The metabolism of dromostanolone (2á-methyl-5á - androstan-17â-ol-3-one) was studied in three adult volunteers after oral dose of 20 mg. Solvent extracts of urine obtained after enzyme hydrolysis were derivatized with MSTFA/TMCS and MSTFA/TMIS. The structures of intact drug and its metabolites were determined by gas chromatography/mass spectrometry (GC/MS) in electron impact (EI) mode. The major metabolite (2á-methyl-5á- androstan-3á-ol-17-one), its 3â -epimer, parent compound, and several hydroxylated metabolites including intact drug were detected by comparing total ion chromatograms of control urine with that of the administered sample. Two epimers of 2á -methyl-5á- androstan-3,17â-diol were detected using selected ion monitoring. The maximum excretion of dromostanolone and 2á-methyl-5á- androstan-3á-ol-17-one was reached in 6.2-15 hr. The half-life of intact dromostanolone was 5.3 hr. About 3.0% of the administered amount was found to be excreted within 95 hr as unchanged form.
sorry about the accents over the alpha symbol,,i had to call upon the Korean Chemical Society for this one, they have some interesting stuff..literally