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Liver???
- Thread starter barnes3
- Start date
YES, THE LIVER CAN REGENERATE, ALTHOUGH AT SOME POINT IT IS BEYOND REPAIR!
If you tae care of it, it will take care of you, but the reverse is also true.
Erring on the side of caution is always the best way, so use your head, and be careful> Do not stack heavy doses of multiple orals, take ALA, and Milk Thistle & drink lots of H20!
Ny the way some of the damage that can occur is in the form of liver tumors, which must be removed, because they can turn cancerous, something your body cannot fix!
If you tae care of it, it will take care of you, but the reverse is also true.
Erring on the side of caution is always the best way, so use your head, and be careful> Do not stack heavy doses of multiple orals, take ALA, and Milk Thistle & drink lots of H20!
Ny the way some of the damage that can occur is in the form of liver tumors, which must be removed, because they can turn cancerous, something your body cannot fix!
: J Biol Chem 1994 Aug 5;269(31):19667-70 Related Articles, Books, LinkOut
Liver expression of epidermal growth factor RNA. Rapid increases in immediate-early phase of liver regeneration.
Mullhaupt B, Feren A, Fodor E, Jones A.
Veterans Administration Medical Center, San Francisco, California.
The liver exhibits a remarkable capacity to regenerate its mass following partial removal or after injury. Transmembrane receptors for epidermal growth factor (EGF) are highly expressed in liver cells, which quickly respond to this polypeptide mitogen by activating an intrinsically low rate of cell division. Although EGF appears to regulate liver growth, its significance has remained unclear, and only a small change in serum levels can be detected during hepatocellular proliferation. Using a reverse transcription-polymerase chain reaction assay, we report here the novel finding that EGF RNA transcripts are synthesized in a hepatic cell-specific pattern, appearing in hepatocyte and lipocyte cell types. Our data reveal that within 15 min following a 70% liver removal, EGF RNA levels increase > 10-fold and then diminish below basal levels prior to the first wave of regenerative cell division. Immunoanalysis of metabolically labeled hepatocytes shows that EGF accumulates as a large 60-kDa peptide. These results demonstrate that EGF transcription is a previously unrecognized component of hepatic gene expression, and rapid increases in EGF RNA levels in the immediate-early phase of liver regeneration point to EGF as an autocrine factor in the prereplicative hepatic growth program.
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Pediatric Liver Transplant Program, Department of Pediatric Hepatology, University of California, San Francisco, 500 Parnassus Avenue, Box 0136, MU 4-East, San Francisco, CA 94143-0136, USA. [email protected].
Patients with fulminant hepatic failure fall into two categories: those who will not recover without hepatic replacement, and those with severe but potentially reversible liver injury whose livers have the potential to recover and/or regenerate. Liver support systems must provide physiologic support, rendering the patient hemodynamically stable and "bridging" the patient to transplantation, or allowing the native liver to recover and/or regenerate. Recent limited successes with bioartificial liver support for patients with fulminant liver failure are encouraging.
Liver expression of epidermal growth factor RNA. Rapid increases in immediate-early phase of liver regeneration.
Mullhaupt B, Feren A, Fodor E, Jones A.
Veterans Administration Medical Center, San Francisco, California.
The liver exhibits a remarkable capacity to regenerate its mass following partial removal or after injury. Transmembrane receptors for epidermal growth factor (EGF) are highly expressed in liver cells, which quickly respond to this polypeptide mitogen by activating an intrinsically low rate of cell division. Although EGF appears to regulate liver growth, its significance has remained unclear, and only a small change in serum levels can be detected during hepatocellular proliferation. Using a reverse transcription-polymerase chain reaction assay, we report here the novel finding that EGF RNA transcripts are synthesized in a hepatic cell-specific pattern, appearing in hepatocyte and lipocyte cell types. Our data reveal that within 15 min following a 70% liver removal, EGF RNA levels increase > 10-fold and then diminish below basal levels prior to the first wave of regenerative cell division. Immunoanalysis of metabolically labeled hepatocytes shows that EGF accumulates as a large 60-kDa peptide. These results demonstrate that EGF transcription is a previously unrecognized component of hepatic gene expression, and rapid increases in EGF RNA levels in the immediate-early phase of liver regeneration point to EGF as an autocrine factor in the prereplicative hepatic growth program.
-------------------------------------------------------------------------------------------------------------------
Pediatric Liver Transplant Program, Department of Pediatric Hepatology, University of California, San Francisco, 500 Parnassus Avenue, Box 0136, MU 4-East, San Francisco, CA 94143-0136, USA. [email protected].
Patients with fulminant hepatic failure fall into two categories: those who will not recover without hepatic replacement, and those with severe but potentially reversible liver injury whose livers have the potential to recover and/or regenerate. Liver support systems must provide physiologic support, rendering the patient hemodynamically stable and "bridging" the patient to transplantation, or allowing the native liver to recover and/or regenerate. Recent limited successes with bioartificial liver support for patients with fulminant liver failure are encouraging.
