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liver protection
- Thread starter bentz69
- Start date
r-ALA and Tyler's would be my choices.
macrophage69alpha
New member
edited options to reflect answers..
macrophage69alpha
New member
W6,
have not looked at that specific application though PAC's are great anti-oxidents
have not looked at that specific application though PAC's are great anti-oxidents
Check out the entire paper sometime. It is interesting material.
W6
Cellular Protection with Proanthocyanidins Derived from Grape Seeds
DEBASIS BAGCHIa,b, MANASHI BAGCHIa, SIDNEY J. STOHSa, SIDHARTHA D. RAYb, CHANDAN K. SENc and HARRY G. PREUSSd
a
Creighton University School of Pharmacy & Allied Health Professions, Omaha, Nebraska 68178, USA
bDepartment of Pharmacology, Toxicology and Medicinal Chemistry, AMS College of Pharmacy and Health Sciences, Long Island University, Brooklyn, New York 11201, USA
cLaboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
dDepartment of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20007, USA
Ann. N.Y. Acad. Sci. 957: 260-270 (2002).
Grape seed proanthocyanidins have been reported to possess a broad spectrum of pharmacological and medicinal properties against oxidative stress. We have demonstrated that IH636 proanthocyanidin extract (GSPE) provides excellent protection against free radicals in both in vitro and in vivo models. GSPE had significantly better free radical scavenging ability than vitamins C, E and ß-carotene and demonstrated significant cytotoxicity towards human breast, lung and gastric adenocarcinoma cells, while enhancing the growth and viability of normal cells. GSPE protected against tobacco-induced apoptotic cell death in human oral keratinocytes and provided protection against cancer chemotherapeutic drug-induced cytotoxicity in human liver cells by modulating cell cycle/apoptosis regulatory genes such as bcl2, p53 and c-myc. Recently, the bioavailability and mechanistic pathways of cytoprotection by GSPE were examined on acetaminophen-induced hepatotoxicity and nephrotoxicity, amiodarone-induced pulmonary toxicity, doxorubicin-induced cardiotoxicity, DMN-induced immunotoxicity and MOCAP-induced neurotoxicity in mice. Serum chemistry changes, integrity of genomic DNA and histopathology were assessed. GSPE pre-exposure provided near complete protection in terms of serum chemistry changes and DNA damage, as well as abolished apoptotic and necrotic cell death in all tissues. Histopathological examination reconfirmed these findings. GSPE demonstrated concentration-/dose-dependent inhibitory effects on the drug metabolizing enzyme cytochrome P450 2E1, and this may be a major pathway for the anti-toxic potential exerted by GSPE. Furthermore, GSPE treatment significantly decreased TNF-induced adherence of T-cells to HUVEC by inhibiting VCAM-1 expression. These results demonstrate that GSPE is highly bioavailable and may serve as a potential therapeutic tool in protecting multiple target organs from structurally diverse drug- and chemical-induced toxicity.
W6
Cellular Protection with Proanthocyanidins Derived from Grape Seeds
DEBASIS BAGCHIa,b, MANASHI BAGCHIa, SIDNEY J. STOHSa, SIDHARTHA D. RAYb, CHANDAN K. SENc and HARRY G. PREUSSd
a
Creighton University School of Pharmacy & Allied Health Professions, Omaha, Nebraska 68178, USA
bDepartment of Pharmacology, Toxicology and Medicinal Chemistry, AMS College of Pharmacy and Health Sciences, Long Island University, Brooklyn, New York 11201, USA
cLaboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
dDepartment of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20007, USA
Ann. N.Y. Acad. Sci. 957: 260-270 (2002).
Grape seed proanthocyanidins have been reported to possess a broad spectrum of pharmacological and medicinal properties against oxidative stress. We have demonstrated that IH636 proanthocyanidin extract (GSPE) provides excellent protection against free radicals in both in vitro and in vivo models. GSPE had significantly better free radical scavenging ability than vitamins C, E and ß-carotene and demonstrated significant cytotoxicity towards human breast, lung and gastric adenocarcinoma cells, while enhancing the growth and viability of normal cells. GSPE protected against tobacco-induced apoptotic cell death in human oral keratinocytes and provided protection against cancer chemotherapeutic drug-induced cytotoxicity in human liver cells by modulating cell cycle/apoptosis regulatory genes such as bcl2, p53 and c-myc. Recently, the bioavailability and mechanistic pathways of cytoprotection by GSPE were examined on acetaminophen-induced hepatotoxicity and nephrotoxicity, amiodarone-induced pulmonary toxicity, doxorubicin-induced cardiotoxicity, DMN-induced immunotoxicity and MOCAP-induced neurotoxicity in mice. Serum chemistry changes, integrity of genomic DNA and histopathology were assessed. GSPE pre-exposure provided near complete protection in terms of serum chemistry changes and DNA damage, as well as abolished apoptotic and necrotic cell death in all tissues. Histopathological examination reconfirmed these findings. GSPE demonstrated concentration-/dose-dependent inhibitory effects on the drug metabolizing enzyme cytochrome P450 2E1, and this may be a major pathway for the anti-toxic potential exerted by GSPE. Furthermore, GSPE treatment significantly decreased TNF-induced adherence of T-cells to HUVEC by inhibiting VCAM-1 expression. These results demonstrate that GSPE is highly bioavailable and may serve as a potential therapeutic tool in protecting multiple target organs from structurally diverse drug- and chemical-induced toxicity.
NorCalBdyBldr
New member
Has anyone know anything about Liv 52 for liver protection......does it work? Actually, I petrofied mine years ago and am on my third Baboon liver......LOL
NorCalBdyBldr said:
Poor baboons!
Anyway, back on topic: I have read a lot about liv.52 but have no experience with it.
I use ALA from a local vit store and Tylers from AS.
