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Have you guys looked into this substance yet?
Very interesting, active substance ( called P57) is extracted from a cactus used in Africa to alleviate hunger.
I was informed there is a British company developing a product based on P57, and preliminary results from a phase 1 study in obese humans are encouraging.
Anyway, I would like to know if you have an oppinion about the substance.
BTW, congrats on your success with AF.
Rio.
Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside
David B. MacLean, and Lu-Guang Luo
Division of Endocrinology, Hallett Center for Diabetes and Endocrinology, Brown Medical School, Coro Building, Providence, RI 02903, USA
Accepted 1 April 2004. Available online 20 July 2004.
Abstract
A steroidal glycoside with anorectic activity in animals, termed P57AS3 (P57), was isolated from Hoodia gordonii and found to have homologies to the steroidal core of cardiac glycosides. Intracerebroventricular (i.c.v.) injections of the purified P57AS3 demonstrated that the compound has a likely central (CNS) mechanism of action. There is no evidence of P57AS3 binding to or altering activity of known receptors or proteins, including Na/K-ATPase, the putative target of cardiac glycosides. The studies demonstrated that the compound increases the content of ATP by 50–150% in hypothalamic neurons. In addition, third ventricle (i.c.v.) administration of P57, which reduces subsequent 24-h food intake by 40–60%, also increases ATP content in hypothalamic slice punches removed at 24 h following the i.c.v. injections. In related studies, in pair fed rats fed a low calorie diet for 4 days, the content of ATP in the hypothalami of control i.c.v. injected animals fell by 30–50%, which was blocked by i.c.v. injections of P57AS3. With growing evidence of metabolic or nutrient-sensing by the hypothalamus, ATP may be a common currency of energy sensing, which in turn may trigger the appropriate neural, endocrine and appetitive responses as similar to other fundamental hypothalamic homeostatic centers for temperature and osmolarity.
Author Keywords: Hypothalamus; Appetite regulation; ATP; Energy sensing; Plant steroidal glycoside
ypothalamus),
Very interesting, active substance ( called P57) is extracted from a cactus used in Africa to alleviate hunger.
I was informed there is a British company developing a product based on P57, and preliminary results from a phase 1 study in obese humans are encouraging.
Anyway, I would like to know if you have an oppinion about the substance.
BTW, congrats on your success with AF.
Rio.
Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside
David B. MacLean, and Lu-Guang Luo
Division of Endocrinology, Hallett Center for Diabetes and Endocrinology, Brown Medical School, Coro Building, Providence, RI 02903, USA
Accepted 1 April 2004. Available online 20 July 2004.
Abstract
A steroidal glycoside with anorectic activity in animals, termed P57AS3 (P57), was isolated from Hoodia gordonii and found to have homologies to the steroidal core of cardiac glycosides. Intracerebroventricular (i.c.v.) injections of the purified P57AS3 demonstrated that the compound has a likely central (CNS) mechanism of action. There is no evidence of P57AS3 binding to or altering activity of known receptors or proteins, including Na/K-ATPase, the putative target of cardiac glycosides. The studies demonstrated that the compound increases the content of ATP by 50–150% in hypothalamic neurons. In addition, third ventricle (i.c.v.) administration of P57, which reduces subsequent 24-h food intake by 40–60%, also increases ATP content in hypothalamic slice punches removed at 24 h following the i.c.v. injections. In related studies, in pair fed rats fed a low calorie diet for 4 days, the content of ATP in the hypothalami of control i.c.v. injected animals fell by 30–50%, which was blocked by i.c.v. injections of P57AS3. With growing evidence of metabolic or nutrient-sensing by the hypothalamus, ATP may be a common currency of energy sensing, which in turn may trigger the appropriate neural, endocrine and appetitive responses as similar to other fundamental hypothalamic homeostatic centers for temperature and osmolarity.
Author Keywords: Hypothalamus; Appetite regulation; ATP; Energy sensing; Plant steroidal glycoside
ypothalamus),
