may also wreak havoc on your central nervous system. If we look upon the nervous system as "the electrical system of the human body," we see that we have "human wiring," so to speak, as nerves are roughly analogous to the wires in any electrical system. Much like these wires in an electrical system, your nerves have an insulating coating called "myelin." Copper electrical wire doesn't work well when you remove the plastic insulating sheath around it. Removing the sheath causes the copper wire to easily "short out" if it comes into contact with something else. Human nerve cells don't work well when you remove the myelin-insulating sheath around them, either. When nerve cells "demyelinate," multiple sclerosis or a condition very similar to it rapidly develops. When scientists want to study multiple sclerosis, an extremely debilitating neurodegenerative disease, they can induce a multiple sclerosis-like syndrome in primates by giving them LPC. That's correct, if you want to study the demyelination effect of multiple sclerosis in vivo with a "human model" (a primate), you inject a monkey with LPC.12 LPC "punches holes" through myelin, too.
Increased plasma levels of LPC have also been implicated in certain types of ovarian cancers (a good enough reason for every woman to stay away from it). I should say, however, that LPC does do some good things, too. Scientists are investigating LPC as a chemotherapeutic agent to treat certain types of drug-resistant leukemias.
This entire article has been a lesson in extremes, for sure. Plenty of people have ingested supplements that contain LPC and, quite obviously, they're not dead; they didn't have heart attacks; they didn't develop duodenal ulcers; nor did they develop a multiple sclerosis-type syndrome. Regardless, the fact remains that any or all of these side effects are possible. How much LPC will it take to cause some of these or all of these side effects? I don't know, and nobody does for sure. How long would you have to take LPC for some of these or all of these side effects to happen? Once again, I really don't know, and I won't pretend that I do. Basically, nobody knows, and only psychics and psychotics can "really" know the future ahead of time. But what I do know is that I'll never know first-hand if any or all of these things can or do happen, because I will never consume a supplement that contains LPC.
I'm more than willing to let someone else experiment with LPC, especially if you're one of those who blasted me for saying you "need the FDA to protect you." At least now you can make somewhat of an informed choice if you use a supplement laced with LPC.
Think about it. How many of you had half a clue that LPC can potentially cause some or all of the nasty side effects I made mention of in this article? Be honest. Do the people who sell LPC-laced supplements tell you all these facts? Do they even know about any of this? LPC is a time bomb in a capsule. Don't let it go off in your body.
*burp*
H
HighIntensity
Guest
ok, i might not be buying that now
thanks
thanks
PsychoSkitz
New member
And creatine causes cancer 
That appears to be a competitor bash, considering I just checked out the MQ site and the only product that has LPC in it IS LPC.
That appears to be a competitor bash, considering I just checked out the MQ site and the only product that has LPC in it IS LPC.
NO WAY. dballer is joking around again. LPC is Liquid Pussy Chromatograph. Have you ever seen The Highlander? You now the Quickenings when they decapitate another Highlander? Well, LPC works the same way. You point the gun at a woman and it shoots a light like the Quickening Lightning and the liquid cylinder has a broad Spectrum analysis of the pussy you pointed the LPC at and can tell you what the odds of her being a good relationship to persue are. Good Luck with it, they are expensive.
D
dballer
Guest
Kahn said:
That was not me.. look again!!!!!
