While reading this and other forums I've come to understand that oral steroids may be toxic to the liver because of the 17-Alpha-Alkylated alteration to make them survive the pass through the liver. From what I understand both Anavar, Winstrol and Anadrol have this alteration, as does indeed a lot of over-the-counter drugs.
So what I would like to know is why some drugs, like Anadrol is concidered more toxic than, say Anavar? In theory taking 50mg of Anavar should be just as toxic as Anadrol.
If this is not so, than the steroid itself, Oxymetholone, must be toxic?!
I understand that the question is quite teoretical, but I would like to kow if someone actually can explain this, or if this is knowledge just passed from one user to another without ever being challenged.
Dude, there's alot of school of thought on this. Alot of speculation, alot of personal results, and alot of test results that were never targetted specifically at liver effects.
If you search the internet you'll find alot to read.
Personally, by my research and own experience I have come to believe the following:
All 17aa orals task the liver.
The Enzymes that most people watch that indicate liver issues are many times not inflated due to the liver at all, but can also be inflated by other tissues in the body, most notably muscle. High AST and ALT (the typical LFT values) readings can be effected by muscle tissue breakdown, something that any steroid can influence. So AST and ALT levels can be coming from multiple effects, not just the liver. I've had peroids of high LFTs before (currently still am) with no other liver function indicator (GGT and TBIL is perfect). I would imagine introducing 17aa orals into that environment can only raise those LFTs even more.
The effect seems to be more duration-related than dose related at normal dosing. Many tests I have read indicated that the liver values rose almost immediately, but stayed that level throughout the cycle. Only toward the end of long cycles did the more Liver-indicative values start to climb (like GGT and TBIL). Duration is the cause of Tylenol induced liver damage as well - taking tylenol every once in a while doesn't seem to be the problem, it's chronic use of the drug that leads to cirrhosis (sp?) of the liver. Again, because these statements were a "side bar" to the actual testing, there's no real literature concerning the true noted effects on the liver.
Many consider that Anavar is less toxic to the liver than other AAS, but this claim could be from the fact the Anavar is claimed to mostly bypass the liver. I've only read this claim by other posters, never in actual literature. I also believe it could be due to the fact that Anavar for so long was only available in small dosages and was very expensive, so it was used in small dosages - and why it may be duration-related, it probably to some extent is dose-related too, and 10mg of var will probably be less toxic than 60mg of dbol. I'll get to see how anavar effect me here in about 6 weeks
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Superdol got a really bad rap for being "extremely toxic". When I read all the threads of the complaints, overall it wasn't any more toxic than the threads I read on other orals - the problem was the Superdol was being used in main-stream supplement market where rasing liver values and killing your cholestrol was very rare to non-existent. Then pops in this true 17aa steroid - Sueprdol - that had all those negatives, and it was labelled as "extremely toxic". More toxic than Anavar or Tbol, maybe. But not really "extemely toxic" when kept in the company of other methylated AAS orals.
That being said, I've run two Tbol cycles, and both times my LFTs (AST and ALT) never reached even close to an alarming high, and right now (off AAS) those same values are high, and my rheumatologist says it's due to muscle values due to my heavy lifting.
All I can say is that I highly recommend anyone to always get blood work to chart your issues. Get a test during, right after ending, and 4 weeks out, to chart if you values are dropping or not.
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